D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 52 Citations 7,476 141 World Ranking 8849 National Ranking 3952

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cancer
  • Enzyme

Eugene W. Gerner focuses on Polyamine, Spermidine, Ornithine decarboxylase, Spermine and Biochemistry. The concepts of his Polyamine study are interwoven with issues in Carcinogenesis, Molecular biology, Pharmacology and Ornithine. His study in the field of Putrescine transport also crosses realms of Eukaryotic initiation factor, Deoxyhypusine synthase and Deoxyhypusine Hydroxylase.

His Ornithine decarboxylase research incorporates elements of Cancer, Internal medicine, Adenoma, Pathology and Polyamine Catabolism. His Spermine research integrates issues from Ornithine decarboxylase antizyme, Putrescine, Arginine and Gene expression. His work on Cell growth, Enzyme, Dissociation constant and IC50 is typically connected to Decarboxylation as part of general Biochemistry study, connecting several disciplines of science.

His most cited work include:

  • Polyamines and cancer: old molecules, new understanding (828 citations)
  • Induced thermal resistance in HeLa cells (428 citations)
  • Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial (396 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Polyamine, Spermidine, Biochemistry, Ornithine decarboxylase and Molecular biology. His study in Polyamine is interdisciplinary in nature, drawing from both Endocrinology, Putrescine, Polyamine Catabolism, Internal medicine and Pharmacology. His biological study spans a wide range of topics, including Ornithine decarboxylase antizyme, Intestinal mucosa, Intracellular, Spermine and Barrett's esophagus.

His work on Chinese hamster ovary cell, Enzyme and Growth inhibition as part of his general Biochemistry study is frequently connected to Hypusine, thereby bridging the divide between different branches of science. The concepts of his Ornithine decarboxylase study are interwoven with issues in Enzyme assay, Cell growth, Ornithine and Pathology. His Molecular biology research also works with subjects such as

  • Cell culture together with Cell biology,
  • Cell cycle that connect with fields like Mitosis.

He most often published in these fields:

  • Polyamine (36.21%)
  • Spermidine (27.98%)
  • Biochemistry (25.10%)

What were the highlights of his more recent work (between 2009-2019)?

  • Internal medicine (21.81%)
  • Polyamine (36.21%)
  • Colorectal cancer (17.28%)

In recent papers he was focusing on the following fields of study:

His primary areas of investigation include Internal medicine, Polyamine, Colorectal cancer, Sulindac and Cancer research. His Internal medicine study combines topics in areas such as Gastroenterology, Endocrinology, Surgery and Oncology. His work deals with themes such as Spermidine, Polyamine transport, Spermine and Ornithine decarboxylase, which intersect with Polyamine.

His Spermidine study frequently links to adjacent areas such as Putrescine. His Ornithine decarboxylase study combines topics from a wide range of disciplines, such as Ornithine, Pharmacology and Neuroblastoma. His Cancer research research is multidisciplinary, incorporating elements of Cancer stem cell, Polyamine Catabolism, Caveolin 1, Adenomatous polyposis coli and Familial adenomatous polyposis.

Between 2009 and 2019, his most popular works were:

  • A Phase I Trial of DFMO Targeting Polyamine Addiction in Patients with Relapsed/Refractory Neuroblastoma (69 citations)
  • Targeting Polyamines and Inflammation for Cancer Prevention (59 citations)
  • Vitamin D receptor ligands, adenomatous polyposis coli, and the vitamin D receptor FokI polymorphism collectively modulate β‐catenin activity in colon cancer cells (54 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Enzyme
  • Cancer

Polyamine, Internal medicine, Cancer research, Spermidine and Endocrinology are his primary areas of study. Eugene W. Gerner interconnects Polyamine transport and Ornithine decarboxylase in the investigation of issues within Polyamine. The various areas that he examines in his Ornithine decarboxylase study include Neuroblastoma and Oncology.

Eugene W. Gerner has researched Cancer research in several fields, including Protein kinase B, Cell migration, Polyamine Catabolism, Tumor suppressor gene and Adenomatous polyposis coli. His Spermidine research includes themes of Colorectal adenoma, Gastroenterology and Spermine. His studies in Spermine integrate themes in fields like Putrescine and Adenoma.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Surrogate end-point biomarkers as measures of colon cancer risk and their use in cancer chemoprevention trials.

Janine G. Einspahr;David S. Alberts;Susan M. Gapstur;Roberd M. Bostick.
Cancer Epidemiology, Biomarkers & Prevention (1997)

1909 Citations

Polyamines and cancer: old molecules, new understanding

Eugene W. Gerner;Frank L. Meyskens.
Nature Reviews Cancer (2004)

1114 Citations

Induced thermal resistance in HeLa cells

Eugene W. Gerner;Michael J. Schneider.
Nature (1975)

674 Citations

Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: A randomized placebo-controlled, double-blind trial

Frank L. Meyskens;Christine E. McLaren;Daniel Pelot;Sharon Fujikawa-Brooks.
Cancer Prevention Research (2008)

492 Citations

Development of difluoromethylornithine (DFMO) as a chemoprevention agent.

Frank L. Meyskens;Eugene W. Gerner.
Clinical Cancer Research (1999)

435 Citations

Dietary polyamine intake and risk of colorectal adenomatous polyps.

Ashley J Vargas;Betsy C Wertheim;Eugene W Gerner;Cynthia A Thomson.
The American Journal of Clinical Nutrition (2012)

375 Citations

Clinical hyperthermia: results of a phase I trial employing hyperthermia alone or in combination with external beam or interstitial radiotherapy.

Michael R. Manning;Thomas C. Cetas;Robert C. Miller;James R. Oleson.
Cancer (1982)

307 Citations

Heat Shock Proteins in Thermotolerance and Other Cellular Processes

Stephen W. Carper;John J. Duffy;Eugene W. Gerner.
Cancer Research (1987)

300 Citations

Different bile acids exhibit distinct biological effects: The tumor promoter deoxycholic acid induces apoptosis and the chemopreventive agent ursodeoxycholic acid inhibits cell proliferation

Jesse D. Martinez;Elias D. Stratagoules;Janna M. LaRue;Ashley A. Powell.
Nutrition and Cancer (1998)

276 Citations

Pronounced reduction in adenoma recurrence associated with aspirin use and a polymorphism in the ornithine decarboxylase gene.

María Elena Martínez;Thomas G. O'Brien;Kimberly E. Fultz;Naveen Babbar.
Proceedings of the National Academy of Sciences of the United States of America (2003)

265 Citations

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