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Frank-Gerrit Klärner

Frank-Gerrit Klärner

D-Index & Metrics

Chemistry

D-Index
41
Citations
7037
World Ranking
17722
National Ranking
1283

Overview

Frank-Gerrit Klärner is affiliated with the University of Duisburg-Essen in Germany. Their research activity spans multiple areas within medicine and the biological sciences, with a particular focus on neurological disorders and molecular mechanisms relevant to disease.

The main fields of study pursued by Klärner include Medicine and Biochemistry, Genetics and Molecular Biology. Within these broad categories, key subfields addressed are Physiology, Neurology, Molecular Biology, Cell Biology, and Pharmacology.

The topics most frequently covered in Klärner's work are:

  • Alzheimer's disease research and treatments
  • Parkinson's Disease Mechanisms and Treatments
  • Cellular transport and secretion
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Lysosomal Storage Disorders Research
  • Cholinesterase and Neurodegenerative Diseases
  • Computational Drug Discovery Methods

Klärner has published in several scientific journals, with repeated contributions to:

  • Molecular Therapy
  • Alzheimer's Research & Therapy
  • ACS Chemical Neuroscience
  • Nature Communications
  • Cell chemical biology

Frequent co-authors collaborating with Klärner include Thomas Schräder, Gal Bitan, Ibrar Siddique, Zizheng Li, and Ian Hurst.

Selected recent papers authored or co-authored by Klärner are:

  • CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease, 2020, published in Nature Communications
  • The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease, 2020, Molecular Therapy
  • The molecular tweezer CLR01 improves behavioral deficits and reduces tau pathology in P301S-tau transgenic mice, 2021, Alzheimer's Research & Therapy
  • Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers, 2021, Cell chemical biology
  • Molecular Tweezers: Supramolecular Hosts with Broad-Spectrum Biological Applications, 2022, Pharmacological Reviews

Best Publications

  • Molecular tweezers and clips as synthetic receptors. Molecular recognition and dynamics in receptor-substrate complexes.

    Frank-Gerrit Klärner;Björn Kahlert

  • Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins

    Sharmistha Sinha;Dahabada H. J. Lopes;Zhenming Du;Eric S. Pang

  • A molecular tweezer for lysine and arginine.

    Michael Fokkens;Thomas Schrader;Frank-Gerrit Klärner

  • Aromatic interactions by molecular tweezers and clips in chemical and biological systems.

    Frank-Gerrit Klärner;Thomas Schrader

  • Molecular tweezers modulate 14-3-3 protein-protein interactions

    David Bier;Rolf Rose;Kenny Bravo-Rodriguez;Maria Bartel

  • Molecular Clip and Tweezer Introduce New Mechanisms of Enzyme Inhibition

    Peter Talbiersky;Frank Bastkowski;Frank-Gerrit Klärner;Thomas Schrader

  • A Novel "Molecular Tweezer" Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo

    Shubhangi Prabhudesai;Sharmistha Sinha;Aida Attar;Aswani Kotagiri

  • Molecular Tweezers for Lysine and Arginine – Powerful Inhibitors of Pathologic Protein Aggregation

    Thomas Schrader;Gal Bitan;Frank-Gerrit Klärner

  • Structure and Dynamics of the Host–Guest Complex of a Molecular Tweezer: Coupling Synthesis, Solid-State NMR, and Quantum-Chemical Calculations

    Steven P. Brown;Torsten Schaller;Uta P. Seelbach;Felix Koziol

  • Molecular Tweezer and Clip in Aqueous Solution: Unexpected Self-Assembly, Powerful Host−Guest Complex Formation, Quantum Chemical 1H NMR Shift Calculation

    Frank-Gerrit Klärner;Björn Kahlert;Anke Nellesen;Jan Zienau

  • Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.

    Sharmistha Sinha;Zhenming Du;Panchanan Maiti;Frank-Gerrit Klärner

  • About the Antiaromaticity of Planar Cyclooctatetraene I thank Jens Panitzky for the additional DFT calculations, and Professor Jay Siegel, La Jolla, CA, and Professor Otto Ermer, Cologne, for helpful comments.

    Frank-Gerrit Klärner

  • Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.

    Srabasti Acharya;Brian M. Safaie;Piriya Wongkongkathep;Magdalena I. Ivanova

  • Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.

    Aida Attar;Cristian Ripoli;Elisa Riccardi;Panchanan Maiti

  • Modeling the Supramolecular Properties of Aliphatic-Aromatic Hydrocarbons with Convex-Concave Topology.

    Markus Kamieth;Frank-Gerrit Klärner;François Diederich

  • Molecular tweezers as synthetic receptors: molecular recognition of electron-deficient aromatic and aliphatic substrates.

    Frank-Gerrit Klärner;Ulrich Burkert;Markus Kamieth;Roland Boese

  • Modeling of Supramolecular Properties of Molecular Tweezers, Clips, and Bowls

    Frank-Gerrit Klärner;Jens Panitzky;Dorin Preda;Lawrence T. Scott

  • The Effect of Pressure on Organic Reactions

    Frank-Gerrit Klärner;Frank Wurche

  • Molecular Tweezers as Synthetic Receptors in Host—Guest Chemistry: Inclusion of Cyclohexane and Self‐Assembly of Aliphatic Side Chains

    Frank-Gerrit Klärner;Johannes Benkhoff;Roland Boese;Ulrich Burkert

  • Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03.

    Xueyun Zheng;Deyu Liu;Frank-Gerrit Klärner;Thomas Schrader

  • Inversionsbarrieren Ortho,ortho′‐verbrückter Biphenyle

    Klaus Müllen;Willi Heinz;Frank-Gerrit Klärner;Wolfgang R. Roth

  • Synthesis and supramolecular structures of molecular clips

    Frank-Gerrit Klärner;Jens Panitzky;Dieter Bläser;Roland Boese

  • High pressure chemistry : synthetic, mechanistic, and supercritical applications

    Rudi van Eldik;Frank-Gerrit Klärner

  • Molecular Tweezer and Clip in Aqueous Solution: Unexpected Self-Assembly, Powerful Host-Guest Complex Formation, Quantum Chemical 1H NMR Shift Calculation [J. Am. Chem. Soc 2006, 128,4831-4841]

    Frank-Gerrit Klärner;Björn Kahlert;Anke Nellesen;Jan Zienau

Frequent Co-Authors

Thomas Schrader
Thomas Schrader University of Duisburg-Essen
Gal Bitan
Gal Bitan University of California, Los Angeles
Roland Boese
Roland Boese University of Duisburg-Essen
Fritz Vögtle
Fritz Vögtle University of Bonn
Paola Ceroni
Paola Ceroni University of Bologna
Dieter Bläser
Dieter Bläser University of Duisburg-Essen
Christian Ochsenfeld
Christian Ochsenfeld Ludwig-Maximilians-Universität München
Joseph A. Loo
Joseph A. Loo University of California, Los Angeles
Vincenzo Balzani
Vincenzo Balzani University of Bologna
Waldemar Adam
Waldemar Adam University of Würzburg

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