D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 54 Citations 17,523 105 World Ranking 10829 National Ranking 4683

Overview

What is she best known for?

The fields of study she is best known for:

  • Gene
  • Cancer
  • Genetics

The scientist’s investigation covers issues in Cell biology, Transforming growth factor beta, Carcinogenesis, Transforming growth factor, beta 3 and Transforming growth factor. Her Cell biology research is multidisciplinary, incorporating perspectives in Internal medicine and Endocrinology. In her study, Kinase, Molecular biology and Kinase activity is strongly linked to Cancer cell, which falls under the umbrella field of Transforming growth factor beta.

The Carcinogenesis study combines topics in areas such as Tumor progression, Cancer research and Carcinoma. Her Transforming growth factor, beta 3 study combines topics from a wide range of disciplines, such as TGF beta signaling pathway, TGF beta receptor 2 and TGF beta 1. Rosemary J. Akhurst has included themes like Vasculogenesis and Immunology in her TGF beta signaling pathway study.

Her most cited work include:

  • TGF-beta signaling in tumor suppression and cancer progression. (1950 citations)
  • Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice (923 citations)
  • Targeting the TGFβ signalling pathway in disease. (890 citations)

What are the main themes of her work throughout her whole career to date?

Her primary areas of investigation include Transforming growth factor, Cancer research, Cell biology, Transforming growth factor beta and Genetics. Her research integrates issues of DNA damage, Receptor, Autocrine signalling, In situ hybridization and ITGB8 in her study of Transforming growth factor. Her work carried out in the field of Cancer research brings together such families of science as Carcinogenesis, Cancer, Epithelial–mesenchymal transition and Signal transduction.

Her studies in Cell biology integrate themes in fields like Endothelial stem cell, Transforming growth factor, beta 3, Internal medicine and Endocrinology. The various areas that Rosemary J. Akhurst examines in her Transforming growth factor beta study include Immunology, TGF beta signaling pathway, Molecular biology, Knockout mouse and Metastasis. Her Immunology research incorporates themes from Yolk sac and Haematopoiesis.

She most often published in these fields:

  • Transforming growth factor (34.58%)
  • Cancer research (32.71%)
  • Cell biology (36.45%)

What were the highlights of her more recent work (between 2012-2021)?

  • Cancer research (32.71%)
  • Transforming growth factor (34.58%)
  • Cancer (14.95%)

In recent papers she was focusing on the following fields of study:

Cancer research, Transforming growth factor, Cancer, Cell biology and Signal transduction are her primary areas of study. Her Cancer research study integrates concerns from other disciplines, such as Genetic variation and Immunotherapy. Her research in Transforming growth factor intersects with topics in Stromal cell and ITGB8.

Her Cancer study also includes fields such as

  • Immune system that intertwine with fields like Cervical cancer, Cell and Clinical significance,
  • Stem cell that intertwine with fields like Cancer cell, Carcinoma, Cell culture and Carcinogenesis. Rosemary J. Akhurst has researched Cell biology in several fields, including Endothelial stem cell, Epithelial–mesenchymal transition, Reprogramming and Autocrine signalling. Her primary area of study in Signal transduction is in the field of Transforming growth factor beta.

Between 2012 and 2021, her most popular works were:

  • Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. (70 citations)
  • Targeting TGF-β Signaling for Therapeutic Gain (66 citations)
  • Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain (60 citations)

In her most recent research, the most cited papers focused on:

  • Gene
  • Cancer
  • Genetics

The scientist’s investigation covers issues in Transforming growth factor, Cancer research, Cancer, Signal transduction and Immunotherapy. Her Transforming growth factor research focuses on Transforming growth factor beta in particular. Her study in Cancer research is interdisciplinary in nature, drawing from both Cancer stem cell, Stem cell, Blockade, Transmembrane protein and PI3K/AKT/mTOR pathway.

Her Cancer research incorporates elements of Fibrosis, Receptor and Cell type. Her Signal transduction research is multidisciplinary, relying on both SUPERFAMILY, Tgfβ superfamily and Bioinformatics. Her biological study spans a wide range of topics, including Epithelial–mesenchymal transition and T cell.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

TGF-beta signaling in tumor suppression and cancer progression.

Rik Derynck;Rosemary J. Akhurst;Allan Balmain.
Nature Genetics (2001)

3252 Citations

Targeting the TGFβ signalling pathway in disease.

Rosemary J. Akhurst;Akiko Hata.
Nature Reviews Drug Discovery (2012)

1290 Citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice

Marion C. Dickson;Julie S. Martin;Frances M. Cousins;Ashok B. Kulkarni.
Development (1995)

1285 Citations

TGF-β signaling in cancer – a double-edged sword

Rosemary J Akhurst;Rik Derynck.
Trends in Cell Biology (2001)

1012 Citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

Wei Cui;Deborah J Fowlis;Sheila Bryson;Elizabeth Duffie.
Cell (1996)

870 Citations

Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo.

F.A. Millan;F. Denhez;P. Kondaiah;R.J. Akhurst.
Development (1991)

669 Citations

Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

Martin Oft;Rosemary J. Akhurst;Rosemary J. Akhurst;Allan Balmain;Allan Balmain.
Nature Cell Biology (2002)

502 Citations

Differentiation plasticity regulated by TGF-β family proteins in development and disease

Rik Derynck;Rosemary J. Akhurst.
Nature Cell Biology (2007)

455 Citations

Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action.

S.A. Lehnert;R.J. Akhurst.
Development (1988)

452 Citations

Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

R J Akhurst;F Fee;A Balmain.
Nature (1988)

359 Citations

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