World's Best Scientists 2026 revealed!

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Biology and Biochemistry

D-Index
79
Citations
20029
World Ranking
4370
National Ranking
2130

Research.com Recognitions

  • 2004 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Wayne I. Lencer is affiliated with Harvard University in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research spans several subfields including molecular biology, immunology, cell biology, surgery, and genetics.

The main topics of Wayne I. Lencer's research include:

  • Lipid Membrane Structure and Behavior
  • Endoplasmic Reticulum Stress and Disease
  • Cellular Transport and Secretion
  • Gut Microbiota and Health
  • Immune Cell Function and Interaction
  • Clostridium difficile and Clostridium perfringens Research
  • Glycosylation and Glycoproteins Research

Frequent coauthors in Wayne I. Lencer's publications are:

  • Jay R. Thiagarajah (16 collaborations)
  • Michael J. Grey (13 collaborations)
  • Stefanie S. Schmieder (10 collaborations)
  • Mariska S. Simpson (8 collaborations)
  • Heidi De Luca (8 collaborations)

The scientist has published numerous articles in various academic venues with notable frequent publication venues including:

  • Gastroenterology (12 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (9 publications)
  • The Journal of Cell Biology (3 publications)
  • The FASEB Journal (3 publications)
  • Proceedings of the National Academy of Sciences (2 publications)

Recent publications by Wayne I. Lencer include the following:

  • Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin, 2020, Proceedings of the National Academy of Sciences
  • Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis, 2021, eLife
  • IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress, 2020, The Journal of Cell Biology
  • The epithelial-specific ER stress sensor ERN2/IRE1β enables host-microbiota crosstalk to affect colon goblet cell development, 2022, Journal of Clinical Investigation
  • Cholera Toxin as a Probe for Membrane Biology, 2021, Toxins

Wayne I. Lencer was recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2004.

Best Publications

  • Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin.

    Billy Tsai;Chiara Rodighiero;Wayne I. Lencer;Tom A. Rapoport

  • Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting.

    A Frey;K T Giannasca;R Weltzin;P J Giannasca

  • Human Neonatal Fc Receptor Mediates Transport of IgG into Luminal Secretions for Delivery of Antigens to Mucosal Dendritic Cells

    Masaru Yoshida;Steven M Claypool;Jessica S Wagner;Emiko Mizoguchi

  • Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure

    Le Shen;Eric D. Black;Edwina D. Witkowski;Wayne I. Lencer

  • Gangliosides are receptors for murine polyoma virus and SV40.

    Billy Tsai;Joanna M. Gilbert;Thilo Stehle;Wayne Lencer

  • Bidirectional FcRn-dependent IgG transport in a polarized human intestinal epithelial cell line

    Bonny L. Dickinson;Kamran Badizadegan;Zhen Wu;Jeremy C. Ahouse

  • Receptor specific transepithelial transport of therapeutics

    Richard S. Blumberg;Neil E. Simister;Wayne I. Lencer

  • Receptor-mediated Immunoglobulin G Transport Across Mucosal Barriers in Adult Life: Functional Expression of FcRn in the Mammalian Lung

    Gerburg M. Spiekermann;Patricia W. Finn;Patricia W. Finn;E. Sally Ward;Jennifer Dumont

  • MHC Class I-Related Neonatal Fc Receptor for IgG Is Functionally Expressed in Monocytes, Intestinal Macrophages, and Dendritic Cells

    Xiaoping Zhu;Gang Meng;Bonny L. Dickinson;Xiaotong Li

  • Pulmonary delivery of an erythropoietin Fc fusion protein in non-human primates through an immunoglobulin transport pathway

    Alan J. Bitonti;Jennifer A. Dumont;Susan C. Low;Robert T. Peters

  • Receptor specific transepithelial transport of immunogens

    Richard S. Blumberg;Neil E. Simister;Wayne I. Lencer

  • The intracellular voyage of cholera toxin: going retro.

    Wayne I. Lencer;Billy Tsai

  • Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation.

    Alan S.L. Yu;Alissa H. Enck;Wayne I. Lencer;Eveline E. Schneeberger

  • The A Adenosine Receptor Mediates cAMP Responses to Adenosine Receptor Agonists in Human Intestinal Epithelia

    Gregg R. Strohmeier;Steven M. Reppert;Wayne I. Lencer;James L. Madara

  • Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER

    Daniel J.-F. Chinnapen;Daniel J.-F. Chinnapen;Himani Chinnapen;David Saslowsky;David Saslowsky;Wayne I. Lencer;Wayne I. Lencer

  • Membrane traffic and the cellular uptake of cholera toxin.

    Wayne I. Lencer;Timothy R. Hirst;Randall K. Holmes

  • Gangliosides That Associate with Lipid Rafts Mediate Transport of Cholera and Related Toxins from the Plasma Membrane to Endoplasmic Reticulm

    Yukako Fujinaga;Anne A. Wolf;Chiara Rodighiero;Heidi Wheeler

  • Ganglioside Structure Dictates Signal Transduction by Cholera Toxin and Association with Caveolae-like Membrane Domains in Polarized Epithelia

    Anne A. Wolf;Michael G. Jobling;Susan Wimer-Mackin;Margaret Ferguson-Maltzman

  • Targeting of cholera toxin and Escherichia coli heat labile toxin in polarized epithelia: role of COOH-terminal KDEL.

    W.I. Lencer;C. Constable;S. Moe;M.G. Jobling

  • Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. Vol. 278 (2003) 17350-17359

    Alan S. Yu;Alissa H. Enck;Wayne I. Lencer;Eveline E. Schneeberger

Frequent Co-Authors

Richard S. Blumberg
Richard S. Blumberg Brigham and Women's Hospital
Seth L. Alper
Seth L. Alper Beth Israel Deaconess Medical Center
Randall K. Holmes
Randall K. Holmes University of Colorado Denver
James L. Madara
James L. Madara American Medical Association
Carlo Brugnara
Carlo Brugnara Boston Children's Hospital
Timothy R. Hirst
Timothy R. Hirst University of Adelaide
Derry C. Roopenian
Derry C. Roopenian The Jackson Laboratory
Edda Fiebiger
Edda Fiebiger Boston Children's Hospital
Alan S. Verkman
Alan S. Verkman University of California, San Francisco
Dennis A. Ausiello
Dennis A. Ausiello Harvard University

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