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2025

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Overview

David Sidransky is a researcher affiliated with Johns Hopkins University School of Medicine in the United States. Their work focuses primarily on medicine and biochemistry, genetics, and molecular biology, with significant contributions in molecular biology, oncology, cancer research, infectious diseases, and pulmonary and respiratory medicine.

The scientist's research covers several main topics, including:

  • RNA modifications and cancer
  • Head and Neck Cancer Studies
  • Lung Cancer Treatments and Mutations
  • Cancer-related Molecular Pathways
  • Cancer-related molecular mechanisms research
  • Cervical Cancer and HPV Research
  • Oral Health Pathology and Treatment

Recent publications highlight their involvement in cancer and molecular biology studies. Notable papers include:

  • Genome-wide profiling of non-smoking-related lung cancer cells reveals common RB1 rearrangements associated with histopathologic transformation in EGFR-mutant tumors, 2020, Annals of Oncology
  • Chromatin structure regulates cancer-specific alternative splicing events in primary HPV-related oropharyngeal squamous cell carcinoma, 2020, Epigenetics
  • Molecular Profiling Associated with Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2)-Mediated Carcinogenesis in Gastric Cancer, 2021, Journal of Proteome Research
  • Whole-Exome Sequencing Analysis of Oral Squamous Cell Carcinoma Delineated by Tobacco Usage Habits, 2021, Frontiers in Oncology
  • Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma, 2021, Frontiers in Oncology

The scientist frequently collaborates with other researchers, with frequent co-authors including:

  • Aditi Chatterjee
  • Mariana Brait
  • Fernando T. Zamunér
  • Harsha Gowda
  • Rafael Guerrero-Preston

David Sidransky's research has appeared most frequently in the following publication venues:

  • Cancer Research
  • Frontiers in Oncology
  • Cancers
  • Cancer Prevention Research
  • OMICS A Journal of Integrative Biology

Best Publications

  • p53 mutations in human cancers

    Monica Hollstein;David Sidransky;Bert Vogelstein;Curtis C. Harris

  • Participation of p53 Protein in the Cellular Response to DNA Damage

    Michael B. Kastan;Onyinye Onyekwere;David Sidransky;Bert Vogelstein

  • A National Cancer Institute Workshop on Microsatellite Instability for Cancer Detection and Familial Predisposition: Development of International Criteria for the Determination of Microsatellite Instability in Colorectal Cancer

    C. Richard Boland;Stephen N. Thibodeau;Stanley R. Hamilton;David Sidransky

  • Evidence for a Causal Association Between Human Papillomavirus and a Subset of Head and Neck Cancers

    Maura Gillison;Wayne M. Koch;Randolph B. Capone;Michael Spafford

  • 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers.

    Adrian Merlo;James G. Herman;Li Mao;Daniel J. Lee

  • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

    Nishant Agrawal;Mitchell J. Frederick;Curtis R. Pickering;Chetan Bettegowda

  • Inactivation of the CDKN2/p16/MTS1 Gene Is Frequently Associated with Aberrant DNA Methylation in All Common Human Cancers

    James G. Herman;Adrian Merlo;Li Mao;Rena G. Lapidus

  • Genetic progression model for head and neck cancer: Implications for field cancerization

    Joseph Califano;Peter Van Der Riet;William Westra;Homaira Nawroz

  • Head and neck cancer.

    Arlene Forastiere;Wayne Koch;Andrew Trotti;David Sidransky

  • Detection of Aberrant Promoter Hypermethylation of Tumor Suppressor Genes in Serum DNA from Non-Small Cell Lung Cancer Patients

    Manel Esteller;Montserrat Sanchez-Cespedes;Rafael Rosell;David Sidransky

  • BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer

    Mingzhao Xing;William H. Westra;Ralph P. Tufano;Yoram Cohen

  • Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer.

    Anju Singh;Vikas Misra;Rajesh K Thimmulappa;Hannah Lee

  • BRAF Mutation in Papillary Thyroid Carcinoma

    Yoram Cohen;Mingzhao Xing;Elizabeth Mambo;Zhongmin Guo

  • Identification of p53 gene mutations in bladder cancers and urine samples

    David Sidransky;Andrew Von Eschenbach;Yvonne C. Tsai;Peter Jones

  • Facile Detection of Mitochondrial DNA Mutations in Tumors and Bodily Fluids

    Makiko S. Fliss;Henning Usadel;Otávia L. Caballero;Li Wu

  • Mutations in BRAF and KRAS Characterize the Development of Low-Grade Ovarian Serous Carcinoma

    Gad Singer;Robert Oldt;Yoram Cohen;Brant G. Wang

  • Association between BRAF V600E mutation and mortality in patients with papillary thyroid cancer

    Michael Mingzhao Xing;Ali S. Alzahrani;Kathryn A. Carson;David Viola

  • Frequent Inactivation of PTEN/MMAC1 in Primary Prostate Cancer

    P Cairns;K Okami;S Halachmi;N Halachmi

  • Identification of ras oncogene mutations in the stool of patients with curable colorectal tumors.

    David Sidransky;Takashi Tokino;Stanley R. Hamilton;Kenneth W. Kinzler

  • Emerging molecular markers of cancer

    David Sidransky

Frequent Co-Authors

Joseph A. Califano
Joseph A. Califano University of California, San Diego
William H. Westra
William H. Westra Icahn School of Medicine at Mount Sinai
Wayne M. Koch
Wayne M. Koch Johns Hopkins University
Jin Jen
Jin Jen Bristol Myers Squibb
Carmen Jerónimo
Carmen Jerónimo University of Porto
T. S. Keshava Prasad
T. S. Keshava Prasad Yenepoya University
Rui Henrique
Rui Henrique University of Porto
George J. Netto
George J. Netto University of Alabama at Birmingham
Marianna Zahurak
Marianna Zahurak Johns Hopkins University
Li Mao
Li Mao University of Maryland, Baltimore

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