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Biology and Biochemistry

D-Index
88
Citations
30375
World Ranking
2686
National Ranking
1393

Overview

Robert A. Casero is affiliated with Johns Hopkins University School of Medicine in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with significant contributions in Medicine. The scientist's work is particularly focused on Molecular Biology, Biochemistry, and Pharmacology, alongside additional interests in Surgery and Cell Biology.

The main topics addressed in Robert A. Casero's research include:

  • Polyamine Metabolism and Applications
  • Epigenetics and DNA Methylation
  • Amino Acid Enzymes and Metabolism
  • Cannabis and Cannabinoid Research
  • Histone Deacetylase Inhibitors Research
  • Cancer Research and Treatments
  • Autophagy in Disease and Therapy

Among their recent scholarly papers are:

  • Polyamines in cancer: integrating organismal metabolism and antitumour immunity, 2022, Nature Reviews. Cancer
  • Inhibition of the polyamine synthesis enzyme ornithine decarboxylase sensitizes triple-negative breast cancer cells to cytotoxic chemotherapy, 2020, Journal of Biological Chemistry
  • Spermine oxidase mediates Helicobacter pylori-induced gastric inflammation, DNA damage, and carcinogenic signaling, 2020, Oncogene
  • Pharmacological polyamine catabolism upregulation with methionine salvage pathway inhibition as an effective prostate cancer therapy, 2020, Nature Communications
  • Autophagy induction by exogenous polyamines is an artifact of bovine serum amine oxidase activity in culture serum, 2020, Journal of Biological Chemistry

Robert A. Casero frequently collaborates with a number of co-authors. Notable frequent co-authors include:

  • Tracy Murray Stewart
  • Jackson R. Foley
  • Cassandra E. Holbert
  • Ashley Nwafor
  • Matthew Dunworth

Their publications have appeared in several recurring venues, such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Research
  • Journal of Biological Chemistry
  • International Journal of Molecular Sciences
  • Medical Sciences

Best Publications

  • The natural polyamine spermine functions directly as a free radical scavenger

    Hyo Chol Ha;Nilantha S. Sirisoma;Periannan Kuppusamy;Jay L. Zweier

  • DPC4 Gene in Various Tumor Types

    Mieke Schutte;Ralph H. Hruban;Lora Hedrick;Kathleen R. Cho

  • Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases

    Robert A. Casero;Laurence J. Marton

  • Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

    Tino Schenk;Weihsu Claire Chen;Stefanie Göllner;Louise Howell

  • Polyamine metabolism and cancer: treatments, challenges and opportunities

    Robert A. Casero;Tracy Murray Stewart;Anthony E. Pegg

  • Oxidative Damage Targets Complexes Containing DNA Methyltransferases, SIRT1, and Polycomb Members to Promoter CpG Islands

    Heather M. O'Hagan;Wei Wang;Subhojit Sen;Christina DeStefano Shields

  • Polyamine catabolism contributes to enterotoxigenic Bacteroides fragilis-induced colon tumorigenesis.

    Andrew C. Goodwin;Christina E. Destefano Shields;Shaoguang Wu;David L. Huso

  • Spermidine/spermine N1-acetyltransferase--the turning point in polyamine metabolism.

    Robert A. Casero;Anthony E. Pegg

  • Induction of polyamine oxidase 1 by Helicobacter pylori causes macrophage apoptosis by hydrogen peroxide release and mitochondrial membrane depolarization.

    Rupesh Chaturvedi;Yulan Cheng;Mohammad Asim;Françoise I. Bussière

  • Polyamine catabolism and disease.

    Robert A. Casero;Anthony E. Pegg

  • Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

    Yi Huang;Eriko Greene;Tracy Murray Stewart;Andrew C. Goodwin

  • The role of polyamine catabolism in polyamine analogue-induced programmed cell death

    Hyo Chol Ha;Patrick M. Woster;James D. Yager;Robert A. Casero

  • Metabolism links bacterial biofilms and colon carcinogenesis

    Caroline H. Johnson;Christine M. Dejea;David Edler;Linh T. Hoang

  • Spermine and spermidine mediate protection against oxidative damage caused by hydrogen peroxide

    J. E. Rider;J. E. Rider;A. Hacker;C. A. Mackintosh;A. E. Pegg

  • Polyamines and cancer: implications for chemotherapy and chemoprevention

    Shannon L. Nowotarski;Patrick M. Woster;Robert A. Casero

  • Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure.

    Yanlin Wang;Wendy Devereux;Patrick M. Woster;Tracy Murray Stewart

  • Terminally alkylated polyamine analogues as chemotherapeutic agents

    Robert A. Casero;Patrick M. Woster

  • Polyamines differentially modulate the transcription of growth-associated genes in human colon carcinoma cells.

    P Celano;S B Baylin;R A Casero

  • Current Status of the Polyamine Research Field

    Anthony E. Pegg;Robert A. Casero

  • Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes

    Yi Huang;Tracy Murray Stewart;Yu Wu;Stephen B. Baylin

Frequent Co-Authors

Patrick M. Woster
Patrick M. Woster Medical University of South Carolina
Keith T. Wilson
Keith T. Wilson Vanderbilt University Medical Center
Rupesh Chaturvedi
Rupesh Chaturvedi Jawaharlal Nehru University
Stephen B. Baylin
Stephen B. Baylin Johns Hopkins University
Anthony E. Pegg
Anthony E. Pegg Pennsylvania State University
Nancy E. Davidson
Nancy E. Davidson University of Washington
Alain P. Gobert
Alain P. Gobert Vanderbilt University Medical Center
Francis M. Giardiello
Francis M. Giardiello Johns Hopkins University School of Medicine
John L. Cleveland
John L. Cleveland Moffitt Cancer Center

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