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D-Index & Metrics

Biology and Biochemistry

D-Index
55
Citations
12685
World Ranking
14926
National Ranking
6248

Overview

Jia-huai Wang is affiliated with Harvard University in the United States. Their research spans multiple subfields including Molecular Biology, Immunology, Oncology, Virology, and Ecology. Wang's work notably addresses various themes within immune cell function and interaction, T-cell and B-cell immunology, CAR-T cell therapy research, HIV research and treatment, bacteriophages and microbial interactions, lipid membrane structure and behavior, and genetics, bioinformatics, and biomedical research.

The scientist has contributed to journals such as Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature, Nature Communications, Protein & Cell, Журнал структурной химии, and Science. The breadth of publication venues reflects a multidisciplinary approach across molecular and cellular biology as well as immunological studies.

Recent papers authored or co-authored by Wang include:

  • Pre-T cell receptors topologically sample self-ligands during thymocyte β-selection, 2021, Science
  • Crystal structures of influenza nucleoprotein complexed with nucleic acid provide insights into the mechanism of RNA interaction, 2021, Nucleic Acids Research
  • Dynamic HIV-1 spike motion creates vulnerability for its membrane-bound tripod to antibody attack, 2022, Nature Communications
  • Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide, 2023, Nature Communications
  • T cell receptors, mechanosensors, catch bonds and immunotherapy, 2020, Progress in Biophysics and Molecular Biology

Wang frequently collaborates with other researchers in the field. Primary co-authors include Ellis L. Reinherz, Xiaolong Li, Réka Mizsei, Kemin Tan, and Robert J. Mallis, reflecting ongoing contributions to collaborative scientific projects.

The scientist's main research topics emphasize understanding the function and interaction of immune cells, specifically focusing on T-cell and B-cell immunology and their applications in CAR-T cell therapies. Additionally, Wang's research covers HIV, addressing both viral mechanisms and immune responses. Studies on bacteriophage interactions and the behavior of lipid membranes also form part of their multidisciplinary focus.

Best Publications

  • Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

    Tsars Xiao;Junichi Takagi;Junichi Takagi;Barry S. Coller;Jia-Huai Wang

  • Atomic structure of a thermostable subdomain of HIV-1 gp41.

    Kemin Tan;Jin Huan Liu;Jia Huai Wang;Steven Shen

  • ATOMIC STRUCTURE OF A FRAGMENT OF HUMAN CD4 CONTAINING TWO IMMUNOGLOBULIN-LIKE DOMAINS

    Jiahuai Wang;Youwei Yan;Youwei Yan;Thomas P. J. Garrett;Thomas P. J. Garrett;Jinhuan Liu

  • Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

    Motomu Shimaoka;Tsan Sam Xiao;Jin Huan Liu;Yuting Yang

  • The crystal structure of a T cell receptor in complex with peptide and MHC class II

    Ellis L. Reinherz;Kemin Tan;Lei Tang;Petra Kern

  • HIV-1 Broadly Neutralizing Antibody Extracts Its Epitope from a Kinked gp41 Ectodomain Region on the Viral Membrane

    Zhen Yu J Sun;Kyoung Joon Oh;Mikyung Kim;Jessica Yu

  • 2 å crystal structure of an extracellular fragment of human CD40 ligand

    Michael Karpusas;Yen-Ming Hsu;Jia-huai Wang;Jeff Thompson

  • Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule

    Jia-huai Wang;Rob Meijers;Yi Xiong;Jin-huan Liu

  • Crystal structure of the TSP-1 type 1 repeats a novel layered fold and its biological implication

    Kemin Tan;Mark Duquette;Mark Duquette;Jin-huan Liu;Yicheng Dong

  • Structure of a Heterophilic Adhesion Complex between the Human CD2 and CD58 (LFA-3) Counterreceptors

    Jia-huai Wang;Alex Smolyar;Kemin Tan;Jin-huan Liu

  • A dimeric crystal structure for the N-terminal two domains of intercellular adhesion molecule-1

    José M. Casasnovas;Thilo Stehle;Jin-huan Liu;Jia-huai Wang

  • Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design.

    Andy Ka-Leung Ng;Hongmin Zhang;Kemin Tan;Zongli Li

  • Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime

    Dibyendu Kumar Das;Yinnian Feng;Robert J. Mallis;Xiaolong Li

  • Structural specializations of immunoglobulin superfamily members for adhesion to integrins and viruses.

    Jia-huai Wang;Timothy A. Springer

  • Structural Basis of CD8 Coreceptor Function Revealed by Crystallographic Analysis of a Murine CD8αα Ectodomain Fragment in Complex with H-2Kb

    Petra S. Kern;Mai-kun Teng;Alex Smolyar;Jin-huan Liu

  • The three-dimensional structure of integrins and their ligands, and conformational regulation of cell adhesion.

    Timothy A Springer;Jia-Huai Wang

  • Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.

    J Wang;K Lim;A Smolyar;M Teng;M Teng

  • Complex between nidogen and laminin fragments reveals a paradigmatic |[beta]|-propeller interface

    Junichi Takagi;Yuting Yang;Jin-huan Liu;Jia-huai Wang

  • Archaeal Surface Layer Proteins Contain β Propeller, PKD, and β Helix Domains and Are Related to Metazoan Cell Surface Proteins

    Hua Jing;Junichi Takagi;Jin-huan Liu;Sara Lindgren

  • The crystal structure of an N-terminal two-domain fragment of vascular cell adhesion molecule 1 (VCAM-1): a cyclic peptide based on the domain 1 C-D loop can inhibit VCAM-1-alpha 4 integrin interaction.

    Jia-Huai Wang;R. B. Pepinsky;T. Stehle;Jin-Huan Liu

Frequent Co-Authors

Ellis L. Reinherz
Ellis L. Reinherz Harvard University
Timothy A. Springer
Timothy A. Springer Boston Children's Hospital
Gerhard Wagner
Gerhard Wagner Harvard University
Andrzej Joachimiak
Andrzej Joachimiak Argonne National Laboratory
Rongguang Zhang
Rongguang Zhang Chinese Academy of Sciences
Jack Lawler
Jack Lawler Beth Israel Deaconess Medical Center
Rebecca E. Hussey
Rebecca E. Hussey Dana-Farber Cancer Institute
Motomu Shimaoka
Motomu Shimaoka Mie University
Stephen C. Harrison
Stephen C. Harrison Harvard University
Junichi Takagi
Junichi Takagi Osaka University

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