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Medicine

D-Index
92
Citations
25233
World Ranking
11456
National Ranking
364

Overview

Wayne D. Tilley is affiliated with the University of Adelaide in Australia and has a research focus primarily in medicine, with significant contributions in biochemistry, genetics, and molecular biology. Their work frequently addresses cancer research, molecular biology, oncology, and genetics, reflecting a multidisciplinary approach to biomedical science.

Their publication record includes research on pulmonary and respiratory medicine, molecular biology, cancer research, oncology, and genetics. Key research topics include prostate cancer treatment and research, advanced breast cancer therapies, cancer, lipids, and metabolism, estrogen and related hormone effects, breast cancer treatment studies, cancer-related molecular pathways, and ubiquitin and proteasome pathways.

Notable recent research papers authored or coauthored by Wayne D. Tilley are:

  • Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction, 2021, Nature Genetics
  • The androgen receptor is a tumor suppressor in estrogen receptor-positive breast cancer, 2021, Nature Medicine
  • An androgen receptor switch underlies lineage infidelity in treatment-resistant prostate cancer, 2021, Nature Cell Biology
  • Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants, 2023, Nature Genetics
  • ELOVL5 Is a Critical and Targetable Fatty Acid Elongase in Prostate Cancer, 2021, Cancer Research

Frequent coauthors include:

  • Theresa E. Hickey
  • Luke A. Selth
  • Gail P. Risbridger
  • Renea A. Taylor
  • David E. Neal

The scientist has contributed extensively to multiple publication venues, including:

  • Cancer Research (11 publications)
  • The Prostate (8 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (5 publications)
  • Nature Genetics (3 publications)
  • British Journal of Cancer (3 publications)

Wayne D. Tilley's work covers complex biological mechanisms underlying cancer development and treatment resistance, focusing on hormonal pathways and genetic factors relevant to prostate and breast cancer. Their research integrates genome-wide association studies and molecular biology to identify risks and potential therapeutic targets. This breadth underscores their role in advancing understanding in cancer biology and therapy development.

Best Publications

  • Prostate cancer in a transgenic mouse.

    N M Greenberg;F DeMayo;M J Finegold;D Medina

  • Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

    Fredrick R. Schumacher;Ali Amin Al Olama;Sonja I. Berndt;Sara Benlloch

  • Progesterone receptor modulates ERα action in breast cancer

    Hisham Mohammed;I. Alasdair Russell;Rory Stark;Oscar M. Rueda

  • Characterization and expression of a cDNA encoding the human androgen receptor.

    Wayne D. Tilley;Marco Marcelli;Jean D. Wilson;Michael J. McPhaul

  • Mutations in the androgen receptor gene are associated with progression of human prostate cancer to androgen independence.

    Wayne D. Tilley;Grant Buchanan;Theresa E. Hickey;Jacqueline M. Bentel

  • Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer.

    Amelia A. Peters;Grant Buchanan;Carmela Ricciardelli;Tina Bianco-Miotto

  • Dual Roles of PARP-1 Promote Cancer Growth and Progression

    Matthew J. Schiewer;Jonathan F. Goodwin;Sumin Han;J. Chad Brenner

  • Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction

    David V. Conti;Burcu F. Darst;Lilit C. Moss;Edward J. Saunders

  • Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1

    Jessica L L Robinson;Stewart MacArthur;Caryn S Ross‐Innes;Wayne D Tilley

  • Androgens induce divergent proliferative responses in human breast cancer cell lines

    S.N. Birrell;J.M. Bentel;T.E. Hickey;C. Ricciardelli

  • Minireview: The Androgen Receptor in Breast Tissues: Growth Inhibitor, Tumor Suppressor, Oncogene?

    T. E. Hickey;J. L. L. Robinson;J. S. Carroll;W. D. Tilley

  • Breast and prostate cancer: more similar than different.

    Gail Petuna Risbridger;Ian D Davis;Stephen N Birrell;Wayne D Tilley

  • Targeting the androgen receptor: improving outcomes for castration-resistant prostate cancer

    Howard I Scher;Grant Buchanan;William Gerald;Lisa M Butler

  • Androgen receptor coregulators and their involvement in the development and progression of prostate cancer

    Ren ee Chmelar;Grant Buchanan;Eleanor F. Need;Wayne Tilley

  • Vascular Endothelial Growth Factor (VEGF) Expression in Prostate Cancer and Benign Prostatic Hyperplasia

    Michael W. Jackson;Jacqueline M. Bentel;Wayne D. Tilley

  • Androgen receptor gene expression in human prostate carcinoma cell lines.

    W. D. Tilley;C. M. Wilson;M. Marcelli;M. J. McPhaul

  • A Potential Autocrine Role for Vascular Endothelial Growth Factor in Prostate Cancer

    Michael W. Jackson;James S. Roberts;Susan E. Heckford;Carmela Ricciardelli

  • Collocation of androgen receptor gene mutations in prostate cancer.

    Grant Buchanan;Norman M. Greenberg;Howard I. Scher;Jonathan M. Harris

  • Structural and functional consequences of glutamine tract variation in the androgen receptor

    Grant Buchanan;Miao Yang;Albert Cheong;Jonathan M. Harris

  • Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors.

    Jeffry L. Dean;A. Kathleen McClendon;Theresa E. Hickey;Lisa M. Butler

Frequent Co-Authors

Lisa M. Butler
Lisa M. Butler University of Adelaide
Graham G. Giles
Graham G. Giles University of Melbourne
David E. Neal
David E. Neal University of Cambridge
Jason S. Carroll
Jason S. Carroll University of Cambridge
Judith A. Clements
Judith A. Clements Queensland University of Technology
Gerhard A. Coetzee
Gerhard A. Coetzee University of Southern California
Howard I. Scher
Howard I. Scher Memorial Sloan Kettering Cancer Center
Gregory J. Goodall
Gregory J. Goodall University of Adelaide
James G. Kench
James G. Kench Royal Prince Alfred Hospital
Lisa A. Cannon-Albright
Lisa A. Cannon-Albright University of Utah

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