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Biology and Biochemistry
Israel
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
94
Citations
32366
World Ranking
2010
National Ranking
20

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Israel Leader Award
  • 2022 - Research.com Biology and Biochemistry in Israel Leader Award

Overview

Yechiel Shai is affiliated with the Weizmann Institute of Science in Israel. Their research primarily focuses on antimicrobial peptides and their interactions with bacterial pathogens, emphasizing biochemical and molecular mechanisms of resistance and activity.

The scientist's recent publications cover various aspects of antimicrobial peptides, including their synthesis, structural characterization, and effects on multidrug-resistant bacteria. Key papers include:

  • Antimicrobial Peptides against Multidrug-Resistant Pseudomonas aeruginosa Biofilm from Cystic Fibrosis Patients, 2022, Journal of Medicinal Chemistry
  • Site-Specific Isopeptide Bond Formation: A Powerful Tool for the Generation of Potent and Nontoxic Antimicrobial Peptides, 2022, Journal of Medicinal Chemistry
  • Opposing Effects of PhoPQ and PmrAB on the Properties of Salmonella enterica serovar Typhimurium: Implications on Resistance to Antimicrobial Peptides, 2021, Biochemistry
  • Loss of the Periplasmic Chaperone Skp and Mutations in the Efflux Pump AcrAB-TolC Play a Role in Acquired Resistance to Antimicrobial Peptides in Salmonella typhimurium, 2020, Frontiers in Microbiology
  • Switching Bond: Generation of New Antimicrobial Peptides via the Incorporation of an Intramolecular Isopeptide Bond, 2021, ACS Infectious Diseases

Frequent co-authors include:

  • Naiem Ahmad Wani
  • Daniel Ben Hur
  • Gal Kapach
  • Edo Kiper
  • Elad Stolovicki

Shai's work is commonly published in venues such as:

  • Journal of Medicinal Chemistry
  • Biochemistry
  • ACS Infectious Diseases
  • Frontiers in Microbiology
  • Antibiotics

Their main fields of study encompass:

  • Biochemistry, Genetics and Molecular Biology
  • Immunology and Microbiology

Within these fields, Shai's subfields of research include:

  • Molecular Biology
  • Microbiology
  • Food Science
  • Ecology
  • Emergency Medical Services

The primary topics of their work cover:

  • Antimicrobial Peptides and Activities
  • Biochemical and Structural Characterization
  • RNA Interference and Gene Delivery
  • Probiotics and Fermented Foods
  • Bacterial biofilms and quorum sensing
  • Chemical Synthesis and Analysis
  • Bacteriophages and microbial interactions

Overall, the scientist's research combines biochemical methodologies with microbiological perspectives to investigate mechanisms of bacterial resistance and to develop new antimicrobial agents targeting pathogenic bacteria, particularly in drug-resistant contexts.

Best Publications

  • Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.

    Yechiel Shai

  • Mode of action of membrane active antimicrobial peptides.

    Yechiel Shai

  • Mode of action of linear amphipathic α-helical antimicrobial peptides

    Ziv Oren;Yechiel Shai

  • Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes.

    Yehonathan Pouny;Doron Rapaport;Amram Mor;Pierre Nicolas

  • Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.

    Ziv Oren;Jeffrey C. Lerman;Gudmundur H. Gudmundsson;Birgitta Agerberth

  • Host defense peptides as new weapons in cancer treatment.

    N Papo;Y Shai

  • Ultrashort antibacterial and antifungal lipopeptides

    Arik Makovitzki;Dorit Avrahami;Yechiel Shai

  • Selective lysis of bacteria but not mammalian cells by diastereomers of melittin: structure-function study

    Ziv Oren;Yechiel Shai

  • Endotoxin (Lipopolysaccharide) Neutralization by Innate Immunity Host-Defense Peptides PEPTIDE PROPERTIES AND PLAUSIBLE MODES OF ACTION

    Yosef Rosenfeld;Niv Papo;Yechiel Shai

  • From "carpet" mechanism to de-novo designed diastereomeric cell-selective antimicrobial peptides.

    Yechiel Shai;Ziv Oren

  • Interaction of the mammalian antibacterial peptide cecropin P1 with phospholipid vesicles.

    Ehud Gazit;Anita Boman;Hans G. Boman;Yechiel Shai

  • Can we predict biological activity of antimicrobial peptides from their interactions with model phospholipid membranes

    Niv Papo;Yechiel Shai

  • Lipopolysaccharide (Endotoxin)-host defense antibacterial peptides interactions: role in bacterial resistance and prevention of sepsis.

    Yosef Rosenfeld;Yechiel Shai

  • Molecular recognition between membrane-spanning polypeptides

    Yechiel Shai

  • Why Bacillus thuringiensis insecticidal toxins are so effective: unique features of their mode of action

    Arthur I. Aronson;Yechiel Shai

  • Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes.

    Ehud Gazit;Israel R. Miller;Israel R. Miller;Phil C. Biggin;Phil C. Biggin;Mark S.P. Sansom;Mark S.P. Sansom

  • A class of highly potent antibacterial peptides derived from pardaxin, a pore-forming peptide isolated from Moses sole fish Pardachirus marmoratus

    Ziv Oren;Yechiel Shai

  • A molecular mechanism for lipopolysaccharide protection of Gram-negative bacteria from antimicrobial peptides.

    Niv Papo;Yechiel Shai

  • Exploring Peptide Membrane Interaction Using Surface Plasmon Resonance: Differentiation between Pore Formation versus Membrane Disruption by Lytic Peptides†

    Niv Papo;Yechiel Shai

  • The Consequence of Sequence Alteration of an Amphipathic α-Helical Antimicrobial Peptide and Its Diastereomers

    Niv Papo;Ziv Oren;Ulrike Pag;Hans-George Sahl

Frequent Co-Authors

Maria Luisa Mangoni
Maria Luisa Mangoni Sapienza University of Rome
Ehud Gazit
Ehud Gazit Tel Aviv University
Irun R. Cohen
Irun R. Cohen Weizmann Institute of Science
Doron Rapaport
Doron Rapaport University of Tübingen
Richard M. Epand
Richard M. Epand McMaster University
Hans-Georg Sahl
Hans-Georg Sahl University of Bonn
Robert Blumenthal
Robert Blumenthal University of Toledo
Robert Blumenthal
Robert Blumenthal National Institutes of Health
Francisco J. Quintana
Francisco J. Quintana Harvard Medical School
Daniella Goldfarb
Daniella Goldfarb Weizmann Institute of Science

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