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Chemistry

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72
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Biology and Biochemistry

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Research.com Recognitions

  • 2016 - Fellow, National Academy of Inventors
  • 2006 - National Institutes of Health Director's Pioneer Award
  • 1999 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Thomas Kodadek is affiliated with the Scripps Research Institute in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, with a focus on Molecular Biology, Organic Chemistry, Oncology, Radiology, Nuclear Medicine and Imaging, and Biomaterials.

Their work extensively covers topics including Chemical Synthesis and Analysis, Ubiquitin and proteasome pathways, Protein Degradation and Inhibitors, Click Chemistry and Applications, Monoclonal and Polyclonal Antibodies Research, Peptidase Inhibition and Analysis, and advanced biosensing and bioanalysis techniques.

Key frequent co-authors include Weijun Gui, Animesh Roy, Nicholas G. Paciaroni, Eric Koesema, and Madeline Balzarini.

Thomas Kodadek has published regularly in several venues. The most frequent publication venues are bioRxiv (Cold Spring Harbor Laboratory), Angewandte Chemie, Angewandte Chemie International Edition, Chemical Communications, and Cell chemical biology.

Among recent papers authored or co-authored by Thomas Kodadek are:

  • Solid-phase synthesis of DNA-encoded libraries via an "aldehyde explosion" strategy, 2020, Chemical Communications
  • Synthesis and Screening of a DNA-Encoded Library of Non-Peptidic Macrocycles, 2022, Angewandte Chemie International Edition
  • Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190, 2020, Cell chemical biology
  • High-Throughput Quality Control Assay for the Solid-Phase Synthesis of DNA-Encoded Libraries of Macrocycles, 2021, Angewandte Chemie International Edition
  • Reversible Assembly of Proteolysis Targeting Chimeras, 2023, ACS Chemical Biology

Throughout their career, Thomas Kodadek has received several awards, including the National Institutes of Health Director's Pioneer Award in 2006, election as a Fellow of the American Association for the Advancement of Science (AAAS) in 1999, and the honor of Fellow, National Academy of Inventors in 2016.

Best Publications

  • Chemistry for the analysis of protein-protein interactions: rapid and efficient cross-linking triggered by long wavelength light.

    David A. Fancy;Thomas Kodadek

  • Protein microarrays: prospects and problems

    Thomas Kodadek

  • Recruitment of a 19S Proteasome Subcomplex to an Activated Promoter

    Fernando Gonzalez;Agnes Delahodde;Thomas Kodadek;Stephen Albert Johnston

  • Genome-wide analysis of chromatin regulation by cocaine reveals a role for sirtuins.

    William Renthal;Arvind Kumar;Guanghua Xiao;Matthew Wilkinson

  • TATA Element Recognition by the TATA Box-Binding Protein Has Been Conserved Throughout Evolution

    Georgia A. Patikoglou;Joseph L. Kim;Liping Sun;Sang-Hwa Yang

  • The 19S Regulatory Particle of the Proteasome Is Required for Efficient Transcription Elongation by RNA Polymerase II

    Anwarul Ferdous;Fernando Gonzalez;Liping Sun;Thomas Kodadek

  • SHAPE AND STEREOSELECTIVE CYCLOPROPANATION OF ALKENES CATALYZED BY IRON PORPHYRINS

    Jennifer Robbins Wolf;Christopher G. Hamaker;Jean-Pierre Djukic;Thomas Kodadek

  • Imipramine treatment and resiliency exhibit similar chromatin regulation in the mouse nucleus accumbens in depression models.

    Matthew B. Wilkinson;Guanghua Xiao;Arvind Kumar;Arvind Kumar;Quincey LaPlant

  • Isolation of Protein Ligands from Large Peptoid Libraries

    Prasanna G. Alluri;M. Muralidhar Reddy;Kiran Bachhawat-Sikder;Hernando J. Olivos

  • Peptoids as potential therapeutics.

    Ronald N Zuckermann;Thomas Kodadek

  • A Peptoid "Antibody Surrogate" That Antagonizes VEGF Receptor 2 Activity

    D. Gomika Udugamasooriya;Sean P. Dineen;Rolf A. Brekken;Thomas Kodadek

  • Epoxidation of olefins by cytochrome P-450 model compounds: kinetics and stereochemistry of oxygen atom transfer and origin of shape selectivity

    James P. Collman;John I. Brauman;Bernard Meunier;Teruyuki Hayashi

  • Target Identification in Chemical Genetics: The (Often) Missing Link

    Lyle Burdine;Thomas Kodadek

  • Identification of Candidate IgG Biomarkers for Alzheimer's Disease via Combinatorial Library Screening

    M. Muralidhar Reddy;M. Muralidhar Reddy;Rosemary Wilson;Johnnie Wilson;Steven Connell

  • DMC1 functions in a Saccharomyces cerevisiae meiotic pathway that is largely independent of the RAD51 pathway.

    Michael E. Dresser;Debra J. Ewing;Michael N. Conrad;Ana M. Dominguez

  • Quantitative evaluation of the relative cell permeability of peptoids and peptides

    Yong Uk Kwon;Thomas Kodadek

  • Microwave-assisted solid-phase synthesis of peptoids.

    Hernando J. Olivos;Prasanna G. Alluri;M. Muralidhar Reddy;Derek Salony

  • The acidic activation domains of the GCN4 and GAL4 proteins are not α helical but form β sheets

    Michael Van Hoy;Kerstin K. Leuther;Thomas Kodadek;Stephen A. Johnston

  • Direct Association between the Yeast Rad51 and Rad54 Recombination Proteins

    Hua Jiang;Yueqing Xie;Peter Houston;Katherine Stemke-Hale

  • Physical and functional association of RNA polymerase II and the proteasome

    Thomas G. Gillette;Fernando Gonzalez;Agnes Delahodde;Stephen Albert Johnston

Frequent Co-Authors

Stephen Albert Johnston
Stephen Albert Johnston Arizona State University
John I. Brauman
John I. Brauman Stanford University
Rolf A. Brekken
Rolf A. Brekken The University of Texas Southwestern Medical Center
Benjamin F. Cravatt
Benjamin F. Cravatt Scripps Research Institute
A. Dean Sherry
A. Dean Sherry The University of Texas Southwestern Medical Center
James P. Collman
James P. Collman Stanford University
Cheng Ming Chiang
Cheng Ming Chiang The University of Texas Southwestern Medical Center
Eric J. Nestler
Eric J. Nestler Icahn School of Medicine at Mount Sinai
Bernard Meunier
Bernard Meunier Guangdong University of Technology
Christoph Rader
Christoph Rader Scripps Research Institute

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