D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 88 Citations 29,379 336 World Ranking 8350 National Ranking 4476

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Enzyme
  • Internal medicine

David C. Klein mainly focuses on Internal medicine, Endocrinology, Melatonin, Pineal gland and AANAT. Serotonin, Circadian rhythm, Pinealocyte, Stimulation and Aralkylamine N-acetyltransferase are the primary areas of interest in his Internal medicine study. His research integrates issues of Rhythm and Adrenergic in his study of Endocrinology.

The concepts of his Melatonin study are interwoven with issues in Period, Hormone, Anterior pituitary, Luteinizing hormone and Circadian clock. His biological study spans a wide range of topics, including In situ hybridization, Optic tract, Gene, Visual system and Retinohypothalamic tract. His AANAT research integrates issues from Arylalkylamine, Molecular biology and Binding site.

His most cited work include:

  • Suprachiasmatic nucleus : the mind's clock (1252 citations)
  • Prostaglandins: Stimulation of Bone Resorption in Tissue Culture (858 citations)
  • Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N-Acetyltransferase (684 citations)

What are the main themes of his work throughout his whole career to date?

The scientist’s investigation covers issues in Internal medicine, Endocrinology, Pineal gland, Melatonin and Pinealocyte. As a part of the same scientific study, David C. Klein usually deals with the Endocrinology, concentrating on Retina and frequently concerns with Retinal. His research investigates the connection between Pineal gland and topics such as Gene expression that intersect with issues in Molecular biology.

His research in Melatonin intersects with topics in Pituitary gland, Darkness, Messenger RNA and Enzyme. David C. Klein has included themes like Protein kinase A, Norepinephrine, Agonist, Protein kinase C and PDE10A in his Pinealocyte study. The study incorporates disciplines such as Arylalkylamine and Proteolysis in addition to AANAT.

He most often published in these fields:

  • Internal medicine (65.21%)
  • Endocrinology (65.21%)
  • Pineal gland (44.66%)

What were the highlights of his more recent work (between 2003-2020)?

  • Pineal gland (44.66%)
  • Internal medicine (65.21%)
  • Endocrinology (65.21%)

In recent papers he was focusing on the following fields of study:

His primary scientific interests are in Pineal gland, Internal medicine, Endocrinology, AANAT and Melatonin. His Pineal gland study introduces a deeper knowledge of Circadian rhythm. As part of one scientific family, David C. Klein deals mainly with the area of Internal medicine, narrowing it down to issues related to the Retina, and often Retinal.

His Endocrinology research includes themes of Phosphodiesterase and PAX6. His AANAT research incorporates elements of Arylalkylamine, Tryptamine and Molecular biology. His Melatonin research is multidisciplinary, incorporating perspectives in Adenosine, Light effects on circadian rhythm and Darkness.

Between 2003 and 2020, his most popular works were:

  • Arylalkylamine N-Acetyltransferase: “the Timezyme” (301 citations)
  • Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina (273 citations)
  • Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205 (165 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Internal medicine

David C. Klein spends much of his time researching Pineal gland, Melatonin, AANAT, Endocrinology and Internal medicine. His Pineal gland research focuses on Genetics and how it connects with Computational biology. His Melatonin research is multidisciplinary, relying on both Circadian clock and Gene.

In his work, Vertebrate is strongly intertwined with Arylalkylamine, which is a subfield of AANAT. His studies deal with areas such as Retina and Transcriptome as well as Endocrinology. His studies in Internal medicine integrate themes in fields like Gene expression and In situ hybridization.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Suprachiasmatic nucleus : the mind's clock

D. C. Klein;Robert Y. Moore;Steven M. Reppert.
(1991)

2020 Citations

Prostaglandins: Stimulation of Bone Resorption in Tissue Culture

David C. Klein;Lawrence G. Raisz.
Endocrinology (1970)

1348 Citations

Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N-Acetyltransferase

David C. Klein;Joan L. Weller.
Science (1970)

1077 Citations

Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity

Robert Y. Moore;Robert Y. Moore;David C. Klein;David C. Klein.
Brain Research (1974)

989 Citations

Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus.

David C. Klein;David C. Klein;Robert Y. Moore;Robert Y. Moore.
Brain Research (1979)

810 Citations

The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland.

Klein Dc;Coon Sl;Roseboom Ph;Weller Jl.
Recent Progress in Hormone Research (1997)

630 Citations

Rapid Light-Induced Decrease in Pineal Serotonin N-Acetyltransferase Activity

David C. Klein;Joan L. Weller.
Science (1972)

514 Citations

GCN5-RELATED N-ACETYLTRANSFERASES: A Structural Overview

Fred Dyda;David C. Klein;Alison Burgess Hickman.
Annual Review of Biophysics and Biomolecular Structure (2000)

501 Citations

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

David Sugden;Jiri Vanecek;David C. Klein;Thomas P. Thomas.
Nature (1985)

477 Citations

Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex: A Role for Scaffolding in Enzyme Regulation

Tomas Obsil;Rodolfo Ghirlando;David C Klein;Surajit Ganguly.
Cell (2001)

461 Citations

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