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Best Scientists
2025
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Biology and Biochemistry
USA
2026

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Best Scientists

D-Index
203
Citations
168801
World Ranking
260
National Ranking
171

Biology and Biochemistry

D-Index
204
Citations
170414
World Ranking
29
National Ranking
24

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2019 - Canada Gairdner International Award
  • 2013 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2004 - Fellow of John Simon Guggenheim Memorial Foundation
  • 2001 - Fellow of the American Academy of Arts and Sciences
  • 1996 - Member of the National Academy of Sciences

Overview

Timothy A. Springer is affiliated with Boston Children's Hospital in the United States. Their research spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a particular focus on Molecular Biology, Immunology and Allergy, Immunology, Radiology, Nuclear Medicine and Imaging, and Hematology.

Themes central to their work include Cell Adhesion Molecules Research, Monoclonal and Polyclonal Antibodies Research, Platelet Disorders and Treatments, Biochemical and Structural Characterization, Cellular Mechanics and Interactions, Force Microscopy Techniques and Applications, and TGF-β signaling in diseases.

Frequent co-authors collaborating with Timothy A. Springer include:

  • Jiabin Yan
  • Yuxin Hao
  • Chafen Lu
  • Taekjip Ha
  • Xianchi Dong

They have published extensively in several scientific venues, most notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biophysical Journal
  • Blood
  • Nature Communications
  • Journal of Biological Chemistry

Selected recent papers by Timothy A. Springer include:

  • A general chemical principle for creating closure-stabilizing integrin inhibitors, 2022, Cell
  • Ligand binding initiates single-molecule integrin conformational activation, 2024, Cell
  • Single-molecule characterization of subtype-specific β1 integrin mechanics, 2022, Nature Communications
  • De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8, 2023, Nature Communications
  • Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b, 2021, The Journal of Immunology

The scientist has been recognized with several awards and honors, including:

  • Canada Gairdner International Award, 2019
  • Fellow of the American Association for the Advancement of Science (AAAS), 2013
  • Fellow of John Simon Guggenheim Memorial Foundation, 2004
  • Fellow of the American Academy of Arts and Sciences, 2001
  • Member of the National Academy of Sciences, 1996

Best Publications

  • Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

    Timothy A. Springer

  • Adhesion receptors of the immune system.

    Timothy A. Springer

  • Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).

    Michael L. Dustin;Robert Rothlein;Atul K. Bhan;Charles A. Dinarello

  • Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins

    Michael B. Lawrence;Timothy A. Springer

  • The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.

    Conrad C. Bleul;Michael Farzan;Hyeryun Choe;Cristina Parolin;Cristina Parolin

  • Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)

    Steven D. Marlin;Timothy A. Springer

  • The Chemokine SDF-1 Is a Chemoattractant for Human CD34+ Hematopoietic Progenitor Cells and Provides a New Mechanism to Explain the Mobilization of CD34+ Progenitors to Peripheral Blood

    A. Aiuti;I.J. Webb;C. Bleul;T. Springer

  • T-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1

    Michael L. Dustin;Timothy A. Springer;Timothy A. Springer

  • Impaired B-lymphopoiesis, myelopoiesis, and derailed cerebellar neuron migration in CXCR4- and SDF-1-deficient mice

    Qing Ma;Dan Jones;Paul R. Borghesani;Rosalind A. Segal

  • TRAFFIC SIGNALS ON ENDOTHELIUM FOR LYMPHOCYTE RECIRCULATION AND LEUKOCYTE EMIGRATION

    T A Springer

  • Structural Basis of Integrin Regulation and Signaling

    Bing Hao Luo;Christopher V. Carman;Timothy A. Springer

  • A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

    Conrad C. Bleul;Robert C. Fuhlbrigge;Jose M. Casasnovas;Alessandro Aiuti

  • A HUMAN INTERCELLULAR ADHESION MOLECULE (ICAM-1) DISTINCT FROM LFA-1

    Robert Rothlein;Michael L. Dustin;Steven D. Marlin;Timothy A. Springer

  • Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.

    Jordan S. Pober;Michael A. Gimbrone;Lynne A. Lapierre;Donna L. Mendrick

  • Leukocyte adhesion deficiency: an inherited defect in the Mac-1, LFA-1, and p150,95 glycoproteins

    Anderson Dc;T A Springer

  • The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system.

    Timothy A. Springer;Michael L. Dustin;Takashi K. Kishimoto;Steven D. Marlin

  • Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant

    Michelle Woldemar Carr;Stephen J. Roth;Ed Luther;Shayla S. Rose

  • The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

    Conrad C. Bleul;Lijun Wu;James A. Hoxie;Timothy A. Springer

  • Lymphocyte Function-associated Antigen-1 (LFA-1) Interaction with Intercellular Adhesion Molecule-1 (ICAM-1) is One of At Least Three Mechanisms for Lymphocyte Adhesion to Cultured Endothelial Cells

    Michael L. Dustin;Timothy A. Springer

  • Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

    Junichi Takagi;Benjamin M. Petre;Thomas Walz;Timothy A. Springer

Frequent Co-Authors

Michael L. Dustin
Michael L. Dustin University of Oxford
Donald E. Staunton
Donald E. Staunton CisThera (United States)
Robert Rothlein
Robert Rothlein Boehringer Ingelheim (Germany)
Motomu Shimaoka
Motomu Shimaoka Mie University
Junichi Takagi
Junichi Takagi Osaka University
Michael S. Diamond
Michael S. Diamond Washington University in St. Louis
Christopher V. Carman
Christopher V. Carman Harvard University
Donald C. Anderson
Donald C. Anderson Baylor College of Medicine
Jia-huai Wang
Jia-huai Wang Harvard University
Ronen Alon
Ronen Alon Weizmann Institute of Science

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