Daniel J. Leahy mostly deals with Protein structure, Biochemistry, Cell biology, Binding site and ErbB. His Protein structure research includes elements of Epidermal growth factor, Transmembrane protein, Signal transduction, Frizzled and LRP6. His research integrates issues of Biophysics and Sequence alignment in his study of Biochemistry.
His work carried out in the field of Cell biology brings together such families of science as Polyethylenimine and Mammalian cell. The Binding site study combines topics in areas such as Integrin and Crystal structure. His research investigates the connection with ErbB and areas like Receptor tyrosine kinase which intersect with concerns in ErbB Receptors.
His scientific interests lie mostly in Cell biology, Biochemistry, Receptor, Epidermal growth factor receptor and Protein structure. His Cell biology research includes themes of Integral membrane protein, Membrane protein and Molecular biology. His Receptor research focuses on Extracellular and how it connects with Crystallography, CD8 and Monoclonal antibody.
The study incorporates disciplines such as Cancer research, Growth factor receptor, Immunology and Phosphorylation in addition to Epidermal growth factor receptor. Daniel J. Leahy interconnects Frizzled and Sequence alignment in the investigation of issues within Protein structure. His ErbB study integrates concerns from other disciplines, such as Epidermal growth factor, ErbB Receptors, Antibody and ERBB4.
His primary scientific interests are in Cell biology, Receptor, Extracellular, Biochemistry and Receptor tyrosine kinase. His Cell biology research incorporates themes from Vesicle, Membrane, Membrane biophysics, Membrane protein and Cell surface receptor. His Epidermal growth factor receptor and Ligand study in the realm of Receptor interacts with subjects such as Immunoglobulin Fc Fragments.
His work on Protein structure, Methylation, Hydrolase and Lysine as part of general Biochemistry study is frequently linked to Acetylation, bridging the gap between disciplines. While the research belongs to areas of Protein structure, Daniel J. Leahy spends his time largely on the problem of Receptor complex, intersecting his research to questions surrounding Hedgehog signaling pathway, Hedgehog and Patched. The concepts of his Receptor tyrosine kinase study are interwoven with issues in Protein kinase B, Growth factor receptor, MAPK/ERK pathway and Effector.
His scientific interests lie mostly in Cell biology, Integral membrane protein, Neuroscience, Biochemistry and Yellow fluorescent protein. His study ties his expertise on Molecular biology together with the subject of Cell biology. His biological study spans a wide range of topics, including Function and Hedgehog, Signal transduction, Patched, Hedgehog signaling pathway.
His Neuroscience study incorporates themes from Consensus sequence and Binding site. He merges Biochemistry with Acetylation in his research. His Yellow fluorescent protein research spans across into areas like Vesicle, Biophysics, Membrane biophysics, Membrane and Peripheral membrane protein.
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Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab
Hyun Soo Cho;Karen Mason;Kasra X. Ramyar;Ann Marie Stanley.
An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors
Antony W. Burgess;Hyun Soo Cho;Hyun Soo Cho;Charles Eigenbrot;Kathryn M. Ferguson.
Molecular Cell (2003)
Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex
Matthew C Franklin;Kendall D Carey;Felix F Vajdos;Daniel J Leahy.
Cancer Cell (2004)
EGF Activates Its Receptor by Removing Interactions that Autoinhibit Ectodomain Dimerization
Kathryn M. Ferguson;Mitchell B. Berger;Jeannine M. Mendrola;Hyun Soo Cho.
Molecular Cell (2003)
2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region
Daniel J. Leahy;Ikramuddin Aukhil;Harold P. Erickson.
Functionally significant insulin-like growth factor I receptor mutations in centenarians
Yousin Suh;Gil Atzmon;Mi Ook Cho;David Hwang.
Proceedings of the National Academy of Sciences of the United States of America (2008)
Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.
Daniel J. Leahy;Wayne A. Hendrickson;Ikramuddin Aukhil;Harold P. Erickson.
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
Charles E. Dann;Jen Chih Hsieh;Amir Rattner;Divya Sharma.
Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether
Hyun Soo Cho;Daniel J. Leahy.
Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.
Aidong Qu;Daniel J. Leahy.
Proceedings of the National Academy of Sciences of the United States of America (1995)
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