His primary scientific interests are in Integrin, Lymphocyte function-associated antigen 1, Biophysics, Cell adhesion and Stereochemistry. Motomu Shimaoka interconnects Ligand, Binding domain, Transmembrane domain, Intercellular Adhesion Molecule-1 and Conformational change in the investigation of issues within Integrin. His biological study spans a wide range of topics, including Small interfering RNA, Molecular biology, RNA interference, Lymphocyte and Gene silencing.
His Biophysics study incorporates themes from Allosteric regulation and Small molecule. His Cell adhesion research includes elements of Plasma protein binding, Signal transduction, G protein and Cell biology. His Stereochemistry study typically links adjacent topics like Protein structure.
Motomu Shimaoka focuses on Integrin, Cell biology, Cell adhesion, Immunology and Lymphocyte function-associated antigen 1. The study incorporates disciplines such as Ligand, Biophysics, Stereochemistry, Cell adhesion molecule and Allosteric regulation in addition to Integrin. Motomu Shimaoka has researched Stereochemistry in several fields, including Protein structure, Binding domain and Alpha.
His Cell biology research also works with subjects such as
His primary areas of study are Cell biology, Integrin, Inflammation, Microvesicles and Cell adhesion. His research in the fields of Homing, Crosstalk and Connexin overlaps with other disciplines such as Thrombomodulin. His Integrin study improves the overall literature in Receptor.
His Inflammation research is multidisciplinary, relying on both Myokine, Immune system and Sepsis. Motomu Shimaoka focuses mostly in the field of Microvesicles, narrowing it down to matters related to Endosome and, in some cases, Pannexin and Actin. As part of one scientific family, Motomu Shimaoka deals mainly with the area of Cell adhesion, narrowing it down to issues related to the Extracellular matrix, and often Flow cytometry, Ligand and Cell membrane.
Motomu Shimaoka mainly investigates Cell biology, Integrin, Microvesicles, Inflammation and Sepsis. His Cell biology research includes themes of Cancer cell, Cell morphology and Tube formation. His research in Integrin intersects with topics in Renal function, Central nervous system, Transmembrane protein, Systemic inflammatory response syndrome and Cell adhesion.
His Microvesicles research focuses on subjects like Homing, which are linked to Chemokine, Cell adhesion molecule and Immune system. His Inflammation research is multidisciplinary, incorporating elements of Extracellular, Serine, Peripheral blood mononuclear cell and Recombinant DNA. The Sepsis study combines topics in areas such as Lung injury, Receptor expression and Type 2 immune response.
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Conformational Regulation of Integrin Structure and Function
Motomu Shimaoka;Junichi Takagi;Timothy A Springer.
Annual Review of Biophysics and Biomolecular Structure (2002)
Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation
Motomu Shimaoka;Tsan Sam Xiao;Jin Huan Liu;Yuting Yang.
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target.
Dan Peer;Eun Jeong Park;Yoshiyuki Morishita;Christopher V. Carman.
Therapeutic antagonists and conformational regulation of integrin function
Motomu Shimaoka;Timothy A. Springer.
Nature Reviews Drug Discovery (2003)
Activation of Leukocyte β2 Integrins by Conversion from Bent to Extended Conformations
Noritaka Nishida;Can Xie;Motomu Shimaoka;Yifan Cheng.
Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1
Dan Peer;Pengcheng Zhu;Christopher V. Carman;Judy Lieberman.
Proceedings of the National Academy of Sciences of the United States of America (2007)
Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo
Motomu Shimaoka;Chafen Lu;Roger T. Palframan;Ulrich H. von Andrian.
Proceedings of the National Academy of Sciences of the United States of America (2001)
Identification of the target self-antigens in reperfusion injury
Ming Zhang;Elisabeth M. Alicot;Isaac Chiu;Jinan Li.
Journal of Experimental Medicine (2006)
Rolling Adhesion through an Extended Conformation of Integrin αLβ2 and Relation to α I and β I-like Domain Interaction
Azucena Salas;Motomu Shimaoka;Avi N Kogan;Charlotte Harwood.
Ventilator-Induced Lung Injury Is Associated with Neutrophil Infiltration, Macrophage Activation, and TGF-β1 mRNA Upregulation in Rat Lungs
Hideaki Imanaka;Motomu Shimaoka;Nariaki Matsuura;Masaji Nishimura.
Anesthesia & Analgesia (2001)
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