World's Best Scientists 2026 revealed!

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Chemistry

D-Index
52
Citations
11928
World Ranking
13409
National Ranking
3513

Biology and Biochemistry

D-Index
57
Citations
14278
World Ranking
13658
National Ranking
5796

Overview

Gal Bitan is affiliated with the University of California, Los Angeles in the United States. Their research primarily spans the field of Medicine, with a strong focus on Neurology, Molecular Biology, Physiology, Cell Biology, and Pharmacology. The work emphasizes neurological disorders and their underlying mechanisms, involving cellular and molecular studies.

The main topics in Gal Bitan's research include:

  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Neurological disorders and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Cholinesterase and Neurodegenerative Diseases
  • Extracellular vesicles in disease
  • Cellular transport and secretion

Gal Bitan has published extensively in several scientific venues, with frequent contributions to the following journals:

  • Journal of Biological Chemistry
  • Acta Neuropathologica
  • Alzheimer's Research & Therapy
  • ACS Chemical Neuroscience
  • Alzheimer's & Dementia

Among their recent publications are:

  • CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges, 2020, Frontiers in Molecular Neuroscience
  • α-Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinson's disease from multiple system atrophy, 2021, Acta Neuropathologica
  • Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges, 2023, Acta Neuropathologica
  • CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease, 2020, Nature Communications
  • Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers, 2020, Journal of the American Chemical Society

Frequent collaborators include researchers such as Lila M. Gierasch, F. Peter Guengerich, Ruma Banerjee, Roger Colbran, and Peter Cresswell. Each of these coauthors has collaborated with Bitan on multiple occasions, illustrating a consistent network of scientific cooperation.

Best Publications

  • Amyloid beta -protein (Abeta) assembly: Abeta 40 and Abeta 42 oligomerize through distinct pathways.

    Gal Bitan;Marina D. Kirkitadze;Aleksey Lomakin;Sabrina S. Vollers

  • Amyloid-β protein oligomerization and the importance of tetramers and dodecamers in the aetiology of Alzheimer's disease

    Summer L. Bernstein;Nicholas F. Dupuis;Noel D. Lazo;Thomas Wyttenbach

  • Paradigm shifts in Alzheimer's disease and other neurodegenerative disorders: the emerging role of oligomeric assemblies.

    Marina D. Kirkitadze;Gal Bitan;Gal Bitan;David B. Teplow;David B. Teplow

  • Amyloid β-Protein Oligomerization PRENUCLEATION INTERACTIONS REVEALED BY PHOTO-INDUCED CROSS-LINKING OF UNMODIFIED PROTEINS

    Gal Bitan;Aleksey Lomakin;David B. Teplow

  • Amyloid β-protein: Monomer structure and early aggregation states of Aβ42 and its Pro19 alloform

    Summer L Bernstein;Thomas Wyttenbach;Andrij Baumketner;Joan-Emma Shea

  • In silico study of amyloid β-protein folding and oligomerization

    B. Urbanc;L. Cruz;S. Yun;S. V. Buldyrev

  • Increased T cell reactivity to amyloid β protein in older humans and patients with Alzheimer disease

    Alon Monsonego;Victor Zota;Arnon Karni;Jeffery I. Krieger

  • Elucidation of Primary Structure Elements Controlling Early Amyloid β-Protein Oligomerization

    Gal Bitan;Sabrina S. Vollers;David B. Teplow

  • Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

    Sharmistha Sinha;Dahabada H. J. Lopes;Zhenming Du;Eric S. Pang

  • Amyloid beta-protein monomer structure: a computational and experimental study.

    Andrij Baumketner;Summer L. Bernstein;Thomas Wyttenbach;Gal Bitan

  • Neurotoxic protein oligomers — what you see is not always what you get

    Gal Bitan;Erica A Fradinger;Sean M Spring;David B Teplow

  • Elucidating Amyloid β-Protein Folding and Assembly: A Multidisciplinary Approach

    David B Teplow;Noel D Lazo;Gal Bitan;Summer Bernstein

  • Elucidation of amyloid beta-protein oligomerization mechanisms: discrete molecular dynamics study

    B Urbanc;M Betnel;L Cruz;G Bitan

  • Rapid photochemical cross-linking--a new tool for studies of metastable, amyloidogenic protein assemblies.

    Gal Bitan;David B. Teplow

  • C-terminal peptides coassemble into Aβ42 oligomers and protect neurons against Aβ42-induced neurotoxicity

    Erica A. Fradinger;Bernhard H. Monien;Brigita Urbanc;Aleksey Lomakin

  • A Molecular Switch in Amyloid Assembly: Met35 and Amyloid β-Protein Oligomerization

    Gal Bitan;Bogdan Tarus;Sabrina S. Vollers;Hilal A. Lashuel

  • CNS-Derived Blood Exosomes as a Promising Source of Biomarkers: Opportunities and Challenges

    Simon Hornung;Suman Dutta;Gal Bitan

  • A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease.

    Aida Attar;Tingyu Liu;Wai-Ting Coco Chan;Jane Hayes

  • A Novel "Molecular Tweezer" Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

    Shubhangi Prabhudesai;Sharmistha Sinha;Aida Attar;Aswani Kotagiri

  • Role of Electrostatic Interactions in Amyloid β-Protein (Aβ) Oligomer Formation: A Discrete Molecular Dynamics Study

    Sijung Yun;B. Urbanc;L. Cruz;G. Bitan

  • Photoaffinity cross-linking identifies differences in the interactions of an agonist and an antagonist with the parathyroid hormone/parathyroid hormone-related protein receptor.

    Vered Behar;Alessandro Bisello;Gal Bitan;Michael Rosenblatt

Frequent Co-Authors

Thomas Schrader
Thomas Schrader University of Duisburg-Essen
Frank-Gerrit Klärner
Frank-Gerrit Klärner University of Duisburg-Essen
David B. Teplow
David B. Teplow University of California, Los Angeles
Michael T. Bowers
Michael T. Bowers University of California, Santa Barbara
Joseph A. Loo
Joseph A. Loo University of California, Los Angeles
Claudio Grassi
Claudio Grassi Catholic University of the Sacred Heart
Jan Münch
Jan Münch University of Ulm
Horacio Kaufmann
Horacio Kaufmann New York University

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