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Biology and Biochemistry

D-Index
53
Citations
13131
World Ranking
16002
National Ranking
352

Overview

Eugenio Santos is a researcher affiliated with the University of Salamanca in Spain. Their scientific work spans several fields, primarily focusing on biochemistry, genetics, and molecular biology. Medicine is another significant field in their research portfolio.

The subfields covered in their publications include molecular biology, cell biology, cancer research, radiology, nuclear medicine and imaging, and oncology. This diverse range indicates a multidisciplinary approach within the biosciences and clinical research domains.

The main topics of Eugenio Santos's research feature:

  • Protein kinase regulation and GTPase signaling
  • Protein tyrosine phosphatases
  • Ubiquitin and proteasome pathways
  • Monoclonal and polyclonal antibodies research
  • ATP synthase and ATPases research
  • Neonatal respiratory health research
  • Cancer, hypoxia, and metabolism

Frequent collaboration has been established with several coauthors, reflecting overlapping research interests and joint studies. These coauthors include:

  • Rósula García-Navas
  • Fernando C. Baltanás
  • Nuria Calzada
  • Alberto Fernández-Medarde
  • Rocío Fuentes-Mateos

Eugenio Santos has published regularly in a number of scientific journals. The most frequent publication venues are:

  • Oncogene
  • International Journal of Molecular Sciences
  • Cancers
  • Cell Communication and Signaling
  • bioRxiv (Cold Spring Harbor Laboratory)

Selected recent papers exemplify Eugenio Santos's research themes and dissemination outlets:

  • "SOS GEFs in health and disease", 2020, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
  • "40 Years of RAS-A Historic Overview", 2021, Genes
  • "Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis", 2021, Oncogene
  • "SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology", 2021, International Journal of Molecular Sciences
  • "The Childhood-Onset Neurodegeneration with Cerebellar Atrophy (CONDCA) Disease Caused by AGTPBP1 Gene Mutations: The Purkinje Cell Degeneration Mouse as an Animal Model for the Study of this Human Disease", 2021, Biomedicines

Best Publications

  • A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

    E. Premkumar Reddy;Roberta K. Reynolds;Eugenio Santos;Mariano Barbacid

  • Ras in cancer and developmental diseases.

    Alberto Fernández-Medarde;Eugenio Santos

  • T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes

    Eugenio Santos;Steven R. Tronick;Stuart A. Aaronson;Simonetta Pulciani

  • Oncogenes in solid human tumours

    Simonetta Pulciani;Eugenio Santos;Anne V. Lauver;Linda K. Long

  • Malignant activation of a K-ras oncogene in lung carcinoma but not in normal tissue of the same patient

    E Santos;D Martin-Zanca;EP Reddy;MA Pierotti

  • Targeted genomic disruption of H-ras and N-ras, individually or in combination, reveals the dispensability of both loci for mouse growth and development.

    Luis M. Esteban;Carlos Vicario-Abejón;Pedro Fernández-Salguero;Alberto Fernández-Medarde

  • Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells.

    Simonetta Pulciani;Eugenio Santos;Anne V. Lauver;Linda K. Long

  • Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

    Matthias Drosten;Alma Dhawahir;Eleanor Y M Sum;Jelena Urosevic

  • Functional specificity of ras isoforms: so similar but so different.

    Esther Castellano;Eugenio Santos

  • Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

    Gunter Schumann;Lachlan J. Coin;Anbarasu Lourdusamy;Pimphen Charoen;Pimphen Charoen

  • Structural and functional properties of ras proteins.

    Eugenio Santos;Angel R. Nebreda

  • A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25

    Pirro G Hysi;Terri L Young;David A Mackey;David A Mackey;Toby Andrew

  • ras gene Amplification and malignant transformation.

    S. Pulciani;E. Santos;L. K. Long;Vincenzo Sorrentino

  • Mitogen-activated protein kinase activation is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation.

    J Font de Mora;A Porras;N Ahn;E Santos

  • Differentiation of 3T3-L1 fibroblasts to adipocytes induced by transfection of ras oncogenes.

    Manuel Benito;Almudena Porras;Angel R. Nebreda;Eugenio Santos

  • Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.

    David Matallanas;Victoria Sanz-Moreno;Imanol Arozarena;Fernando Calvo

  • Induction by NGF of meiotic maturation of Xenopus oocytes expressing the trk proto-oncogene product

    Angel R. Nebreda;Dionisio Martin-Zanca;David R. Kaplan;Luis F. Parada

  • The Sos1 and Sos2 Ras-specific exchange factors : differences in placental expression and signaling properties

    Xiaolan Qian;Luis Esteban;William C. Vass;Cheerag Upadhyaya

  • Diversity of Genomic Breakpoints in TFG-ALK Translocations in Anaplastic Large Cell Lymphomas: Identification of a New TFG-ALKXL Chimeric Gene with Transforming Activity

    Luis Hernández;Sílvia Beà;Beatriz Bellosillo;Magda Pinyol

  • Spontaneous activation of a human proto-oncogene.

    E Santos;E P Reddy;S Pulciani;R J Feldmann

Frequent Co-Authors

Mariano Barbacid
Mariano Barbacid Spanish National Cancer Research Centre
José M. López-Novoa
José M. López-Novoa University of Salamanca
Gunter Schumann
Gunter Schumann King's College London
Rainer Spanagel
Rainer Spanagel Heidelberg University
Marjo-Riitta Järvelin
Marjo-Riitta Järvelin Imperial College London
Piero Crespo
Piero Crespo Spanish National Research Council
Wolfgang H. Sommer
Wolfgang H. Sommer Heidelberg University
Leena Peltonen
Leena Peltonen University of Helsinki
Tim D. Spector
Tim D. Spector King's College London

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