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Biology and Biochemistry

D-Index
58
Citations
20636
World Ranking
12921
National Ranking
5503

Overview

Rosemary J. Akhurst is affiliated with the University of California, San Francisco in the United States. Their work primarily focuses on several intersecting fields, including Medicine and Biochemistry, Genetics and Molecular Biology. Within these broader areas, their research emphasizes Oncology, Molecular Biology, and Immunology.

The scientist's research addresses key topics such as Cancer Cells and Metastasis, TGF-β signaling in diseases, Immunotherapy and Immune Responses, Cancer Research and Treatments, Cell Adhesion Molecules Research, T-cell and B-cell Immunology, and Single-cell and spatial transcriptomics.

Rosemary J. Akhurst has contributed publications in a range of venues. Frequent publication outlets include bioRxiv (Cold Spring Harbor Laboratory), where they have four publications. Other venues with notable publications are Nature Reviews Clinical Oncology, Cell Reports, Seminars in Cancer Biology, and Annual Review of Cancer Biology.

Their recent research papers include:

  • "From shape-shifting embryonic cells to oncology: The fascinating history of epithelial mesenchymal transition," 2023, Seminars in Cancer Biology
  • "TGFβ: Signaling Blockade for Cancer Immunotherapy," 2021, Annual Review of Cancer Biology
  • "Integrin αvβ8 on T cells suppresses anti-tumor immunity in multiple models and is a promising target for tumor immunotherapy," 2021, Cell Reports
  • "TGFβ biology in cancer progression and immunotherapy," 2020, Nature Reviews Clinical Oncology
  • "Executive summary of the 14th HHT international scientific conference," 2023, Angiogenesis

Rosemary J. Akhurst has collaborated frequently with several researchers, including Allan Balmain, Eswari Dodagatta-Marri, Hsiao-Yen Ma, Benjia Liang, and John Li. Among these, collaborations with Allan Balmain have been most prolific with five joint works.

Best Publications

  • TGF-beta signaling in tumor suppression and cancer progression.

    Rik Derynck;Rosemary J. Akhurst;Allan Balmain

  • Targeting the TGFβ signalling pathway in disease.

    Rosemary J. Akhurst;Akiko Hata

  • Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice

    Marion C. Dickson;Julie S. Martin;Frances M. Cousins;Ashok B. Kulkarni

  • TGF-β signaling in cancer – a double-edged sword

    Rosemary J Akhurst;Rik Derynck

  • TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

    Wei Cui;Deborah J Fowlis;Sheila Bryson;Elizabeth Duffie

  • Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo.

    F.A. Millan;F. Denhez;P. Kondaiah;R.J. Akhurst

  • TGFβ biology in cancer progression and immunotherapy.

    Rik Derynck;Shannon J. Turley;Rosemary J. Akhurst

  • Metastasis is driven by sequential elevation of H-ras and Smad2 levels.

    Martin Oft;Rosemary J. Akhurst;Rosemary J. Akhurst;Allan Balmain;Allan Balmain

  • Differentiation plasticity regulated by TGF-β family proteins in development and disease

    Rik Derynck;Rosemary J. Akhurst

  • Embryonic expression pattern of TGF beta type-1 RNA suggests both paracrine and autocrine mechanisms of action.

    S.A. Lehnert;R.J. Akhurst

  • Complexities of TGF-β Targeted Cancer Therapy

    Erin C. Connolly;Julia Freimuth;Rosemary J. Akhurst

  • TGF-β-induced activation of mTOR complex 2 drives epithelial–mesenchymal transition and cell invasion

    S. Lamouille;E. Connolly;J. W. Smyth;R. J. Akhurst

  • Localized production of TGF-β mRNA in tumour promoter-stimulated mouse epidermis

    R J Akhurst;F Fee;A Balmain

  • Differential expression of TGF beta isoforms in murine palatogenesis

    David FitzPatrick;F Denhez;P Kondaiah;R J Akhurst

  • Differentiation plasticity regulated by TGF-|[beta]| family proteins in development and disease

    Rik Derynck;Rosemary J. Akhurst

  • TGF beta in murine morphogenetic processes : the early embryo and cardiogenesis

    R.J. Akhurst;S.A. Lehnert;A. Faissner;E. Duffie

  • Transforming growth factor beta is essential for spindle cell conversion of mouse skin carcinoma in vivo: implications for tumor invasion.

    G Portella;S A Cumming;J Liddell;W Cui

  • TGFβ1 Inhibition Increases the Radiosensitivity of Breast Cancer Cells In Vitro and Promotes Tumor Control by Radiation In Vivo

    Fanny Bouquet;Anupama Pal;Karsten A. Pilones;Sandra Demaria

  • Transforming growth factor-β in breast cancer: too much, too late

    Mary Helen Barcellos-Hoff;Rosemary J Akhurst

  • Genetic events and the role of TGFβ in epithelial tumour progression

    Rosemary J. Akhurst;Allan Balmain;Allan Balmain

Frequent Co-Authors

Allan Balmain
Allan Balmain University of California, San Francisco
Rik Derynck
Rik Derynck University of California, San Francisco
Dean Sheppard
Dean Sheppard University of California, San Francisco
Sigrid A. Lehnert
Sigrid A. Lehnert Commonwealth Scientific and Industrial Research Organisation
Gaetan Lesca
Gaetan Lesca Claude Bernard University Lyon 1
Christopher J. Kemp
Christopher J. Kemp Fred Hutchinson Cancer Research Center
Michael Rosenblum
Michael Rosenblum University of California, San Francisco
Christopher C.W. Hughes
Christopher C.W. Hughes University of California, Irvine
Eric H. Davidson
Eric H. Davidson California Institute of Technology
Roy J. Britten
Roy J. Britten California Institute of Technology

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