Junichi Takagi

Overview

Best Publications

• Global Conformational Rearrangements in Integrin Extracellular Domains in Outside-In and Inside-Out Signaling

  Junichi Takagi;Benjamin M. Petre;Thomas Walz;Timothy A. Springer

  1454
  Citations

• Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics

  Tsars Xiao;Junichi Takagi;Junichi Takagi;Barry S. Coller;Jia-Huai Wang

  999
  Citations

• Conformational Regulation of Integrin Structure and Function

  Motomu Shimaoka;Junichi Takagi;Timothy A Springer

  701
  Citations

• Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

  Motomu Shimaoka;Tsan Sam Xiao;Jin Huan Liu;Yuting Yang

  640
  Citations

• Integrin activation and structural rearrangement.

  Junichi Takagi;Timothy A. Springer

  558
  Citations

• Human Pancreatic Tumor Organoids Reveal Loss of Stem Cell Niche Factor Dependence during Disease Progression

  Takashi Seino;Shintaro Kawasaki;Mariko Shimokawa;Hiroki Tamagawa

  529
  Citations

• Ligand-binding specificities of laminin-binding integrins: A comprehensive survey of laminin–integrin interactions using recombinant α3β1, α6β1, α7β1 and α6β4 integrins

  Ryoko Nishiuchi;Junichi Takagi;Maria Hayashi;Hiroyuki Ido

  490
  Citations

• Structure of integrin α5β1 in complex with fibronectin

  Junichi Takagi;Junichi Takagi;Konstantin Strokovich;Timothy A. Springer;Thomas Walz

  474
  Citations

• Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation.

  Natalia Beglova;Stephen C. Blacklow;Junichi Takagi;Timothy A. Springer

  445
  Citations

• Semaphorin 7A initiates T-cell-mediated inflammatory responses through α1β1 integrin

  Kazuhiro Suzuki;Tatsusada Okuno;Midori Yamamoto;R. Jeroen Pasterkamp

  386
  Citations

• C-terminal Opening Mimics 'Inside-Out' Activation of Integrin alpha5beta1

  Junichi Takagi;Harold P. Erickson;Timothy A. Springer

  364
  Citations

• Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair.

  Hyesung Jeon;Wuyi Meng;Junichi Takagi;Michael J. Eck

  322
  Citations

• Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo

  Motomu Shimaoka;Chafen Lu;Roger T. Palframan;Ulrich H. von Andrian

  308
  Citations

• Crystal structure of α5β1 integrin ectodomain: Atomic details of the fibronectin receptor

  Masamichi Nagae;Suyong Re;Emiko Mihara;Terukazu Nogi

  278
  Citations

• Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

  Hiroshi Nishimasu;Shinichi Okudaira;Kotaro Hama;Emiko Mihara

  278
  Citations

• The RGD motif in fibronectin is essential for development but dispensable for fibril assembly

  Seiichiro Takahashi;Michael Leiss;Markus Moser;Tomoo Ohashi

  256
  Citations

• A Specific Interface between Integrin Transmembrane Helices and Affinity for Ligand

  Bing Hao Luo;Timothy A. Springer;Junichi Takagi

  252
  Citations

• Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains

  Chafen Lu;Motomu Shimaoka;Qun Zang;Junichi Takagi

  242
  Citations

• Epitope Mapping of Antibodies to the C-Terminal Region of the Integrin β2 Subunit Reveals Regions that Become Exposed Upon Receptor Activation

  Chafen Lu;Mazen Ferzly;Junichi Takagi;Timothy A. Springer

  239
  Citations

• Association of the Membrane Proximal Regions of the α and β Subunit Cytoplasmic Domains Constrains an Integrin in the Inactive State

  Chafen Lu;Junichi Takagi;Timothy A. Springer

  227
  Citations