World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
96
Citations
33091
World Ranking
9684
National Ranking
4985

Overview

Rolf A. Brekken is affiliated with The University of Texas Southwestern Medical Center in the United States. Their research spans multiple domains within biomedical sciences, with a particular emphasis on oncology, immunology, and molecular biology.

The main fields of study for their work include Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. Among the subfields, Oncology, Immunology, Molecular Biology, Cancer Research, and Cell Biology are prominent areas of contribution.

The scientist's research topics cover a range of critical issues in cancer biology and immune regulation. Notable areas of focus include:

  • Pancreatic and Hepatic Oncology Research
  • Phagocytosis and Immune Regulation
  • Immune cells in cancer
  • Cancer Immunotherapy and Biomarkers
  • Cancer Cells and Metastasis
  • Single-cell and spatial transcriptomics
  • Angiogenesis and VEGF in Cancer

Among recent publications, several highlight their involvement in advancing the understanding of tumor microenvironments and cancer-associated immune mechanisms. Some of the noted works are:

  • "Pancreatic cancer stroma: an update on therapeutic targeting strategies," 2020, Nature Reviews Gastroenterology & Hepatology
  • "Mesothelial cell-derived antigen-presenting cancer-associated fibroblasts induce expansion of regulatory T cells in pancreatic cancer," 2022, Cancer Cell
  • "DDR1-induced neutrophil extracellular traps drive pancreatic cancer metastasis," 2021, JCI Insight
  • "The Colorectal Cancer Tumor Microenvironment and Its Impact on Liver and Lung Metastasis," 2021, Cancers
  • "Cancer-Associated Fibroblasts: Versatile Players in the Tumor Microenvironment," 2020, Cancers

Frequent collaborators in their research include Huocong Huang, Jason E. Toombs, Debolina Ganguly, James B. Lorens, and John D. Minna, reflecting ongoing partnerships in advancing cancer research and immunology.

Their work has been published in key scientific venues that include:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancers
  • Journal of Clinical Oncology
  • JCI Insight

Best Publications

  • Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

    Gabriele Bergers;Rolf Brekken;Gerald McMahon;Thiennu H. Vu

  • Hypoxia-inducible factor 1α induces fibrosis and insulin resistance in white adipose tissue

    Nils Halberg;Tayeba Khan;Maria E. Trujillo;Maria E. Trujillo;Ingrid Wernstedt-Asterholm

  • SPARC, a matricellular protein: at the crossroads of cell-matrix.

    Rolf A. Brekken;E.Helene Sage

  • COMPOSITIONS AND METHODS FOR CANCER TREATMENT BY SELECTIVELY INHIBITING VEGF (VASCULAR ENDOTHELIAL GROWTH FACTOR)

    Thorpe Philip E;Brekken Rolf A

  • SPARC, a matricellular protein: at the crossroads of cell-matrix communication.

    Rolf A Brekken;E. H. Sage

  • Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer

    R. B. Birge;S. Boeltz;S. Kumar;J. Carlson

  • Pancreatic cancer stroma: an update on therapeutic targeting strategies.

    Abdel N. Hosein;Abdel N. Hosein;Rolf A. Brekken;Anirban Maitra

  • Role of VEGF-A in Vascularization of Pancreatic Islets

    Eckhard Lammert;Guqiang Gu;Margaret McLaughlin;Dennis Brown

  • Selective Inhibition of Vascular Endothelial Growth Factor (VEGF) Receptor 2 (KDR/Flk-1) Activity by a Monoclonal Anti-VEGF Antibody Blocks Tumor Growth in Mice

    Rolf A. Brekken;Jay P. Overholser;Victor A. Stastny;Johannes Waltenberger

  • Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth

    Romulo J C Albuquerque;Takahiko Hayashi;Won Gil Cho;Mark E Kleinman

  • Dichotomous effects of VEGF-A on adipose tissue dysfunction

    Kai Sun;Ingrid Wernstedt Asterholm;Christine M. Kusminski;Ana Carolina Bueno;Ana Carolina Bueno

  • Soluble Eph A receptors inhibit tumor angiogenesis and progression in vivo.

    Dana M Brantley;Nikki Cheng;Erin J Thompson;Qing Lin

  • 27-Hydroxycholesterol Promotes Cell-Autonomous, ER-Positive Breast Cancer Growth

    Qian Wu;Tomonori Ishikawa;Rosa Sirianni;Hao Tang

  • Angiogenic Role of LYVE-1-positive Macrophages in Adipose Tissue

    Chung Hyun Cho;Chung Hyun Cho;Young Jun Koh;Jinah Han;Hoon Ki Sung

  • Monitoring Response to Anticancer Therapy by Targeting Microbubbles to Tumor Vasculature

    Grzegorz Korpanty;Juliet G. Carbon;Paul A. Grayburn;Jason B. Fleming

  • A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

    Lei Wang;Jianjun Chang;Diana Varghese;Michael T Dellinger

  • Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single-cell resolution.

    Abdel Nasser Hosein;Huocong Huang;Zhaoning Wang;Kamalpreet Parmar

  • A Peptoid "Antibody Surrogate" That Antagonizes VEGF Receptor 2 Activity

    D. Gomika Udugamasooriya;Sean P. Dineen;Rolf A. Brekken;Thomas Kodadek

  • Enhanced Expression of SPARC/Osteonectin in the Tumor-associated Stroma of Non-Small Cell Lung Cancer Is Correlated with Markers of Hypoxia/ Acidity and with Poor Prognosis of Patients

    Michael I. Koukourakis;Alexandra Giatromanolaki;Rolf A. Brekken;Efthimios Sivridis

  • Non-nuclear estrogen receptor α signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

    Ken L. Chambliss;Qian Wu;Sarah Oltmann;Eddy S. Konaniah

Frequent Co-Authors

John D. Minna
John D. Minna The University of Texas Southwestern Medical Center
Jason B. Fleming
Jason B. Fleming The University of Texas MD Anderson Cancer Center
Philip E. Thorpe
Philip E. Thorpe The University of Texas Southwestern Medical Center
Luc Girard
Luc Girard The University of Texas Southwestern Medical Center
Adi F. Gazdar
Adi F. Gazdar The University of Texas Southwestern Medical Center
Michael A. White
Michael A. White Ideaya Biosciences (United States)
E. Helene Sage
E. Helene Sage Benaroya Research Institute
Ralph J. DeBerardinis
Ralph J. DeBerardinis The University of Texas Southwestern Medical Center
Pauli Puolakkainen
Pauli Puolakkainen University of Helsinki
Diego H. Castrillon
Diego H. Castrillon The University of Texas Southwestern Medical Center

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring alternative routes in the healthcare field can open up flexible and affordable career options. Many programs now offer fully online degrees and certificates, allowing students to balance work and study from anywhere in the world.

For registered nurses looking to advance, the cheapest bsn to dnp programs offer streamlined and budget-friendly paths to higher-level nursing roles. Similarly, those interested in pharmacy can consider pharm d online programs, which are designed for working professionals aiming to become licensed pharmacists.

Technology-savvy students might find opportunities in the digital management of health records. A health information technology online degree prepares graduates for in-demand roles managing patient data and health information systems.

Meanwhile, those seeking quick entry into the healthcare workforce may consider medical coding. If you’re wondering how much is medical billing and coding school, there are cost-effective online options to get certified and start working fast.

Best Scientists Citing Rolf A. Brekken

Trending Scientists