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D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
23157
World Ranking
6185
National Ranking
2911

Overview

Christopher C.W. Hughes is affiliated with the University of California, Irvine in the United States. Their research spans several interconnected fields including Medicine and Biochemistry, Genetics and Molecular Biology, with a focus on subfields such as Molecular Biology, Biomedical Engineering, Oncology, Surgery, and Cancer Research.

The scientist's main topics of work encompass areas related to biomedical innovation and cancer biology. These include:

  • 3D Printing in Biomedical Research
  • Cancer Cells and Metastasis
  • Angiogenesis and VEGF in Cancer
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Pancreatic function and diabetes
  • Diabetes and associated disorders
  • Cancer Genomics and Diagnostics

Christopher C.W. Hughes has contributed to several peer-reviewed papers, some of which have been cited extensively. Representative recent publications include:

  • Engineering Vascularized Organoid-on-a-Chip Models, 2021, Annual Review of Biomedical Engineering
  • An in vitro vascularized micro-tumor model of human colorectal cancer recapitulates in vivo responses to standard-of-care therapy, 2021, Lab on a Chip
  • Tumor-on-chip modeling of organ-specific cancer and metastasis, 2021, Advanced Drug Delivery Reviews
  • Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis, 2020, Nature Communications
  • Regulation of Partial and Reversible Endothelial-to-Mesenchymal Transition in Angiogenesis, 2021, Frontiers in Cell and Developmental Biology

Frequent co-authors in Christopher C.W. Hughes's publications include:

  • Stephanie J. Hachey
  • Christopher J. Hatch
  • Steven C. George
  • Jennifer S. Fang
  • Abraham P. Lee

The scientist has published in multiple venues, with higher concentrations of work appearing in the following journals:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Lab on a Chip
  • Cell Reports
  • Frontiers in Cell and Developmental Biology
  • Annals of Surgical Oncology

Best Publications

  • Of mice and not men: differences between mouse and human immunology

    Javier Mestas;Christopher C. W. Hughes

  • Consensus guidelines for the use and interpretation of angiogenesis assays

    Patrycja Nowak-Sliwinska;Kari Alitalo;Elizabeth Allen;Andrey Anisimov

  • CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression.

    Karin Karmann;Christopher C. W. Hughes;Jeffrey Schechner;William C. Fanslow

  • Angiogenic sprouting and capillary lumen formation modeled by human umbilical vein endothelial cells (HUVEC) in fibrin gels: the role of fibroblasts and Angiopoietin-1.

    Martin N. Nakatsu;Richard C.A. Sainson;Jason N. Aoto;Kevin L. Taylor

  • A conserved mechanism for steroid receptor translocation to the plasma membrane.

    Ali Pedram;Mahnaz Razandi;Richard C.A. Sainson;Jin K. Kim

  • The requirement for fibroblasts in angiogenesis: fibroblast-derived matrix proteins are essential for endothelial cell lumen formation.

    Andrew C. Newman;Martin N. Nakatsu;Wayne Chou;Paul D. Gershon

  • In Vitro Perfused Human Capillary Networks

    Monica L. Moya;Yu-Hsiang Hsu;Abraham P. Lee;Christopher C.W. Hughes

  • Diffusion limits of an in vitro thick prevascularized tissue.

    Craig K. Griffith;Cheryl Miller;Richard C.A. Sainson;Jay W. Calvert

  • Human coronary transplantation-associated arteriosclerosis. Evidence for a chronic immune reaction to activated graft endothelial cells.

    R. N. Salomon;C. C. Hughes;F. J. Schoen;D. D. Payne

  • Wnt Signaling Induces Matrix Metalloproteinase Expression and Regulates T Cell Transmigration

    Beibei Wu;Steve P. Crampton;Christopher C.W. Hughes

  • In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse.

    J. S. Schechner;A. K. Nath;L. Zheng;M. S. Kluger

  • Development and characterisation of a rat brain capillary endothelial culture: towards an in vitro blood-brain barrier

    N. J. Abbott;C. C. W. Hughes;P. A. Revest;J. Greenwood

  • 3D microtumors in vitro supported by perfused vascular networks

    Agua Sobrino;Duc T. T. Phan;Rupsa Datta;Xiaolin Wang

  • B7-H1 Is Expressed by Human Endothelial Cells and Suppresses T Cell Cytokine Synthesis

    Melissa M. Mazanet;Christopher C. W. Hughes

  • Prevascularization of a fibrin-based tissue construct accelerates the formation of functional anastomosis with host vasculature.

    Xiaofang Chen;Anna S. Aledia;Cyrus M. Ghajar;Craig K. Griffith

  • Crosstalk Between Vascular Endothelial Growth Factor, Notch, and Transforming Growth Factor-β in Vascular Morphogenesis

    Matthew T. Holderfield;Christopher C.W. Hughes

  • TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype.

    Richard C. A. Sainson;Douglas A. Johnston;Henry C. Chu;Matthew T. Holderfield

  • Integration of the Non-genomic and Genomic Actions of Estrogen: MEMBRANE-INITIATED SIGNALING BY STEROID TO TRANSCRIPTION AND CELL BIOLOGY *

    Ali Pedram;Mahnaz Razandi;Mark Aitkenhead;Mark Aitkenhead;Christopher C.W. Hughes;Christopher C.W. Hughes

  • An optimized three-dimensional in vitro model for the analysis of angiogenesis.

    Martin N. Nakatsu;Christopher C.W. Hughes

  • The Effect of Matrix Density on the Regulation of 3-D Capillary Morphogenesis

    Cyrus M. Ghajar;Xiaofang Chen;Joseph W. Harris;Vinod Suresh

Frequent Co-Authors

Abraham P. Lee
Abraham P. Lee University of California, Irvine
Jordan S. Pober
Jordan S. Pober Yale University
Marian L. Waterman
Marian L. Waterman University of California, Irvine
Rolf A. Brekken
Rolf A. Brekken The University of Texas Southwestern Medical Center
John Lowengrub
John Lowengrub University of California, Irvine
Steven Z. George
Steven Z. George Duke University
Philip W. Askenase
Philip W. Askenase Yale University
Noo Li Jeon
Noo Li Jeon Seoul National University
Andrew J. Putnam
Andrew J. Putnam University of Michigan–Ann Arbor
Gaetan Lesca
Gaetan Lesca Claude Bernard University Lyon 1

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