World's Best Scientists 2026 revealed!

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Genetics

D-Index
86
Citations
31734
World Ranking
1247
National Ranking
591

Medicine

D-Index
87
Citations
33062
World Ranking
13516
National Ranking
6873

Research.com Recognitions

  • 2015 - Fellow of the Royal Society, United Kingdom
  • 1995 - Fellow of the Royal Society of Edinburgh

Overview

Allan Balmain is affiliated with the University of California, San Francisco in the United States and focuses primarily on research in biochemistry, genetics, and molecular biology, with significant contributions to the fields of medicine.

Their work spans several subfields including molecular biology, cancer research, oncology, pathology and forensic medicine, and physiology. Main research topics include cancer genomics and diagnostics, cancer cells and metastasis, genetic factors in colorectal cancer, single-cell and spatial transcriptomics, cancer-related molecular pathways, cancer, hypoxia, and metabolism, as well as RNA research and splicing.

Recent publications reflect these scientific interests, featuring articles such as:

  • Embracing cancer complexity: Hallmarks of systemic disease (2024) published in Cell
  • The mutational signature profile of known and suspected human carcinogens in mice (2020) published in Nature Genetics
  • The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk (2020) published in Nature Genetics
  • Mutational signatures in tumours induced by high and low energy radiation in Trp53 deficient mice (2020) published in Nature Communications
  • Targeting KRAS4A splicing through the RBM39/DCAF15 pathway inhibits cancer stem cells (2021) published in Nature Communications

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature Communications, Nature Genetics, Cancer Discovery, and Molecular Cancer Research.

Collaboration is an important aspect of their research, with frequent co-authors including Leslie A. Lange, Kyle Halliwill, Jian-Hua Mao, Ludmil B. Alexandrov, and Reyno Delrosario.

Recognition for their work includes being named a Fellow of the Royal Society, United Kingdom in 2015, and a Fellow of the Royal Society of Edinburgh in 1995.

Best Publications

  • TGF-beta signaling in tumor suppression and cancer progression.

    Rik Derynck;Rosemary J. Akhurst;Allan Balmain

  • Guidelines for the welfare and use of animals in cancer research

    P Workman;E O Aboagye;F Balkwill;A Balmain

  • Carcinogen-specific mutation and amplification of Ha- ras during mouse skin carcinogenesis

    Miguel Quintanilla;Ken Brown;Martin Ramsden;Allan Balmain

  • A Mutant-p53/Smad Complex Opposes p63 to Empower TGFβ-Induced Metastasis

    Maddalena Adorno;Michelangelo Cordenonsi;Marco Montagner;Sirio Dupont

  • TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

    Wei Cui;Deborah J Fowlis;Sheila Bryson;Elizabeth Duffie

  • The genetics and genomics of cancer

    Allan Balmain;Joe Gray;Bruce Ponder

  • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice.

    Anita J. Merritt;Christopher S. Potten;Christopher J. Kemp;John A. Hickman

  • Activation of the mouse cellular Harvey- ras gene in chemically induced benign skin papillomas

    Allan Balmain;Martin Ramsden;George T. Bowden;John Smith

  • Mouse skin carcinomas induced in vivo by chemical carcinogens have a transforming Harvey-ras oncogene.

    Allan Balmain;Ian B. Pragnell

  • Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors.

    Christopher J. Kemp;Lawrence A. Donehower;Allan Bradley;Allan Balmain

  • FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression.

    Jian-Hua Mao;Il-Jin Kim;Di Wu;Joan Climent

  • Oncogene activation in chemical carcinogenesis.

    Allan Balmain;Ken Brown

  • p53 -deficient mice are extremely susceptible to radiation-induced tumorigenesis

    Christopher J. Kemp;Tom Wheldon;Allan Balmain

  • Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

    Martin Oft;Rosemary J. Akhurst;Rosemary J. Akhurst;Allan Balmain;Allan Balmain

  • UKCCCR guidelines for the welfare of animals in experimental neoplasia.

    P Workman;A Balmain;J A Hickman;N J McNally

  • Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human

    Amanda Ewart-Toland;Paraskevi Briassouli;John P de Koning;John P de Koning;Jian-Hua Mao

  • Fbxw7 / Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

    Jian-Hua Mao;Jesus Perez-losada;Di Wu;Reyno DelRosario

  • Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter.

    B Bailleul;M A Surani;S White;S C Barton

  • Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression

    Ken Brown;Albrecht Buchmann;Allan Balmain

  • Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

    R J Akhurst;F Fee;A Balmain

Frequent Co-Authors

Jian-Hua Mao
Jian-Hua Mao Lawrence Berkeley National Laboratory
Rosemary J. Akhurst
Rosemary J. Akhurst University of California, San Francisco
Christopher J. Kemp
Christopher J. Kemp Fred Hutchinson Cancer Research Center
Miguel Quintanilla
Miguel Quintanilla Spanish National Research Council
Vessela N. Kristensen
Vessela N. Kristensen Oslo University Hospital
Anne Lise Børresen-Dale
Anne Lise Børresen-Dale Oslo University Hospital
Joe W. Gray
Joe W. Gray Oregon Health & Science University
Rod Bremner
Rod Bremner Lunenfeld-Tanenbaum Research Institute
David J. Adams
David J. Adams Wellcome Sanger Institute
Frank McCormick
Frank McCormick University of California, San Francisco

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