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Chemistry
USA
2026

D-Index & Metrics

Chemistry

D-Index
136
Citations
64450
World Ranking
244
National Ranking
116

Biology and Biochemistry

D-Index
136
Citations
65422
World Ranking
339
National Ranking
228

William F. DeGrado publication distribution in Chemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Chemistry in 2026. The highlighted bar marks where William F. DeGrado sits on this spectrum.

61–80 publications: 66 scientists 81–100 publications: 302 scientists 101–120 publications: 623 scientists 121–140 publications: 918 scientists 141–160 publications: 1,218 scientists 161–180 publications: 1,350 scientists 181–200 publications: 1,344 scientists 201–220 publications: 1,281 scientists 221–240 publications: 1,216 scientists 241–260 publications: 1,100 scientists 261–280 publications: 979 scientists 281–300 publications: 939 scientists 301–320 publications: 764 scientists 321–340 publications: 644 scientists 341–360 publications: 628 scientists 361–380 publications: 522 scientists 381–400 publications: 459 scientists 401–420 publications: 397 scientists 421–440 publications: 327 scientists 441–460 publications: 270 scientists 461–480 publications: 265 scientists 481–500 publications: 253 scientists 501–520 publications: 201 scientists 521–540 publications: 185 scientists 541–560 publications: 148 scientists 561–580 publications: 148 scientists 581–600 publications: 132 scientists 601–620 publications: 114 scientists 621–640 publications: 104 scientists 641–660 publications: 91 scientists 661–680 publications: 92 scientists 681–700 publications: 73 scientists 701–720 publications: 57 scientists 721–740 publications: 54 scientists 741–760 publications: 67 scientists 761–780 publications: 45 scientists 781–800 publications: 46 scientists 801–820 publications: 39 scientists 821–840 publications: 32 scientists 841–860 publications: 36 scientists 861–880 publications: 29 scientists 881–900 publications: 26 scientists 901–920 publications: 24 scientists 921–940 publications: 14 scientists 941–960 publications: 23 scientists 961–980 publications: 28 scientists 981–1,000 publications: 15 scientists 1,001–1,020 publications: 29 scientists 1,021–1,040 publications: 12 scientists 1,041–1,060 publications: 19 scientists 1,061–1,080 publications: 12 scientists 1,081–1,100 publications: 6 scientists 1,101–1,120 publications: 8 scientists 1,121–1,140 publications: 12 scientists 1,141–1,160 publications: 5 scientists 1,161–1,180 publications: 6 scientists 1,181–1,200 publications: 14 scientists 1,201–1,220 publications: 7 scientists 1,221–1,240 publications: 2 scientists 1,241–1,260 publications: 6 scientists 1,261–1,280 publications: 4 scientists 1,281–1,294 publications: 6 scientists 1,295+ publications: 100 scientists
61 publications 1,295+

This scientist: 722 publications — 96th percentile

96% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,295 publications or more.

William F. DeGrado D-index placement in Chemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Chemistry scientists ranked by Research.com in 2026. The highlighted bar marks where William F. DeGrado sits on this spectrum.

40–41 D-Index: 289 scientists 42–43 D-Index: 612 scientists 44–45 D-Index: 808 scientists 46–47 D-Index: 776 scientists 48–49 D-Index: 835 scientists 50–51 D-Index: 861 scientists 52–53 D-Index: 872 scientists 54–55 D-Index: 933 scientists 56–57 D-Index: 1,051 scientists 58–59 D-Index: 930 scientists 60–61 D-Index: 882 scientists 62–63 D-Index: 834 scientists 64–65 D-Index: 731 scientists 66–67 D-Index: 776 scientists 68–69 D-Index: 683 scientists 70–71 D-Index: 647 scientists 72–73 D-Index: 561 scientists 74–75 D-Index: 501 scientists 76–77 D-Index: 437 scientists 78–79 D-Index: 388 scientists 80–81 D-Index: 354 scientists 82–83 D-Index: 292 scientists 84–85 D-Index: 275 scientists 86–87 D-Index: 254 scientists 88–89 D-Index: 235 scientists 90–91 D-Index: 185 scientists 92–93 D-Index: 192 scientists 94–95 D-Index: 155 scientists 96–97 D-Index: 163 scientists 98–99 D-Index: 125 scientists 100–101 D-Index: 105 scientists 102–103 D-Index: 105 scientists 104–105 D-Index: 112 scientists 106–107 D-Index: 88 scientists 108–109 D-Index: 68 scientists 110–111 D-Index: 69 scientists 112–113 D-Index: 65 scientists 114–115 D-Index: 79 scientists 116–117 D-Index: 61 scientists 118–119 D-Index: 44 scientists 120–121 D-Index: 37 scientists 122–123 D-Index: 40 scientists 124–125 D-Index: 33 scientists 126–127 D-Index: 26 scientists 128–129 D-Index: 34 scientists 130–131 D-Index: 35 scientists 132–133 D-Index: 25 scientists 134–135 D-Index: 27 scientists 136–137 D-Index: 17 scientists 138–139 D-Index: 16 scientists 140–141 D-Index: 20 scientists 142–143 D-Index: 20 scientists 144–145 D-Index: 15 scientists 146–147 D-Index: 9 scientists 148–149 D-Index: 9 scientists 150–151 D-Index: 16 scientists 152–153 D-Index: 11 scientists 154–155 D-Index: 9 scientists 156–157 D-Index: 3 scientists 158 D-Index: 3 scientists 159+ D-Index: 98 scientists
40 D-Index 159+

This scientist: 136 D-Index — 99th percentile

99% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 159 D-Index or more.

