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2025
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Biology and Biochemistry
USA
2023

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Best Scientists

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176
Citations
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Medicine

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177
Citations
99858
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406
National Ranking
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Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Alan S. Verkman is affiliated with the University of California, San Francisco, in the United States. Their research focuses primarily on medicine, with significant contributions in pulmonary and respiratory medicine, immunology, molecular biology, public health, environmental and occupational health, and neurology.

Their work spans several main topics, including:

  • Cystic fibrosis research advances
  • Neonatal respiratory health research
  • Complement system in diseases
  • Tracheal and airway disorders
  • Ocular surface and contact lens
  • Multiple sclerosis research studies
  • Ion transport and channel regulation

Recent publications illustrate the scope and focus of their research. Selected papers include:

  • "Targeting the complement system in neuromyelitis optica spectrum disorder," 2021, in Expert Opinion on Biological Therapy
  • "Transgenic ferret models define pulmonary ionocyte diversity and function," 2023, in Nature
  • "A small molecule inhibitor of the chloride channel TMEM16A blocks vascular smooth muscle contraction and lowers blood pressure in spontaneously hypertensive rats," 2021, in Kidney International
  • "Emerging therapeutic targets for neuromyelitis optica spectrum disorder," 2020, in Expert Opinion on Therapeutic Targets
  • "A simple method to generate human airway epithelial organoids with externally orientated apical membranes," 2022, in American Journal of Physiology-Lung Cellular and Molecular Physiology

Verkman has collaborated frequently with a group of coauthors, notable among them:

  • Peter M. Haggie
  • Lukmanee Tradtrantip
  • Alexander J. Smith
  • Neel D. Pasricha
  • Nithi Asavapanumas

Their research has been published in a number of specialized venues including:

  • Expert Opinion on Biological Therapy
  • Nature
  • Kidney International
  • Expert Opinion on Therapeutic Targets
  • American Journal of Physiology-Lung Cellular and Molecular Physiology

Among honors, Alan S. Verkman is recognized as a member of the Association of American Physicians.

Best Publications

  • IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.

    Vanda A. Lennon;Thomas J. Kryzer;Sean J. Pittock;A.S. Verkman

  • Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke.

    Geoffrey T. Manley;Miki Fujimura;Tonghui Ma;Nobuo Noshita

  • Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption

    Samira Saadoun;Marios C. Papadopoulos;Mariko Hara-Chikuma;A. S. Verkman

  • Size-dependent DNA Mobility in Cytoplasm and Nucleus

    Gergely L Lukacs;Peter Haggie;Olivier Seksek;Delphine Lechardeur

  • Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema

    Marios C. Papadopoulos;Geoffrey T. Manley;Sanjeev Krishna;A. S. Verkman

  • Structure and function of aquaporin water channels

    A. S. Verkman;Alok K. Mitra

  • Green fluorescent protein as a noninvasive intracellular pH indicator.

    Malea Kneen;Javier Farinas;Yuxin Li;A.S. Verkman

  • Photobleaching recovery and anisotropy decay of green fluorescent protein GFP-S65T in solution and cells: cytoplasmic viscosity probed by green fluorescent protein translational and rotational diffusion.

    R. Swaminathan;C.P. Hoang;A.S. Verkman

  • Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin–induced intestinal fluid secretion

    Tonghui Ma;Jay R. Thiagarajah;Hong Yang;Nitin D. Sonawane

  • More than just water channels: unexpected cellular roles of aquaporins.

    A. S. Verkman

  • Crowding Effects on Diffusion in Solutions and Cells

    James A. Dix;A.S. Verkman

  • Aquaporin water channels in the nervous system

    Marios C. Papadopoulos;Alan S. Verkman

  • Solute and macromolecule diffusion in cellular aqueous compartments

    Alan S Verkman

  • Defective secretion of saliva in transgenic mice lacking aquaporin-5 water channels.

    Tonghui Ma;Yualin Song;Annemarie Gillespie;Elaine J. Carlson

  • Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening

    Nicoletta Pedemonte;Gergely L. Lukacs;Kai Du;Emanuela Caci

  • Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.

    Hajime Hasegawa;Tonghui Ma;William Skach;Michael A. Matthay

  • Aquaporin-4 and brain edema

    Marios C. Papadopoulos;Alan S. Verkman

  • Severely Impaired Urinary Concentrating Ability in Transgenic Mice Lacking Aquaporin-1 Water Channels

    Tonghui Ma;Baoxue Yang;Annemarie Gillespie;Elaine J. Carlson

  • Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4.

    T Ma;B Yang;A Gillespie;E J Carlson

  • Defective proximal tubular fluid reabsorption in transgenic aquaporin-1 null mice

    Jurgen Schnermann;Chung Lin Chou;Tonghui Ma;Timothy Traynor

Frequent Co-Authors

Tonghui Ma
Tonghui Ma Dalian Medical University
Baoxue Yang
Baoxue Yang Peking University
Luis J. V. Galietta
Luis J. V. Galietta Telethon Institute Of Genetics And Medicine
Mark J. Kurth
Mark J. Kurth University of California, Davis
Geoffrey T. Manley
Geoffrey T. Manley University of California, San Francisco
Dennis A. Ausiello
Dennis A. Ausiello Harvard University
Michael A. Matthay
Michael A. Matthay University of California, San Francisco
Dennis Brown
Dennis Brown Harvard University
Walter E. Finkbeiner
Walter E. Finkbeiner University of California, San Francisco
Gergely L. Lukacs
Gergely L. Lukacs McGill University

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