World's Best Scientists 2026 revealed!

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Medicine

D-Index
102
Citations
43648
World Ranking
7588
National Ranking
3956

Overview

Joseph A. Califano is affiliated with the University of California, San Diego in the United States. Their research spans interdisciplinary fields primarily within Medicine and Biochemistry, Genetics and Molecular Biology. The scientist's work engages deeply with subfields such as Oncology, Molecular Biology, Otorhinolaryngology, Surgery, and Immunology.

The primary themes of Califano's research focus on multiple important areas including:

  • Head and Neck Cancer Studies
  • Cancer Immunotherapy and Biomarkers
  • Immunotherapy and Immune Responses
  • Head and Neck Surgical Oncology
  • RNA modifications and cancer
  • Cervical Cancer and HPV Research
  • Epigenetics and DNA Methylation

The scientist has published in numerous venues, most frequently contributing to:

  • International Journal of Radiation Oncology*Biology*Physics
  • Head & Neck
  • Journal of Clinical Oncology
  • Clinical Cancer Research
  • Regular and Young Investigator Award Abstracts

Among notable recent papers by Joseph A. Califano are:

  • "B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade" (2020, Clinical Cancer Research)
  • "Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC" (2022, Nature Communications)
  • "HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers" (2020, Oncogene)
  • "Disruption of the HER3-PI3K-mTOR oncogenic signaling axis and PD-1 blockade as a multimodal precision immunotherapy in head and neck cancer" (2021, Nature Communications)
  • "Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation" (2020, Clinical Cancer Research)

The scientist collaborates frequently with a range of coauthors including Andrew B. Sharabi, J. Silvio Gutkind, Farhoud Faraji, Robert Saddawi-Konefka, and Ezra E.W. Cohen. Collaboration counts indicate substantial joint research efforts, with counts ranging from 17 to 30.

Best Publications

  • Comprehensive genomic characterization of head and neck squamous cell carcinomas

    Michael S. Lawrence;Carrie Sougnez;Lee Lichtenstein;Kristian Cibulskis

  • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1

    Nishant Agrawal;Mitchell J. Frederick;Curtis R. Pickering;Chetan Bettegowda

  • Genetic progression model for head and neck cancer: Implications for field cancerization

    Joseph Califano;Peter Van Der Riet;William Westra;Homaira Nawroz

  • BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer

    Mingzhao Xing;William H. Westra;Ralph P. Tufano;Yoram Cohen

  • Trends in incidence and prognosis for head and neck cancer in the United States: A site-specific analysis of the SEER database

    André Lopes Carvalho;Inês Nobuko Nishimoto;Joseph A. Califano;Luiz Paulo Kowalski

  • Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

    Paolo Serafini;Kristen Meckel;Michael Kelso;Kimberly Noonan

  • TP53 mutations and survival in squamous-cell carcinoma of the head and neck.

    M. Luana Poeta;M. Luana Poeta;Judith Manola;Meredith A. Goldwasser;Arlene Forastiere

  • Correction: Corrigendum: A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma

    Aneesha Radhakrishnan;Vishalakshi Nanjappa;Remya Raja;Gajanan Sathe

  • High Frequency of p16 (CDKN2/MTS-1/INK4A) Inactivation in Head and Neck Squamous Cell Carcinoma

    Andre L. Reed;Joseph Califano;Paul Cairns;William H. Westra

  • Frequency of homozygous deletion at p16/CDKN2 in primary human tumours

    P. Cairns;T. J. Polascik;Y. Eby;K. Tokino

  • Consensus Statement on the Classification and Terminology of Neck Dissection

    K. Thomas Robbins;Ashok R. Shaha;Jesus E. Medina;Joseph A. Califano

  • Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas.

    Yuxuan Wang;Simeon Springer;Carolyn L. Mulvey;Natalie Silliman

  • Promoter Hypermethylation Patterns of p16, O6-Methylguanine-DNA-methyltransferase, and Death-associated Protein Kinase in Tumors and Saliva of Head and Neck Cancer Patients

    Siane Lopes Bittencourt Rosas;Siane Lopes Bittencourt Rosas;Wayne Koch;Maria da Gloria da Costa Carvalho;Li Wu

  • CYSTIC LYMPH NODE METASTASIS IN PATIENTS WITH HEAD AND NECK CANCER: AN HPV-ASSOCIATED PHENOMENON

    David Goldenberg;Shahnaz Begum;William H. Westra;Zubair Khan

  • Characterization of HPV and host genome interactions in primary head and neck cancers.

    Michael Parfenov;Chandra Sekhar Pedamallu;Nils Gehlenborg;Nils Gehlenborg;Samuel S. Freeman

  • Pyruvate Dehydrogenase Complex Activity Controls Metabolic and Malignant Phenotype in Cancer Cells

    Thomas McFate;Ahmed Mohyeldin;Huasheng Lu;Jay Thakar

  • Global oral health inequalities in incidence and outcomes for oral cancer: causes and solutions.

    Newell Walter Johnson;S. Warnakulasuriya;P.C. Gupta;E. Dimba

  • ΔNp63α and TAp63α regulate transcription of genes with distinct biological functions in cancer and development

    Guojun Wu;Shuji Nomoto;Mohammad Obaidul Hoque;Tatiana Dracheva

  • MicroRNA alterations in Head and Neck Squamous Cell Carcinoma

    Steven S. Chang;Wei Wen Jiang;Ian Smith;Luana M. Poeta

  • A genetic progression model for head and neck cancer: Implications for field cancerization

    Joseph A. Califano;Gary Clayman;David Sidransky;Wayne Koch

Frequent Co-Authors

David Sidransky
David Sidransky Johns Hopkins University School of Medicine
William H. Westra
William H. Westra Icahn School of Medicine at Mount Sinai
Wayne M. Koch
Wayne M. Koch Johns Hopkins University
Ludmila Danilova
Ludmila Danilova Johns Hopkins University
Ezra E.W. Cohen
Ezra E.W. Cohen University of California, San Diego
J. Silvio Gutkind
J. Silvio Gutkind University of California, San Diego
David M. Goldenberg
David M. Goldenberg Immunomedics (United States)
Marianna Zahurak
Marianna Zahurak Johns Hopkins University
T. S. Keshava Prasad
T. S. Keshava Prasad Yenepoya University
Carmen Jerónimo
Carmen Jerónimo University of Porto

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