World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
139
Citations
71432
World Ranking
283
National Ranking
191

Medicine

D-Index
138
Citations
70616
World Ranking
1832
National Ranking
1046

Overview

J. Silvio Gutkind is affiliated with the University of California, San Diego, in the United States. Their research spans multiple fields within the life sciences, with a strong emphasis on biochemistry, genetics, and molecular biology, as well as medicine.

The scientist has a substantial publication record across various specialized topics including:

  • Cancer Immunotherapy and Biomarkers
  • Hippo pathway signaling and YAP/TAZ
  • Immunotherapy and Immune Responses
  • Receptor Mechanisms and Signaling
  • Ubiquitin and proteasome pathways
  • PI3K/AKT/mTOR signaling in cancer
  • Cancer-related gene regulation

Their research contributions have been published in several prominent venues. The most frequent publication outlets include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Clinical Cancer Research
  • Nature Communications
  • International Journal of Radiation Oncology*Biology*Physics

Among their recent papers are:

  • "B Cells Improve Overall Survival in HPV-Associated Squamous Cell Carcinomas and Are Activated by Radiation and PD-1 Blockade" (2020), Clinical Cancer Research
  • "Lymphatic-preserving treatment sequencing with immune checkpoint inhibition unleashes cDC1-dependent antitumor immunity in HNSCC" (2022), Nature Communications
  • "G Protein-Coupled receptors and heterotrimeric G proteins as cancer drivers" (2020), FEBS Letters
  • "Transcriptional repression of estrogen receptor alpha by YAP reveals the Hippo pathway as therapeutic target for ER+ breast cancer" (2022), Nature Communications
  • "Tipifarnib as a Precision Therapy for HRAS -Mutant Head and Neck Squamous Cell Carcinomas" (2020), Molecular Cancer Therapeutics

Collaborations are a notable part of their work, with frequent coauthors including:

  • Zhiyong Wang
  • Robert Saddawi-Konefka
  • Joseph A. Califano
  • Alfredo Molinolo
  • Ezra E.W. Cohen

Gutkind's subfields of study highlight a multidisciplinary approach, with significant involvement in:

  • Molecular Biology
  • Oncology
  • Cell Biology
  • Immunology
  • Pulmonary and Respiratory Medicine

Best Publications

  • The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

    Omar A. Coso;Mario Chiariello;Jin-Chen Yu;Hidemi Teramoto

  • Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate.

    Olivier Cuvillier;Grisha Pirianov;Burkhard Kleuser;Philip G. Vanek

  • G-protein-coupled receptors and cancer.

    Robert T. Dorsam;J. Silvio Gutkind

  • Integrin function: molecular hierarchies of cytoskeletal and signaling molecules.

    S Miyamoto;H Teramoto;O A Coso;J S Gutkind

  • G-protein-coupled receptors and signaling networks: emerging paradigms.

    Maria Julia Marinissen;J.Silvio Gutkind

  • VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin.

    Julie Gavard;J. Silvio Gutkind

  • Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

    Maria Domenica Castellone;Hidemi Teramoto;Bart O. Williams;Kirk M. Druey

  • Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

    P. Crespo;Ningzhi Xu;W. F. Simonds;J. S. Gutkind

  • G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator

    Carlos Bais;Bianca Santomasso;Omar Coso;Leandros Arvanitakis;Leandros Arvanitakis

  • Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery.

    Ashwin A. Bhirde;Vyomesh Patel;Julie Gavard;Guofeng Zhang

  • Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors.

    S Miyamoto;H Teramoto;J S Gutkind;K M Yamada

  • Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

    Piero Crespo;Piero Crespo;Kornel E. Schuebel;Amy A. Ostrom;J. Silvio Gutkind

  • Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

    Marco Lopez-Ilasaca;Piero Crespo;P. Giuseppe Pellici;J. Silvio Gutkind

  • Augmented Wnt Signaling in a Mammalian Model of Accelerated Aging

    Hongjun Liu;Maria M Fergusson;Rogerio M. Castilho;Jie Liu

  • Carbon nanotube amplification strategies for highly sensitive immunodetection of cancer biomarkers.

    Xin Yu;Bernard Munge;Vyomesh Patel;Gary Jensen

  • G12-G13-LARG-mediated signaling in vascular smooth muscle is required for salt-induced hypertension.

    Angela Wirth;Zoltán Benyó;Zoltán Benyó;Martina Lukasova;Barbara Leutgeb;Barbara Leutgeb

  • Cbl-b regulates the CD28 dependence of T-cell activation

    Yungping J. Chiang;Hemanta K. Kole;Karen Brown;Mayumi Naramura

  • Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer

    James F. Rusling;James F. Rusling;James F. Rusling;Challa V. Kumar;J. Silvio Gutkind;Vyomesh Patel

  • The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer

    Morgan O'Hayre;José Vázquez-Prado;Irina Kufareva;Eric W. Stawiski

  • Ultrasensitive Immunosensor for Cancer Biomarker Proteins using Gold Nanoparticle Film Electrodes and Multienzyme-Particle Amplification

    Vigneshwaran Mani;Bhaskara V. Chikkaveeraiah;Vyomesh Patel;J. Silvio Gutkind

Frequent Co-Authors

Alfredo A. Molinolo
Alfredo A. Molinolo University of California, San Diego
James F. Rusling
James F. Rusling University of Connecticut
Joseph A. Califano
Joseph A. Califano University of California, San Diego
Qianming Chen
Qianming Chen Sichuan University
Julie Gavard
Julie Gavard University of Nantes
Asuka Inoue
Asuka Inoue Tohoku University
Shigetomo Fukuhara
Shigetomo Fukuhara Nippon Medical School
Thomas H. Bugge
Thomas H. Bugge National Institutes of Health
Scott M. Lippman
Scott M. Lippman University of California, San Diego
Piero Crespo
Piero Crespo Spanish National Research Council

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