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Biology and Biochemistry

D-Index
54
Citations
11701
World Ranking
15537
National Ranking
6480

Overview

Benjamin Weiss is a researcher affiliated with Drexel University in the United States. Their work primarily focuses on biochemistry, genetics, and molecular biology, with a concentration on molecular biology as a key subfield. Weiss's research intersects several areas including RNA and protein synthesis mechanisms, RNA modifications and cancer, RNA research and splicing, PI3K/AKT/mTOR signaling in cancer, polyamine metabolism and applications, CRISPR and genetic engineering, and genetic neurodegenerative diseases.

Weiss has contributed to multiple recent publications, among which are:

  • Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A (2021, Cell Reports)
  • eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome (2021, Nucleic Acids Research)
  • Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation (2022, Proceedings of the National Academy of Sciences)
  • Not1 and Not4 inversely determine mRNA solubility that sets the dynamics of co-translational events (2023, Genome Biology)
  • Topological characteristic factors and nilsystems (2023, Journal of the European Mathematical Society)

Frequent collaborators include George E. Allen, Olesya O. Panasenko, Zoltán Villányi, Marina Zagatti, and Christine Polte. Weiss has published multiple papers in venues such as bioRxiv (Cold Spring Harbor Laboratory), Cell Reports, arXiv (Cornell University), Nucleic Acids Research, and Proceedings of the National Academy of Sciences.

Their scholarly work exhibits a strong integration of molecular biology techniques and computational approaches, including contributions to computational theory and mathematics alongside molecular and cellular neuroscience. Additionally, Weiss's research encompasses mathematical physics and finance topics.

The scientist's work is characterized by investigations into the molecular mechanisms regulating RNA biology and protein synthesis, as well as their implications on disease models including cancer and neurodegenerative disorders. Their studies also address regulatory complexes affecting cellular stress responses and protein translation.

Best Publications

  • A simple, sensitive method for the assay of adenyl cyclase.

    Gopal Krishna;Benjamin Weiss;Bernard B. Brodie

  • Binding of trifluoperazine to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

    Robert M. Levin;Benjamin Weiss

  • Mechanism by Which Psychotropic Drugs Inhibit Adenosine Cyclic 3',5'-Monophosphate Phosphodiesterase of Brain

    Robert M. Levin;Benjamin Weiss

  • Selective binding of antipsychotics and other psychoactive agents to the calcium-dependent activator of cyclic nucleotide phosphodiesterase.

    R M Levin;B Weiss

  • Mechanism for selectively inhibiting the activation of cyclic nucleotide phosphodiesterase and adenylate cyclase by antipsychotic agents.

    Weiss B;Levin Rm

  • PHARMACOLOGICAL REGULATION OF CALMODULIN

    Benjamin Weiss;Walter Prozialeck;Mauro Cimino;Mary Sellinger Barnette

  • Interaction of drugs with calmodulin. Biochemical, pharmacological and clinical implications.

    Benjamin Weiss;Walter C. Prozialeck;Thomas L. Wallace

  • Inhibition of calmodulin by phenothiazines and related drugs: structure-activity relationships.

    W C Prozialeck;B Weiss

  • beta-Adrenergic receptors in aged rat brain: reduced number and capacity of pineal gland to develop supersensitivity.

    Louise H. Greenberg;Benjamin Weiss

  • Specificity of the binding of trifluoperazine to the calcium-dependent activator of phosphodiesterase and to a series of other calcium-binding proteins.

    Robert M. Levin;Benjamin Weiss

  • Separation of multiple molecular forms of cyclic adenosine-3',5'-monophosphate phosphodiesterase in rat cerebellum by polyacrylamide gel electrophoresis.

    Petko Uzunov;Benjamin Weiss

  • Dipeptidyl Peptidase‐4 Inhibitors Administered in Combination With Metformin Result in an Additive Increase in the Plasma Concentration of Active GLP‐1

    E M Migoya;R Bergeron;J L Miller;R N K Snyder

  • SELECTIVE STIMULATION OF ADENYL CYCLASE OF RAT PINEAL GLAND BY PHARMACOLOGICALLY ACTIVE CATECHOLAMINES

    Benjamin Weiss;E. Costa

  • Regional and subcellular distribution of adenyl cyclase and 3',5'-cyclic nucleotide phosphodiesterase in brain and pineal gland☆☆☆

    Benjamin Weiss;E. Costa

  • Continuous treatment with the D2 dopamine receptor agonist quinpirole decreases D2 dopamine receptors, D2 dopamine receptor messenger RNA and proenkephalin messenger RNA, and increases mu opioid receptors in mouse striatum

    J.F. Chen;V.J. Aloyo;B. Weiss

  • Adenyl Cyclase Activity in Rat Pineal Gland: Effects of Chronic Denervation and Norepinephrine

    Benjamin Weiss;Erminio Costa

  • Selective Cyclic Nucleotide Phosphodiesterase Inhibitors as Potential Therapeutic Agents

    B Weiss;W N Hait

  • Antisense RNA gene therapy for studying and modulating biological processes.

    B. Weiss;G. Davidkova;L.-W. Zhou

  • Selective Alteration of the Activity of the Multiple Forms of Adenosine 3', 5'-Monophosphate Phosphodiesterase of Rat Cerebrum

    Benjamin Weiss;Richard Fertel;Robert Figlin;Petko Uzunov

  • Rapid microassay of adenosine 3′,5′-monophosphate phosphodiesterase activity☆

    Benjamin Weiss;Richard Lehne;Samuel Strada

Frequent Co-Authors

Abel Lajtha
Abel Lajtha New York University
Miklós Palkovits
Miklós Palkovits Semmelweis University
Albert M. Kligman
Albert M. Kligman University of Pennsylvania
Eugene M. Johnson
Eugene M. Johnson Washington University in St. Louis
Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Grace Y. Sun
Grace Y. Sun University of Missouri
Norton H. Neff
Norton H. Neff The Ohio State University
Rick C.S. Lin
Rick C.S. Lin University of Mississippi Medical Center
Maria Hadjiconstantinou
Maria Hadjiconstantinou The Ohio State University
David C. Klein
David C. Klein National Institutes of Health

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