Motomu Shimaoka

Overview

Best Publications

• Conformational Regulation of Integrin Structure and Function

  Motomu Shimaoka;Junichi Takagi;Timothy A Springer

  701
  Citations

• Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

  Motomu Shimaoka;Tsan Sam Xiao;Jin Huan Liu;Yuting Yang

  640
  Citations

• Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target.

  Dan Peer;Eun Jeong Park;Yoshiyuki Morishita;Christopher V. Carman

  576
  Citations

• Therapeutic antagonists and conformational regulation of integrin function

  Motomu Shimaoka;Timothy A. Springer

  461
  Citations

• Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1

  Dan Peer;Pengcheng Zhu;Christopher V. Carman;Judy Lieberman

  338
  Citations

• Activation of Leukocyte β2 Integrins by Conversion from Bent to Extended Conformations

  Noritaka Nishida;Can Xie;Motomu Shimaoka;Yifan Cheng

  333
  Citations

• Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo

  Motomu Shimaoka;Chafen Lu;Roger T. Palframan;Ulrich H. von Andrian

  308
  Citations

• Identification of the target self-antigens in reperfusion injury

  Ming Zhang;Elisabeth M. Alicot;Isaac Chiu;Jinan Li

  262
  Citations

• Ventilator-induced lung injury is associated with neutrophil infiltration, macrophage activation, and TGF-beta 1 mRNA upregulation in rat lungs.

  Hideaki Imanaka;Motomu Shimaoka;Nariaki Matsuura;Masaji Nishimura

  261
  Citations

• Rolling Adhesion through an Extended Conformation of Integrin αLβ2 and Relation to α I and β I-like Domain Interaction

  Azucena Salas;Motomu Shimaoka;Avi N Kogan;Charlotte Harwood

  256
  Citations

• RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice.

  Sang Soo Kim;Dan Peer;Dan Peer;Priti Kumar;Sandesh Subramanya

  252
  Citations

• Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains

  Chafen Lu;Motomu Shimaoka;Qun Zang;Junichi Takagi

  242
  Citations

• Inflamed lymphatic endothelium suppresses dendritic cell maturation and function via Mac-1/ICAM-1-dependent mechanism.

  Simona Podgrabinska;Okebugwu Kamalu;Lloyd Mayer;Motomu Shimaoka

  213
  Citations

• Computational design of an integrin I domain stabilized in the open high affinity conformation.

  Motomu Shimaoka;Julia M. Shifman;Hua Jing;Junichi Takagi

  181
  Citations

• An isolated, surface-expressed I domain of the integrin αLβ2 is sufficient for strong adhesive function when locked in the open conformation with a disulfide bond

  Chafen Lu;Motomu Shimaoka;Mazen Ferzly;Claus Oxvig

  170
  Citations

• Set positive end-expiratory pressure during protective ventilation affects lung injury

  Muneyuki Takeuchi;Sven Goddon;Marisa Dolhnikoff;Motomu Shimaoka

  165
  Citations

• Nonmuscle myosin heavy chain IIA mediates integrin LFA-1 de-adhesion during T lymphocyte migration

  Nicole A. Morin;Patrick W. Oakes;Young-Min Hyun;Dooyoung Lee

  163
  Citations

• Importance of force linkage in mechanochemistry of adhesion receptors.

  Nathan S. Astrof;Azucena Salas;Motomu Shimaoka;JianFeng Chen

  162
  Citations

• Requirement of α and β subunit transmembrane helix separation for integrin outside-in signaling

  Jieqing Zhu;Christopher V. Carman;Minsoo Kim;Motomu Shimaoka

  161
  Citations

• Small Molecule Integrin Antagonists that Bind to the β2 Subunit I-like Domain and Activate Signals in One Direction and Block Them in the Other

  Motomu Shimaoka;Azucena Salas;Wei Yang;Gabriele Weitz-Schmidt

  159
  Citations