Daniel J. Leahy

Overview

Best Publications

• Structure of the extracellular region of HER2 alone and in complex with the Herceptin Fab

  Hyun Soo Cho;Karen Mason;Kasra X. Ramyar;Ann Marie Stanley

  2017
  Citations

• Insights into ErbB signaling from the structure of the ErbB2-pertuzumab complex

  Matthew C Franklin;Kendall D Carey;Felix F Vajdos;Daniel J Leahy

  1395
  Citations

• An Open-and-Shut Case? Recent Insights into the Activation of EGF/ErbB Receptors

  Antony W. Burgess;Hyun Soo Cho;Hyun Soo Cho;Charles Eigenbrot;Kathryn M. Ferguson

  1255
  Citations

• EGF Activates Its Receptor by Removing Interactions that Autoinhibit Ectodomain Dimerization

  Kathryn M. Ferguson;Mitchell B. Berger;Jeannine M. Mendrola;Hyun Soo Cho

  1089
  Citations

• 2.0 Å Crystal Structure of a Four-Domain Segment of Human Fibronectin Encompassing the RGD Loop and Synergy Region

  Daniel J. Leahy;Ikramuddin Aukhil;Harold P. Erickson

  897
  Citations

• Functionally significant insulin-like growth factor I receptor mutations in centenarians

  Yousin Suh;Gil Atzmon;Mi Ook Cho;David Hwang

  843
  Citations

• Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein.

  Daniel J. Leahy;Wayne A. Hendrickson;Ikramuddin Aukhil;Harold P. Erickson

  712
  Citations

• Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains

  Charles E. Dann;Jen Chih Hsieh;Amir Rattner;Divya Sharma

  626
  Citations

• Structure of the Extracellular Region of HER3 Reveals an Interdomain Tether

  Hyun Soo Cho;Daniel J. Leahy

  595
  Citations

• Transient Mammalian Cell Transfection with Polyethylenimine (PEI)

  Patti A. Longo;Jennifer M. Kavran;Min Sung Kim;Daniel J. Leahy

  581
  Citations

• Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin.

  Aidong Qu;Daniel J. Leahy

  428
  Citations

• Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain.

  Jeffrey C Lee;Jeffrey C Lee;Igor Vivanco;Rameen Beroukhim;Rameen Beroukhim;Julie H. Y Huang

  420
  Citations

• Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution.

  Daniel J. Leahy;Richard Axel;Richard Axel;Wayne A. Hendrickson;Wayne A. Hendrickson

  371
  Citations

• EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics.

  Daniel M. Freed;Nicholas J. Bessman;Anatoly Kiyatkin;Emanuel Salazar-Cavazos

  335
  Citations

• Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.

  Traci M.Tanaka Hall;Jeffery A. Porter;Keith E. Young;Eugene V. Koonin

  321
  Citations

• Glucose and Weight Control in Mice with a Designed Ghrelin O-Acyltransferase Inhibitor

  Brad P. Barnett;Yousang Hwang;Martin S. Taylor;Henriette Kirchner

  308
  Citations

• Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165

  Chenghua Gu;Brian J. Limberg;G. Brian Whitaker;Ben Perman

  286
  Citations

• Mutations in the TGF-β repressor SKI cause Shprintzen-Goldberg syndrome with aortic aneurysm.

  Alexander J Doyle;Alexander J Doyle;Alexander J Doyle;Jefferson J Doyle;Seneca L Bessling;Samantha Maragh;Samantha Maragh

  284
  Citations

• Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for Patched

  Naoyuki Fuse;Tapan Maiti;Baolin Wang;Jeffery A. Porter

  263
  Citations

• The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand

  Samuel Bouyain;Patti A. Longo;Shiqing Li;Kathryn M. Ferguson

  260
  Citations