Research.com Recognitions

  • 2026 - Research.com Chemistry in United States Leader Award
  • 2025 - Research.com Chemistry in United States Leader Award
  • 2017 - Murray Goodman Memorial Prize, American Chemical Society (ACS)
  • 2013 - Fellow, National Academy of Inventors
  • 1999 - Member of the National Academy of Sciences
  • 1998 - Fellow of the American Academy of Arts and Sciences
  • 1994 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

William F. DeGrado is affiliated with the University of California, San Francisco in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine. Within these domains, their work notably focuses on Molecular Biology, Materials Chemistry, Neurology, Physiology, and Organic Chemistry.

The main topics addressed in DeGrado's research include:

  • Protein Structure and Dynamics
  • RNA and protein synthesis mechanisms
  • Alzheimer's disease research and treatments
  • Chemical Synthesis and Analysis
  • Enzyme Structure and Function
  • Lipid Membrane Structure and Behavior
  • Monoclonal and Polyclonal Antibodies Research

Several recent publications exemplify the scope of their work, including:

  • De novo protein design, a retrospective (2020) in Quarterly Reviews of Biophysics
  • A defined structural unit enables de novo design of small-molecule-binding proteins (2020) in Science
  • Constructing ion channels from water-soluble α-helical barrels (2021) in Nature Chemistry
  • De novo metalloprotein design (2021) in Nature Reviews Chemistry
  • Deep mutational scanning reveals the structural basis for α-synuclein activity (2020) in Nature Chemical Biology

DeGrado has collaborated frequently with several coauthors, most notably:

  • Hyunil Jo
  • Sophia K. Tan
  • Nicholas F. Polizzi
  • Carlo Condello
  • Huong T. Kratochvil

Their research findings have been published extensively in venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of the American Chemical Society
  • Proceedings of the National Academy of Sciences
  • Biophysical Journal
  • Biochemistry

Throughout their career, William F. DeGrado has received several recognitions:

  • Murray Goodman Memorial Prize, American Chemical Society (ACS), 2017
  • Fellow, National Academy of Inventors, 2013
  • Member of the National Academy of Sciences, 1999
  • Fellow of the American Academy of Arts and Sciences, 1998
  • Fellow of the American Association for the Advancement of Science (AAAS), 1994

Best Publications

  • beta-Peptides: from structure to function.

    Richard P. Cheng;Samuel H. Gellman;William F. DeGrado

  • A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids

    Karyn T. O'Neil;William F. Degrado

  • How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

    Karyn T. O'Neil;William F. DeGrado

  • Foldamers as versatile frameworks for the design and evolution of function

    Catherine M Goodman;Sungwook Choi;Sungwook Choi;Scott Shandler;William F DeGrado

  • Characterization of a helical protein designed from first principles

    Lynne Regan;William F. DeGrado

  • De Novo Design and Structural Characterization of Proteins and Metalloproteins

    William F. DeGrado;Christopher M. Summa;Vincenzo Pavone;Flavia Nastri

  • Synthetic amphiphilic peptide models for protein ion channels

    JD Lear;ZR Wasserman;WF DeGrado

  • Protein Design: A Hierarchic Approach

    James W. Bryson;Stephen F. Betz;Helen S. Lu;Daniel J. Suich

  • Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers

    Sarah D. Cady;Klaus Schmidt-Rohr;Jun Wang;Cinque S. Soto

  • Structural basis for the function and inhibition of an influenza virus proton channel

    Amanda L. Stouffer;Amanda L. Stouffer;Rudresh Acharya;David Salom;Anna S. Levine

  • Protein design, a minimalist approach

    William F. DeGrado;Zelda R. Wasserman;James D. Lear

  • Short peptides self-assemble to produce catalytic amyloids

    Caroline M. Rufo;Yurii S. Moroz;Olesia V. Moroz;Jan Stöhr

  • De Novo Design of Antimicrobial Polymers, Foldamers, and Small Molecules: From Discovery to Practical Applications

    Gregory N. Tew;Richard W. Scott;Michael L. Klein;William F. DeGrado

  • Design and synthesis of multi-haem proteins

    D E Robertson;R S Farid;C C Moser;J L Urbauer

  • De novo design of biomimetic antimicrobial polymers

    Gregory N. Tew;Dahui Liu;Bin Chen;Robert J. Doerksen

  • Amphiphilic polymethacrylate derivatives as antimicrobial agents.

    Kenichi Kuroda;William F. DeGrado

  • Folding of helical membrane proteins: the role of polar, GxxxG-like and proline motifs.

    Alessandro Senes;Donald E Engel;William F DeGrado

  • A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity.

    Lawrence H. Pinto;Gregg R. Dieckmann;Chris S. Gandhi;Carol G. Papworth

  • Induction of peptide conformation at apolar water interfaces. 1. A study with model peptides of defined hydrophobic periodicity

    W. F. DeGrado;J. D. Lear

  • De Novo Design of Antibacterial β-Peptides

    Yoshi Hamuro;and Joel P. Schneider;William F. DeGrado

Frequent Co-Authors

James D. Lear
James D. Lear University of Pennsylvania
Joel S. Bennett
Joel S. Bennett University of Pennsylvania
Feng Gai
Feng Gai University of Pennsylvania
Michael L. Klein
Michael L. Klein Temple University
Angela Lombardi
Angela Lombardi University of Naples Federico II
Robert A. Lamb
Robert A. Lamb Northwestern University
Lawrence H. Pinto
Lawrence H. Pinto Northwestern University
Gregory N. Tew
Gregory N. Tew University of Massachusetts Amherst
Vincenzo Pavone
Vincenzo Pavone University of Naples Federico II

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