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Biology and Biochemistry

D-Index
44
Citations
10994
World Ranking
19217
National Ranking
439

Overview

Piero Crespo is affiliated with the Spanish National Research Council in Spain. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with notable contributions also in medicine. Crespo's work delves into molecular biology at a detailed level, often intersecting with oncology and pathology.

The scientist's main research subfields are:

  • Molecular Biology
  • Oncology
  • Pathology and Forensic Medicine
  • Endocrinology, Diabetes and Metabolism
  • Neurology

Crespo has focused on several key topics throughout their publications, including:

  • Melanoma and MAPK Pathways
  • Protein Kinase Regulation and GTPase Signaling
  • Genomics and Chromatin Dynamics
  • Chromatin Remodeling and Cancer
  • Cancer Mechanisms and Therapy
  • Cell Death Mechanisms and Regulation
  • Thyroid Cancer Diagnosis and Treatment

Frequent publication venues featuring Crespo's research include:

  • Oncogene
  • Molecular Oncology
  • Scientific Reports
  • Science Signaling
  • Science Advances

Several recent scientific papers authored by Crespo address important mechanisms and pathways related to cancer biology and treatment resistance. These include:

  • ARID2 deficiency promotes tumor progression and is associated with higher sensitivity to chemotherapy in lung cancer, 2021, Oncogene
  • Metallothionein-3 promotes cisplatin chemoresistance remodelling in neuroblastoma, 2021, Scientific Reports
  • RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness, 2020, Molecular Biology of the Cell
  • ERK2 stimulates MYC transcription by anchoring CDK9 to the MYC promoter in a kinase activity-independent manner, 2023, Science Signaling
  • Immune Checkpoint Inhibitors and RAS-ERK Pathway-Targeted Drugs as Combined Therapy for the Treatment of Melanoma, 2022, Biomolecules

Crespo frequently collaborates with several co-authors, who have contributed repeatedly to their work. These co-authors are:

  • Berta Casar
  • Marta Morante
  • Rocío García-Gómez
  • Xosé R. Bustelo
  • Ana Herrero

The profile of research ranged from signaling pathways that involve protein kinases and GTPases to mechanistic understandings of chromatin remodeling in cancer, reflecting a multidisciplinary approach. Key scientific contributions focus on cancer progression, treatment resistance, and cellular signaling mechanisms underlying melanoma and other cancers.

Best Publications

  • The small GTP-binding proteins Rac1 and Cdc42regulate the activity of the JNK/SAPK signaling pathway

    Omar A. Coso;Mario Chiariello;Jin-Chen Yu;Hidemi Teramoto

  • Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

    P. Crespo;Ningzhi Xu;W. F. Simonds;J. S. Gutkind

  • Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product

    Piero Crespo;Piero Crespo;Kornel E. Schuebel;Amy A. Ostrom;J. Silvio Gutkind

  • Linkage of G Protein-Coupled Receptors to the MAPK Signaling Pathway Through PI 3-Kinase γ

    Marco Lopez-Ilasaca;Piero Crespo;P. Giuseppe Pellici;J. Silvio Gutkind

  • Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition.

    P Crespo;T G Cachero;N Xu;J S Gutkind

  • Ras proteins in the control of the cell cycle and cell differentiation.

    P Crespo;J León

  • The small GTP-binding protein rho activates c-Jun N-terminal kinases/stress-activated protein kinases in human kidney 293T cells. Evidence for a Pak-independent signaling pathway.

    Hidemi Teramoto;Piero Crespo;Omar A. Coso;Tadashi Igishi

  • Erk5 Participates in Neuregulin Signal Transduction and Is Constitutively Active in Breast Cancer Cells Overexpressing ErbB2

    Azucena Esparís-Ogando;Elena Díaz-Rodríguez;Juan Carlos Montero;Laura Yuste

  • Rac-1 dependent stimulation of the JNK/SAPK signaling pathway by Vav.

    Crespo P;Bustelo Xr;Aaronson Ds;Coso Oa

  • Fast regulation of AP-1 activity through interaction of lamin A/C, ERK1/2, and c-Fos at the nuclear envelope

    José María González;Ana Navarro-Puche;Berta Casar;Piero Crespo

  • Essential Role of ERK Dimers in the Activation of Cytoplasmic but Not Nuclear Substrates by ERK-Scaffold Complexes

    Berta Casar;Adán Pinto;Piero Crespo

  • Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.

    David Matallanas;Victoria Sanz-Moreno;Imanol Arozarena;Fernando Calvo

  • Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK

    Sandra Peregrin;Maria Jurado-Pueyo;Pedro M. Campos;Victoria Sanz-Moreno

  • Differences on the Inhibitory Specificities of H-Ras, K-Ras, and N-Ras (N17) Dominant Negative Mutants Are Related to Their Membrane Microlocalization

    David Matallanas;Imanol Arozarena;Marı́a T. Berciano;David S. Aaronson

  • Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes.

    Ana Herrero;Adán Pinto;Paula Colón-Bolea;Berta Casar

  • Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras

    David Matallanas;David Romano;Fahd Al-Mulla;Eric O'Neill

  • Mechanisms of action of vitamin D in colon cancer

    Gemma Ferrer-Mayorga;María Jesús Larriba;Piero Crespo;Alberto Muñoz

  • Ras subcellular localization defines extracellular signal-regulated kinase 1 and 2 substrate specificity through distinct utilization of scaffold proteins.

    Berta Casar;Imanol Arozarena;Victoria Sanz-Moreno;Adán Pinto

  • Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.

    Imanol Arozarena;David Matallanas;María T. Berciano;Victoria Sanz-Moreno

  • Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.

    P. Crespo;Ningzhi Xu;J. L. Daniotti;J. Troppmair

Frequent Co-Authors

Xosé R. Bustelo
Xosé R. Bustelo University of Salamanca
J. Silvio Gutkind
J. Silvio Gutkind University of California, San Diego
Pilar Santisteban
Pilar Santisteban Spanish National Research Council
Eugenio Santos
Eugenio Santos University of Salamanca
Mariano Barbacid
Mariano Barbacid Spanish National Cancer Research Centre
Walter Kolch
Walter Kolch University College Dublin
Jose M. Ordovas
Jose M. Ordovas Tufts University
Eduardo Salido
Eduardo Salido Hospital Universitario de Canarias
Angel Pazos
Angel Pazos University of Cantabria
Juan Bernal
Juan Bernal Autonomous University of Madrid

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