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D-Index & Metrics

Genetics

D-Index
70
Citations
17336
World Ranking
2276
National Ranking
168

Research.com Recognitions

  • 2018 - Member of Academia Europaea

Overview

Zoltán Ivics is affiliated with the Paul Ehrlich Institut in Germany and has a research focus spanning several areas within biochemistry, genetics, molecular biology, and medicine. Their publication record includes significant contributions to molecular biology, genetics, immunology, and oncology. This broad scope is reflected across their work in gene editing technologies and cancer immunotherapy.

The scientist's recent publications cover topics such as genetic engineering, immune cell therapies, and genome editing mechanisms. Notable papers include:

  • "CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma" (2021, Gene Therapy)
  • "Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications of Sleeping Beauty, piggyBac and Tol2 for Genome Engineering" (2021, International Journal of Molecular Sciences)
  • "Choosing the Right Tool for Genetic Engineering: Clinical Lessons from Chimeric Antigen Receptor-T Cells" (2021, Human Gene Therapy)
  • "RNA-guided retargeting of Sleeping Beauty transposition in human cells" (2020, eLife)
  • "Time to evolve: predicting engineered T cell-associated toxicity with next-generation models" (2022, Journal for ImmunoTherapy of Cancer)

Research topics extensively covered by Ivics include:

  • CRISPR and Genetic Engineering
  • CAR-T cell therapy research
  • Virus-based gene therapy research
  • Chromosomal and Genetic Variations
  • RNA Interference and Gene Delivery
  • Advanced biosensing and bioanalysis techniques
  • Immune Cell Function and Interaction

The scientist collaborates frequently with several co-authors, with numerous joint publications alongside Csaba Miskey, Zsuzsanna Izsvák, Michael Hudecek, Daniel Tödt, and Richard J. P. Brown. These collaborations emphasize a strong network within the fields of gene therapy and genome engineering.

Ivics's work is regularly published in scientific journals such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • International Journal of Molecular Sciences
  • Nucleic Acids Research
  • Frontiers in Immunology
  • Gene Therapy

Main research fields include Biochemistry, Genetics and Molecular Biology with over a hundred publications, followed by Medicine. Major subfields of study reflect this focus with research distributed across Molecular Biology, Genetics, Immunology, Oncology, and Plant Science.

Recognition of Ivics's scientific contributions includes election as a Member of Academia Europaea in 2018.

Best Publications

  • Molecular Reconstruction of Sleeping Beauty, a Tc1-like Transposon from Fish, and Its Transposition in Human Cells

    Zoltán Ivics;Perry B Hackett;Ronald H Plasterk;Zsuzsanna Izsvák;Zsuzsanna Izsvák

  • Molecular evolution of a novel hyperactive Sleeping Beauty transposase enables robust stable gene transfer in vertebrates

    Lajos Mátés;Marinee K L Chuah;Eyayu Belay;Boris Jerchow

  • Somatic integration and long-term transgene expression in normal and haemophilic mice using a DNA transposon system.

    Stephen R. Yant;Leonard Meuse;Winnie Chiu;Zoltan Ivics

  • Resident aliens: the Tc1/mariner superfamily of transposable elements.

    Ronald H.A Plasterk;Zsuzsanna Izsvák;Zoltán Ivics

  • Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells

    Jichang Wang;Gangcai Xie;Manvendra Singh;Avazeh Tashakkori Ghanbarian

  • Sleeping Beauty, a wide host-range transposon vector for genetic transformation in vertebrates.

    Zsuzsanna Izsvák;Zoltán Ivics;Ronald H Plasterk

  • Transposon-mediated genome manipulation in vertebrates.

    Zoltán Ivics;Meng Amy Li;Lajos Mátés;Jef D Boeke

  • Chromosomal Transposition of a Tc1/Mariner-Like Element in Mouse Embryonic Stem Cells

    Guangbin Luo;Zoltán Ivics;Zsuzsanna Izsvák;Allan Bradley

  • Common physical properties of DNA affecting target site selection of sleeping beauty and other Tc1/mariner transposable elements.

    Thomas J. Vigdal;Christopher D. Kaufman;Zsuzsanna Izsvák;Zsuzsanna Izsvák;Daniel F. Voytas

  • Sleeping Beauty Transposition: Biology and Applications for Molecular Therapy

    Zsuzsanna Izsvák;Zsuzsanna Izsvák;Zoltán Ivics

  • Development of hyperactive sleeping beauty transposon vectors by mutational analysis.

    Hatem Zayed;Zsuzsanna Izsvák;Zsuzsanna Izsvák;Oliver Walisko;Zoltán Ivics

  • Molecular domestication of transposable elements: from detrimental parasites to useful host genes.

    L. Sinzelle;Z. Izsvák;Z. Izsvák;Z. Ivics

  • Comparative analysis of transposable element vector systems in human cells

    Ivana Grabundzija;Markus Irgang;Lajos Mátés;Eyayu Belay

  • Enhanced CAR T-cell engineering using non-viral Sleeping Beauty transposition from minicircle vectors

    R Monjezi;C Miskey;T Gogishvili;M Schleef

  • Identification of functional domains and evolution of Tc1-like transposable elements

    Zoltan Ivics;Zsuzsanna Izsvak;Zsuzsanna Izsvak;Adam Minter;Perry B. Hackett

  • The Frog Prince: a reconstructed transposon from Rana pipiens with high transpositional activity in vertebrate cells

    Csaba Miskey;Zsuzsanna Izsvák;Ronald H. Plasterk;Zoltán Ivics

  • The DNA‐bending protein HMGB1 is a cellular cofactor of Sleeping Beauty transposition

    Hatem Zayed;Zsuzsanna Izsvák;Zsuzsanna Izsvák;Dheeraj Khare;Udo Heinemann;Udo Heinemann

  • Involvement of a bifunctional, paired-like DNA-binding domain and a transpositional enhancer in Sleeping Beauty transposition.

    Zsuzsanna Izsvák;Dheeraj Khare;Joachim Behlke;Udo Heinemann

  • Targeted Sleeping Beauty transposition in human cells.

    Zoltán Ivics;Andrea Katzer;Eva E Stüwe;Dora Fiedler

  • The expanding universe of transposon technologies for gene and cell engineering.

    Zoltán Ivics;Zoltán Ivics;Zsuzsanna Izsvák;Zsuzsanna Izsvák

Frequent Co-Authors

Zsuzsanna Izsvák
Zsuzsanna Izsvák Max Delbrück Center for Molecular Medicine
Heiner Niemann
Heiner Niemann Friedrich-Loeffler-Institut
Thierry VandenDriessche
Thierry VandenDriessche Vrije Universiteit Brussel
Perry B. Hackett
Perry B. Hackett University of Minnesota
Peter Walter
Peter Walter University of California, San Francisco
Daniel Scherman
Daniel Scherman Université Paris Cité
Balázs Sarkadi
Balázs Sarkadi TTK Research Centre for Natural Sciences
Marinee Chuah
Marinee Chuah KU Leuven
Toni Cathomen
Toni Cathomen University of Freiburg
Ulrich Martin
Ulrich Martin Hannover Medical School

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