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Medicine

D-Index
96
Citations
33968
World Ranking
9662
National Ranking
4974

Overview

David C. Klein is a researcher affiliated with the National Institutes of Health in the United States. Their work primarily focuses on biochemical and medical topics, with significant contributions in molecular biology, neurology, physiology, biomedical engineering, and pathology and forensic medicine.

The main fields of study covered by their publications include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broader fields, the subfields of molecular biology, neurology, physiology, biomedical engineering, and pathology and forensic medicine are prominently featured in their research output.

David C. Klein's research centers on several main topics, including:

  • Single-cell and spatial transcriptomics
  • Neuroinflammation and neurodegeneration mechanisms
  • Retinal development and disorders
  • Spinal cord injury research
  • Scoliosis diagnosis and treatment
  • Growth hormone and insulin-like growth factors
  • Adipose tissue and metabolism

Their recent publications reflect a focus on molecular and cellular processes related to the pineal gland and retina, as well as methodological approaches. Notable papers include:

  • "Resource: A multi-species multi-timepoint transcriptome database and webpage for the pineal gland and retina," 2020, Journal of Pineal Research
  • "Surgical Techniques and Nuances for Superior Cervical Ganglionectomy and Decentralization in Rats," 2022, Methods in Molecular Biology
  • "Two-Dimensional Thin Layer Chromatography of Melatonin and Related Compounds," 2022, Methods in Molecular Biology
  • "The Pineal Transcriptome Webpage," 2022, Methods in Molecular Biology
  • "Preparation of Single Pineal Cells," 2022, Methods in Molecular Biology

The frequent publication venues for Klein's work are:

  • Methods in Molecular Biology
  • Journal of Pineal Research
  • Endocrinología Diabetes y Nutrición
  • The Journal of Law Medicine & Ethics

Co-authorship collaborations are an element of their research activity, with frequent collaborators including:

  • Steven L. Coon
  • Eric Terry Wang Wei-Chiao Chang
  • Cong Fu
  • Shahar Alon
  • Marjan Bozinoski

Best Publications

  • Suprachiasmatic nucleus : the mind's clock

    D. C. Klein;Robert Y. Moore;Steven M. Reppert

  • Prostaglandins: Stimulation of Bone Resorption in Tissue Culture

    David C. Klein;Lawrence G. Raisz

  • Indole Metabolism in the Pineal Gland: A Circadian Rhythm in N-Acetyltransferase

    David C. Klein;Joan L. Weller

  • Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity

    Robert Y. Moore;Robert Y. Moore;David C. Klein;David C. Klein

  • Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus.

    David C. Klein;David C. Klein;Robert Y. Moore;Robert Y. Moore

  • The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland.

    Klein Dc;Coon Sl;Roseboom Ph;Weller Jl

  • GCN5-RELATED N-ACETYLTRANSFERASES: A Structural Overview

    Fred Dyda;David C. Klein;Alison Burgess Hickman

  • Rapid Light-Induced Decrease in Pineal Serotonin N-Acetyltransferase Activity

    David C. Klein;Joan L. Weller

  • Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

    David Sugden;Jiri Vanecek;David C. Klein;Thomas P. Thomas

  • Melatonin Production: Proteasomal Proteolysis in Serotonin N-acetyltransferase Regulation

    Jonathan A. Gastel;Patrick H. Roseboom;Peter A. Rinaldi;Joan L. Weller

  • Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina

    P. Michael Iuvone;Gianluca Tosini;Nikita Pozdeyev;Rashidul Haque

  • Pineal Serotonin N-Acetyltransferase: Expression Cloning and Molecular Analysis

    Steven L. Coon;Patrick H. Roseboom;Ruben Baler;Joan L. Weller

  • Natural melatonin `knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase

    Patrick H Roseboom;M.A.Aryan Namboodiri;Drazen B Zimonjic;Nicholas C Popescu

  • Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland.

    Patrick H. Roseboom;Steven L. Coon;Ruben Baler;Susan K. McCUNE

  • Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme A N-acetyltransferase activity.

    David C. Klein;Joan L. Weller;Robert Y. Moore

  • Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation.

    Surajit Ganguly;Steven L. Coon;David C. Klein

  • Postsynaptic alpha-adrenergic receptors potentiate the beta-adrenergic stimulation of pineal serotonin N-acetyltransferase

    David C. Klein;David Sugden;Joan L. Weller

  • Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic→ spinal cord circuit in the melatonin rhythm generating system

    D.C. Klein;R. Smoot;J.L. Weller;S. Higa

  • Melatonin Synthesis: Adenosine 3',5'-Monophosphate and Norepinephrine Stimulate N-Acetyltransferase

    David C. Klein;Gerald R. Berg;Joan Weller

  • Atypical synergistic α1- and β-adrenergic regulation of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in rat pinealocytes

    Jiri Vanecek;David Sugden;Joan Weller;David C. Klein

Frequent Co-Authors

Morten Møller
Morten Møller University of Copenhagen
Fred Dyda
Fred Dyda National Institutes of Health
Rashidul Haque
Rashidul Haque International Centre for Diarrhoeal Disease Research
P. Michael Iuvone
P. Michael Iuvone Emory University
Steven M. Reppert
Steven M. Reppert University of Massachusetts Chan Medical School
Kenneth L. Kirk
Kenneth L. Kirk National Institutes of Health
Valentín Ceña
Valentín Ceña University of Castilla-La Mancha
Igal Gery
Igal Gery National Institutes of Health
Gilles Boeuf
Gilles Boeuf Centre national de la recherche scientifique, CNRS
Philip A. Cole
Philip A. Cole Brigham and Women's Hospital

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