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Microbiology

D-Index
64
Citations
13464
World Ranking
2629
National Ranking
1060

Overview

Christoph Rader is affiliated with the Scripps Research Institute in the United States. Their research spans fields including medicine as well as biochemistry, genetics, and molecular biology. Within these domains, their work focuses on molecular biology, radiology, nuclear medicine and imaging, oncology, immunology, and genetics.

Their notable research topics include monoclonal and polyclonal antibodies research, CAR-T cell therapy research, glycosylation and glycoproteins research, chronic lymphocytic leukemia research, advanced biosensing techniques and applications, HER2/EGFR in cancer research, and galectins and cancer biology.

Frequent publication venues for Christoph Rader's work include:

  • Cold Spring Harbor Protocols
  • Blood
  • Nature Communications
  • Oncogene
  • Cancer Research

They have collaborated frequently with researchers such as Haiyong Peng, Jessica Nunes, Natarajan Muthusamy, Dobeen Hwang, and Ajeeth Adhikari.

Among their recent published papers are:

  • SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity (2020, Nature Communications)
  • Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade (2020, Cancer Cell)
  • Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2 (2021, PLoS Pathogens)
  • Antibody-based cancer therapy (2021, Oncogene)
  • Generation and validation of structurally defined antibody-siRNA conjugates (2020, Nucleic Acids Research)

Best Publications

  • SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity

    Lizhou Zhang;Cody B. Jackson;Huihui Mou;Amrita Ojha

  • Receptor Affinity and Extracellular Domain Modifications Affect Tumor Recognition by ROR1-Specific Chimeric Antigen Receptor T Cells

    Michael Hudecek;Maria Teresa Lupo-Stanghellini;Paula L. Kosasih;Daniel Sommermeyer

  • The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for In Vivo Antitumor Activity

    Michael Hudecek;Michael Hudecek;Daniel Sommermeyer;Paula L. Kosasih;Anne Silva-Benedict;Anne Silva-Benedict

  • The B-cell tumor-associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor.

    Michael Hudecek;Michael Hudecek;Thomas M. Schmitt;Sivasubramanian Baskar;Maria Teresa Lupo-Stanghellini

  • Phage display of combinatorial antibody libraries.

    Christoph Rader;Carlos F Barbas

  • A phage display approach for rapid antibody humanization: Designed combinatorial V gene libraries

    Christoph Rader;David A. Cheresh;Carlos F. Barbas

  • Unique cell surface expression of receptor tyrosine kinase ROR1 in human B-cell chronic lymphocytic leukemia.

    Sivasubramanian Baskar;Ka Yin Kwong;Thomas Hofer;Jessica M Levy

  • Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.

    Shivani Srivastava;Scott N. Furlan;Scott N. Furlan;Carla A. Jaeger-Ruckstuhl;Megha Sarvothama

  • Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting.

    Shivani Srivastava;Alexander I. Salter;Denny Liggitt;Sushma Yechan-Gunja

  • The Nogo-66 Receptor Homolog NgR2 Is a Sialic Acid-Dependent Receptor Selective for Myelin-Associated Glycoprotein

    Karthik Venkatesh;Onanong Chivatakarn;Hakjoo Lee;Pushkar S. Joshi

  • A novel adoptive transfer model of chronic lymphocytic leukemia suggests a key role for T lymphocytes in the disease

    Davide Bagnara;Matthew S. Kaufman;Matthew S. Kaufman;Matthew S. Kaufman;Carlo Calissano;Sonia Marsilio

  • Methods for the generation of chicken monoclonal antibody fragments by phage display.

    Jennifer Andris-Widhopf;Christoph Rader;Peter Steinberger;Roberta Fuller

  • Contactin-2/TAG-1-directed autoimmunity is identified in multiple sclerosis patients and mediates gray matter pathology in animals

    Tobias Derfuss;Khyati Parikh;Sviataslau Velhin;Magdalena Braun

  • Rabbit Immune Repertoires as Sources for Therapeutic Monoclonal Antibodies: The Impact of Kappa Allotype-correlated Variation in Cysteine Content on Antibody Libraries Selected by Phage Display

    Mikhail Popkov;Rose G. Mage;Cornelius B. Alexander;Sujatha Thundivalappil

  • Clinical development of a poly(2-oxazoline) (POZ) polymer therapeutic for the treatment of Parkinson’s disease – Proof of concept of POZ as a versatile polymer platform for drug development in multiple therapeutic indications

    Randall W. Moreadith;Tacey X. Viegas;Michael D. Bentley;J. Milton Harris

  • Safety of Targeting ROR1 in Primates with Chimeric Antigen Receptor–Modified T Cells

    Carolina Berger;Carolina Berger;Daniel Sommermeyer;Michael Hudecek;Michael Berger

  • The rabbit antibody repertoire as a novel source for the generation of therapeutic human antibodies

    Christoph Rader;Gerd Ritter;Sheila Nathan;Marikka Elia

  • From rabbit antibody repertoires to rabbit monoclonal antibodies.

    Justus Weber;Haiyong Peng;Christoph Rader

  • Multiple event activation of a generic prodrug trigger by antibody catalysis

    Doron Shabat;Christoph Rader;Benjamin List;Richard A. Lerner

  • Implications of the HIV-1 Rev dimer structure at 3.2 Å resolution for multimeric binding to the Rev response element

    Michael A. DiMattia;Norman R. Watts;Stephen J. Stahl;Christoph Rader

  • Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B Cells through a PI3-kinase dependent pathway

    Rosa Lapalombella;Leslie Andritsos;Qing Liu;Sarah E. May

Frequent Co-Authors

Carlos F. Barbas
Carlos F. Barbas Scripps Research Institute
Stanley R. Riddell
Stanley R. Riddell University of Washington
Terrence R. Burke
Terrence R. Burke National Institutes of Health
Peter Sonderegger
Peter Sonderegger University of Zurich
John C. Byrd
John C. Byrd University of Pittsburgh Cancer Institute
Richard A. Lerner
Richard A. Lerner Scripps Research Institute
William R. Roush
William R. Roush Scripps Research Institute
David G. Maloney
David G. Maloney Fred Hutchinson Cancer Research Center
Ben Shen
Ben Shen Scripps Research Institute
Michael C. Jensen
Michael C. Jensen Seattle Children's Hospital

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