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Research.com Recognitions

  • 2026 - Research.com Medicine in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Medicine in United States Leader Award
  • 2023 - Research.com Medicine in United States Leader Award
  • 2013 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Pathology and Forensic Medicine

Overview

Ralph H. Hruban is affiliated with the Johns Hopkins University School of Medicine in the United States. Their research spans primarily within medicine and the intersecting discipline of biochemistry, genetics, and molecular biology. The main subfields of study covered comprise oncology, cancer research, surgery, molecular biology, and radiology, nuclear medicine, and imaging.

The scientist's work concentrates on several key topics including pancreatic and hepatic oncology research, cancer genomics and diagnostics, pancreatitis pathology and treatment, radiomics and machine learning in medical imaging, neuroendocrine tumor research advances, renal cell carcinoma treatment, and genetic factors in colorectal cancer.

Recent papers authored or coauthored by Ralph H. Hruban include:

  • "Circulating Tumor DNA Analysis Guiding Adjuvant Therapy in Stage II Colon Cancer," 2022, New England Journal of Medicine
  • "Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention," 2020, Science
  • "Proteogenomic characterization of pancreatic ductal adenocarcinoma," 2021, Cell
  • "Recent Trends in the Incidence and Survival of Stage 1A Pancreatic Cancer: A Surveillance, Epidemiology, and End Results Analysis," 2020, JNCI Journal of the National Cancer Institute
  • "The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival," 2022, Journal of Clinical Oncology

Frequent coauthors of their work include Elliot K. Fishman, Jin He, Laura D. Wood, Michael Goggins, and Christopher L. Wolfgang.

Ralph H. Hruban has a consistent publication record in several venues, notably bioRxiv (Cold Spring Harbor Laboratory), Gastroenterology, Cancer Research, Gastrointestinal Endoscopy, and Pancreatology.

The scientist has also contributed to academic book literature, including the publication titled Tumors of the Pancreas in 2023, associated with the American Registry of Pathology Arlington, Virginia eBooks, which has garnered some citations.

Among recognized honors, Ralph H. Hruban received an award from the German National Academy of Sciences Leopoldina in 2013, in the category of Pathology and Forensic Medicine.

Best Publications

  • PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

    Dung T. Le;Jennifer N. Uram;Hao Wang;Bjarne R. Bartlett

  • Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

    Siân Jones;Xiaosong Zhang;D. Williams Parsons;D. Williams Parsons;Jimmy Cheng Ho Lin

  • Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

    Chetan Bettegowda;Chetan Bettegowda;Mark Sausen;Rebecca J. Leary;Isaac Kinde

  • Genomic analyses identify molecular subtypes of pancreatic cancer

    Bailey P;Chang Dk;Nones K;Nones K;Johns Al

  • Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

    Kenneth P. Olive;Michael A. Jacobetz;Christian J. Davidson;Aarthi Gopinathan;Aarthi Gopinathan

  • DPC4, A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

    Stephan A. Hahn;Mieke Schutte;A. T. M. Shamsul Hoque;Christopher A. Moskaluk

  • Pan-cancer analysis of whole genomes

    Peter J. Campbell;Gad Getz;Jan O. Korbel;Joshua M. Stuart

  • Whole genomes redefine the mutational landscape of pancreatic cancer.

    Nicola Waddell;Marina Pajic;Ann Marie Patch;David K. Chang

  • Distant metastasis occurs late during the genetic evolution of pancreatic cancer

    Shinichi Yachida;Siân Jones;Ivana Bozic;Tibor Antal;Tibor Antal

  • Detection and localization of surgically resectable cancers with a multi-analyte blood test

    Joshua D. Cohen;Lu Li;Yuxuan Wang;Christopher Thoburn

  • Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

    Sunil R. Hingorani;Emanuel F. Petricoin;Anirban Maitra;Vinodh Rajapakse

  • Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice

    Sunil R. Hingorani;Lifu Wang;Asha S. Multani;Chelsea Combs

  • A draft map of the human proteome

    Min Sik Kim;Sneha M. Pinto;Derese Getnet;Raja Sekhar Nirujogi

  • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

    Gina M. DeNicola;Florian A. Karreth;Timothy J. Humpton;Aarthi Gopinathan

  • Six hundred fifty consecutive pancreaticoduodenectomies in the 1990s: pathology, complications, and outcomes.

    Charles J. Yeo;John L. Cameron;Taylor A. Sohn;Keith D. Lillemoe

  • Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

    Andrew V. Biankin;Andrew V. Biankin;Andrew V. Biankin;Nicola Waddell;Karin S. Kassahn;Marie Claude Gingras

  • Gene expression profiles in normal and cancer cells

    Bert Vogelstein;Kenneth W. Kinzler

  • Underlying causes and long-term survival in patients with initially unexplained cardiomyopathy.

    G M Felker;R E Thompson;J M Hare;R H Hruban

  • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

    Nishant Agrawal;Mitchell J. Frederick;Curtis R. Pickering;Chetan Bettegowda

  • Organoid Models of Human and Mouse Ductal Pancreatic Cancer

    Sylvia F. Boj;Chang Il Hwang;Chang Il Hwang;Lindsey A. Baker;Lindsey A. Baker;Iok In Christine Chio;Iok In Christine Chio

Frequent Co-Authors

Michael Goggins
Michael Goggins Johns Hopkins University
Charles J. Yeo
Charles J. Yeo Thomas Jefferson University
Christopher L. Wolfgang
Christopher L. Wolfgang New York University
Elliot K. Fishman
Elliot K. Fishman Johns Hopkins University
John L. Cameron
John L. Cameron Johns Hopkins University
Anirban Maitra
Anirban Maitra The University of Texas MD Anderson Cancer Center
Scott E. Kern
Scott E. Kern Johns Hopkins University
Richard D. Schulick
Richard D. Schulick University of Colorado Anschutz Medical Campus
Alison P. Klein
Alison P. Klein Johns Hopkins University
Bert Vogelstein
Bert Vogelstein Johns Hopkins University

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