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Sophie Janssens

Sophie Janssens

D-Index & Metrics

Biology and Biochemistry

D-Index
49
Citations
12309
World Ranking
17884
National Ranking
297

Overview

Sophie Janssens is affiliated with Ghent University in Belgium and is active in multiple fields within biomedical research. Their work spans notable areas including Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine. The scientist's research focuses extensively on Immunology, Cell Biology, and Molecular Biology as primary subfields, with additional involvement in Surgery and Epidemiology.

Janssens's research topics cover several key domains:

  • Endoplasmic Reticulum Stress and Disease
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Autophagy in Disease and Therapy
  • T-cell and B-cell Immunology
  • IL-33, ST2, and ILC Pathways
  • Immune cells in cancer

The scientist has coauthored with several frequent collaborators including Victor Bosteels, Sofie Rennen, Bart N. Lambrecht, Evelien Van De Velde, and Clint De Nolf. These collaborations are reflected in a diverse set of publications over the years.

Janssens has published in multiple venues, with notable frequency in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • SSRN Electronic Journal
  • The Journal of Experimental Medicine
  • The EMBO Journal
  • EMBO Reports

Key recent papers authored or coauthored by Janssens include:

  • Profiling peripheral nerve macrophages reveals two macrophage subsets with distinct localization, transcriptome and response to injury, 2020, Nature Neuroscience
  • Two distinct ubiquitin-binding motifs in A20 mediate its anti-inflammatory and cell-protective activities, 2020, Nature Immunology
  • TIM3+ TRBV11-2 T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C, 2021, The Journal of Experimental Medicine
  • LXR signaling controls homeostatic dendritic cell maturation, 2023, Science Immunology
  • IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress, 2020, The Journal of Cell Biology

Best Publications

  • Transforming Growth Factor-β1 to the Bone

    Katrien Janssens;Peter ten Dijke;Sophie Janssens;Wim Van Hul

  • Role of Toll-Like Receptors in Pathogen Recognition

    Sophie Janssens;Rudi Beyaert

  • Functional Diversity and Regulation of Different Interleukin-1 Receptor-Associated Kinase (IRAK) Family Members

    Sophie Janssens;Rudi Beyaert

  • Inhibition of Interleukin 1 Receptor/Toll-like Receptor Signaling through the Alternatively Spliced, Short Form of MyD88 Is Due to Its Failure to Recruit IRAK-4

    Kimberly Burns;Sophie Janssens;Brian Brissoni;Natalia Olivos

  • A universal role for MyD88 in TLR/IL-1R-mediated signaling.

    Sophie Janssens;Rudi Beyaert

  • Emerging patterns of cryptic chromosomal imbalance in patients with idiopathic mental retardation and multiple congenital anomalies: a new series of 140 patients and review of published reports

    B. Menten;N. Maas;B. Thienpont;K. Buysse

  • Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8

    Jonathan Maelfait;Elisabeth Vercammen;Sophie Janssens;Peter Schotte

  • PIDD Mediates NF-κB Activation in Response to DNA Damage

    Sophie Janssens;Antoine Tinel;Saskia Lippens;Jürg Tschopp

  • Signals from within: the DNA-damage-induced NF-κB response

    Sophie Janssens;Jürg Tschopp

  • Regulation of Interleukin-1- and Lipopolysaccharide-Induced NF-κB Activation by Alternative Splicing of MyD88

    Sophie Janssens;Kim Burns;Jurg Tschopp;Rudi Beyaert

  • Mitochondrial Priming by CD28

    Ramon I. Klein Geltink;David O’Sullivan;Mauro Corrado;Anna Bremser

  • MyD88S, a splice variant of MyD88, differentially modulates NF-κB- and AP-1-dependent gene expression

    Sophie Janssens;Kim Burns;Elisabeth Vercammen;Jurg Tschopp

  • The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

    Mirjam Kool;Geert van Loo;Wim Waelput;Sofie De Prijck

  • The unfolded-protein-response sensor IRE-1α regulates the function of CD8α⁺ dendritic cells

    Fabiola Osorio;Simon J Tavernier;Eik Hoffmann;Yvan Saeys

  • Emerging functions of the unfolded protein response in immunity

    Sophie Janssens;Bali Pulendran;Bart N Lambrecht

  • The paradox of the unfolded protein response in cancer

    Yves-Paul Vandewynckel;Debby Laukens;Anja Geerts;Eliene Bogaerts

  • Dimethylfumarate is an inhibitor of cytokine-induced E-selectin, VCAM-1, and ICAM-1 expression in human endothelial cells.

    Marc Vandermeeren;Sophie Janssens;Marcel Borgers;Johan Geysen

  • Mitochondria-associated membranes as hubs for neurodegeneration

    Michiel Krols;Gert van Isterdael;Bob Asselbergh;Anna Kremer

  • Autoproteolysis of PIDD marks the bifurcation between pro‐death caspase‐2 and pro‐survival NF‐κB pathway

    Antoine Tinel;Sophie Janssens;Saskia Lippens;Solange Cuenin

  • PIDD Mediates NF-k BA ctivation in Response to DNA Damage

    Sophie Janssens;Antoine Tinel;Saskia Lippens;Jurg Tschopp

Frequent Co-Authors

Bart N. Lambrecht
Bart N. Lambrecht Ghent University
Vincent Timmerman
Vincent Timmerman University of Antwerp
Rudi Beyaert
Rudi Beyaert Ghent University
Riet De Rycke
Riet De Rycke Ghent University
Jürg Tschopp
Jürg Tschopp University of Lausanne
Mathieu J.M. Bertrand
Mathieu J.M. Bertrand Ghent University
Yvan Saeys
Yvan Saeys Ghent University
Wayne I. Lencer
Wayne I. Lencer Harvard University
Hamida Hammad
Hamida Hammad Ghent University
Björn Menten
Björn Menten Ghent University Hospital

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