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Biology and Biochemistry

D-Index
52
Citations
11868
World Ranking
16552
National Ranking
6850

Research.com Recognitions

  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2014 - Fellow of the American Chemical Society

Overview

Patrick M. Woster is affiliated with the Medical University of South Carolina in the United States. Their work focuses on various aspects of biochemistry, genetics, and molecular biology, with significant contributions to medicine as well.

Their recent publications cover a range of topics related to molecular biology and disease mechanisms. Notable papers include:

  • "Mitochondrial depolarization after acute ethanol treatment drives mitophagy in living mice" (2022, Autophagy)
  • "Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling" (2020, Oncogene)
  • "Epigenetic Reexpression of Hemoglobin F Using Reversible LSD1 Inhibitors: Potential Therapies for Sickle Cell Disease" (2020, ACS Omega)
  • "Small molecules targeting the NADH-binding pocket of VDAC modulate mitochondrial metabolism in hepatocarcinoma cells" (2022, Biomedicine & Pharmacotherapy)
  • "Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modulator and Displays Therapeutic Synergy With PD-1-blockade" (2021, Journal of Immunotherapy)

The fields in which Patrick M. Woster has conducted research include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

They have worked extensively on subfields such as:

  • Molecular Biology
  • Physiology
  • Surgery
  • Neurology
  • Pharmacology

Key research topics covered in their work are:

  • Polyamine Metabolism and Applications
  • Epigenetics and DNA Methylation
  • Mitochondrial Function and Pathology
  • ATP Synthase and ATPases Research
  • Neuroblastoma Research and Treatments
  • Cancer Research and Treatments
  • Amino Acid Enzymes and Metabolism

They have published frequently in venues such as:

  • Journal of Clinical and Translational Science
  • Autophagy
  • Oncogene
  • Journal of Immunotherapy
  • Molecules

Frequent co-authors collaborating with Patrick M. Woster include:

  • Yuri K. Peterson
  • Catherine M. Mills
  • Amelia Furbish
  • Pieter B. Burger
  • Mónika Göőz

Throughout their career, they have received recognition including being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2017 and a Fellow of the American Chemical Society in 2014.

Best Publications

  • The natural polyamine spermine functions directly as a free radical scavenger

    Hyo Chol Ha;Nilantha S. Sirisoma;Periannan Kuppusamy;Jay L. Zweier

  • Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

    Tino Schenk;Weihsu Claire Chen;Stefanie Göllner;Louise Howell

  • Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.

    Andrew C. Goodwin;Christina E. Destefano Shields;Shaoguang Wu;David L. Huso

  • Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents : Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

    Phyllissa Schmiedlin-Ren;David J. Edwards;Michael E. Fitzsimmons;Kan He

  • Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

    Yi Huang;Eriko Greene;Tracy Murray Stewart;Andrew C. Goodwin

  • The role of polyamine catabolism in polyamine analogue-induced programmed cell death

    Hyo Chol Ha;Patrick M. Woster;James D. Yager;Robert A. Casero

  • 6',7'-Dihydroxybergamottin in grapefruit juice and Seville orange juice: effects on cyclosporine disposition, enterocyte CYP3A4, and P-glycoprotein.

    David J. Edwards;Michael E. Fitzsimmons;Erin G. Schuetz;Kazuto Yasuda

  • Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide

    J. E. Rider;J. E. Rider;A. Hacker;C. A. Mackintosh;A. E. Pegg

  • Polyamines and cancer: implications for chemotherapy and chemoprevention

    Shannon L. Nowotarski;Patrick M. Woster;Robert A. Casero

  • Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure.

    Yanlin Wang;Wendy Devereux;Patrick M. Woster;Tracy Murray Stewart

  • Terminally alkylated polyamine analogues as chemotherapeutic agents

    Robert A. Casero;Patrick M. Woster

  • Identification of 6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice.

    D J Edwards;F H Bellevue;P M Woster

  • Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes

    Yi Huang;Tracy Murray Stewart;Yu Wu;Stephen B. Baylin

  • Polyamine catabolism and oxidative damage

    Tracy Murray Stewart;Tiffany T. Dunston;Patrick M. Woster;Robert A. Casero

  • Recent Advances in the Development of Polyamine Analogues as Antitumor Agents

    Robert A. Casero;Patrick M. Woster

  • A role for bioactivation and covalent binding within epidermal keratinocytes in sulfonamide-induced cutaneous drug reactions

    Timothy P. Reilly;Lawrence H. Lash;Mark A. Doll;David W. Hein

  • Targeting polyamine metabolism for cancer therapy and prevention

    Tracy R. Murray-Stewart;Patrick M. Woster;Robert A. Casero

  • Properties of purified recombinant human polyamine oxidase, PAOh1/SMO.

    Yanlin Wang;Tracy Murray-Stewart;Wendy Devereux;Amy Hacker

  • (Bis)urea and (bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators.

    Shiv K. Sharma;Yu Wu;Nora Steinbergs;Michael L. Crowley

  • Spermine Oxidase SMO(PAOh1), Not N1-Acetylpolyamine Oxidase PAO, Is the Primary Source of Cytotoxic H2O2 in Polyamine Analogue-treated Human Breast Cancer Cell Lines

    Allison Pledgie;Yi Huang;Amy Hacker;Zhe Zhang

Frequent Co-Authors

Robert A. Casero
Robert A. Casero Johns Hopkins University School of Medicine
Nancy E. Davidson
Nancy E. Davidson University of Washington
Cyrus J. Bacchi
Cyrus J. Bacchi Pace University
Anthony E. Pegg
Anthony E. Pegg Pennsylvania State University
George Wilding
George Wilding University of Wisconsin–Madison
Louis M. Weiss
Louis M. Weiss Albert Einstein College of Medicine
Paul F. Hollenberg
Paul F. Hollenberg University of Michigan–Ann Arbor
John E. Dick
John E. Dick Princess Margaret Cancer Centre
Keith T. Wilson
Keith T. Wilson Vanderbilt University Medical Center

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