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Biology and Biochemistry

D-Index
119
Citations
52150
World Ranking
672
National Ranking
426

Medicine

D-Index
121
Citations
53364
World Ranking
3612
National Ranking
1993

Research.com Recognitions

  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Philip A. Cole is affiliated with Brigham and Women's Hospital in the United States. Their research spans extensively across the fields of biochemistry, genetics, and molecular biology, with a particular focus on molecular biology, oncology, cell biology, immunology, and genetics. The predominant area of study involves biochemical pathways and mechanisms related to protein modification and degradation.

Their recent scholarly contributions include the following publications:

  • The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway (2021, Science Advances)
  • The Chemical Biology of Reversible Lysine Post-translational Modifications (2020, Cell Chemical Biology)
  • Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex (2020, Cell Reports)
  • Nuclear GTPSCS functions as a lactyl-CoA synthetase to promote histone lactylation and gliomagenesis (2024, Cell Metabolism)
  • Combined Targeting of the BRD4-NUT-p300 Axis in NUT Midline Carcinoma by Dual Selective Bromodomain Inhibitor, NEO2734 (2020, Molecular Cancer Therapeutics)

Frequent co-authors involved in collaborative research with Philip A. Cole include:

  • Hanjie Jiang
  • Kwangwoon Lee
  • Zhipeng A. Wang
  • Samuel D. Whedon
  • Rhoda M. Alani

The primary publication venues where this scientist has disseminated findings are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the American Chemical Society
  • Journal of Biological Chemistry
  • Journal of Investigative Dermatology
  • eLife

The main topics of their research reflect a concentration on cellular regulation and protein pathways, including:

  • Ubiquitin and proteasome pathways
  • Protein degradation and inhibitors
  • Histone deacetylase inhibitors research
  • Genomics and chromatin dynamics
  • Epigenetics and DNA methylation
  • PI3K/AKT/mTOR signaling in cancer
  • Peptidase inhibition and analysis

Philip A. Cole was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2013. The fellowship acknowledges contributions to scientific advancement, although no specific citation details were provided.

Best Publications

  • Histone demethylation mediated by the nuclear amine oxidase homolog lsd1

    Yang Shi;Yujiang Shi

  • An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor

    Xuewu Zhang;Jodi Gureasko;Kui Shen;Philip A. Cole

  • Epidemiology and etiology of Parkinson’s disease: a review of the evidence

    Karin Wirdefeldt;Hans-Olov Adami;Hans-Olov Adami;Philip Cole;Dimitrios Trichopoulos

  • Expressed protein ligation: A general method for protein engineering

    Tom W. Muir;Dolan Sondhi;Philip A. Cole

  • Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

    Sang Won Min;Seo Hyun Cho;Yungui Zhou;Sebastian Schroeder

  • Etiology of human breast cancer: a review.

    Brian MacMahon;Philip Cole;James Brown

  • Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours.

    Loren M. Lasko;Clarissa G. Jakob;Rohinton P. Edalji;Wei Qiu

  • Menopause and breast cancer risk.

    Dimitrios Trichopoulos;Brian MacMahon;Philip Cole

  • Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor.

    Erin M. Bowers;Gai Yan;Chandrani Mukherjee;Andrew Orry

  • Cigarette smoking and urinary estrogens.

    Brian MacMahon;Dimitrios Trichopoulos;Philip Cole;James Brown

  • Incidence rates of salivary gland tumors : results from a population-based study

    John A. Pinkston;Philip Cole

  • The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

    Xin Liu;Ling Wang;Kehao Zhao;Kehao Zhao;Paul R. Thompson;Paul R. Thompson

  • Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

    Prashant Mali;Bin Kuan Chou;Jonathan Yen;Zhaohui Ye

  • Regulation of the p300 HAT domain via a novel activation loop

    Paul R Thompson;Paul R Thompson;Dongxia Wang;Ling Wang;Marcella Fulco

  • Protein lysine acetylation by p300/CBP.

    Beverley M. Dancy;Philip A. Cole

  • Basic Issues in Population Screening for Cancer

    Philip Cole;Alan S. Morrison

  • The non‐Hodgkin lymphomas: A review of the epidemiologic literature

    Dominik D. Alexander;Pamela J. Mink;Hans-Olov Adami;Hans-Olov Adami;Ellen T. Chang

  • HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF.

    Ontario D. Lau;Ontario D. Lau;Tapas K. Kundu;Raymond E. Soccio;Slimane Ait-Si-Ali

  • DNA Damage-Dependent Acetylation of p73 Dictates the Selective Activation of Apoptotic Target Genes

    Antonio Costanzo;Antonio Costanzo;Paola Merlo;Natalia Pediconi;Marcella Fulco

  • Erratum to Acetylation of tau inhibits its degradation and contributes to tauopathy

    Sang Won Min;Seo Hyun Cho;Yungui Zhou;Sebastian Schroeder

Frequent Co-Authors

Brian MacMahon
Brian MacMahon Harvard University
Ronen Marmorstein
Ronen Marmorstein University of Pennsylvania
Dimitrios Trichopoulos
Dimitrios Trichopoulos Harvard University
Hans-Olov Adami
Hans-Olov Adami Karolinska Institute
Albena T. Dinkova-Kostova
Albena T. Dinkova-Kostova University of Dundee
Keykavous Parang
Keykavous Parang Chapman University
Wayne W. Hancock
Wayne W. Hancock University of Pennsylvania
Daniel J. Leahy
Daniel J. Leahy Johns Hopkins University School of Medicine
L. Mario Amzel
L. Mario Amzel Johns Hopkins University School of Medicine
Jef D. Boeke
Jef D. Boeke New York University

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