Gergely L. Lukacs

Overview

Best Publications

• Size-dependent DNA Mobility in Cytoplasm and Nucleus

  Gergely L Lukacs;Peter Haggie;Olivier Seksek;Delphine Lechardeur

  959
  Citations

• Metabolic instability of plasmid DNA in the cytosol: a potential barrier to gene transfer.

  Delphine Lechardeur;K. J. Sohn;M. Haardt;P. B. Joshi

  785
  Citations

• Curcumin, a Major Constituent of Turmeric, Corrects Cystic Fibrosis Defects

  Marie E. Egan;Marilyn Pearson;Scott A. Weiner;Vanathy Rajendran

  755
  Citations

• Small-molecule correctors of defective ΔF508-CFTR cellular processing identified by high-throughput screening

  Nicoletta Pedemonte;Gergely L. Lukacs;Kai Du;Emanuela Caci

  668
  Citations

• From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

  Gudio Veit;Radu G. Avramescu;Annette N. Chiang;Scott A. Houck

  559
  Citations

• Conformational maturation of CFTR but not its mutant counterpart (delta F508) occurs in the endoplasmic reticulum and requires ATP.

  Gergely L. Lukacs;Abdalla Mohamed;Norbert Kartner;Xu Bao Chang

  521
  Citations

• Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

  Tsukasa Okiyoneda;Hervé Barrière;Miklós Bagdány;Wael M. Rabeh

  483
  Citations

• Mechanism-based corrector combination restores ΔF508-CFTR folding and function

  Tsukasa Okiyoneda;Guido Veit;Johanna F Dekkers;Miklos Bagdany

  446
  Citations

• The ΔF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR

  Kai Du;Manu Sharma;Gergely L Lukacs

  422
  Citations

• Intracellular routing of plasmid DNA during non-viral gene transfer

  Delphine Lechardeur;A S Verkman;Gergely L Lukacs

  419
  Citations

• CFTR: folding, misfolding and correcting the ΔF508 conformational defect

  Gergely L. Lukacs;A.S. Verkman

  416
  Citations

• Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function

  Wael M. Rabeh;Florian Bossard;Haijin Xu;Tsukasa Okiyoneda

  402
  Citations

• Misfolding diverts CFTR from recycling to degradation quality control at early endosomes

  Manu Sharma;Francesca Pampinella;Csilla Nemes;Mohamed Benharouga

  395
  Citations

• The delta F508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells.

  Gergely L. Lukacs;Xiu Bao Chang;Christine Bear;Norbert Kartner

  362
  Citations

• Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression

  Guido Veit;Radu G. Avramescu;Doranda Perdomo;Puay Wah Phuan

  308
  Citations

• Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

  Darren M Hutt;David Herman;Ana P C Rodrigues;Sabrina Noel

  289
  Citations

• Phagosomal acidification is mediated by a vacuolar-type H(+)-ATPase in murine macrophages.

  G L Lukacs;O D Rotstein;S Grinstein

  287
  Citations

• Intracellular barriers to non-viral gene transfer.

  Delphine Lechardeur;Gergely L Lukacs

  286
  Citations

• C-terminal truncations destabilize the cystic fibrosis transmembrane conductance regulator without impairing its biogenesis. A novel class of mutation.

  Martin Haardt;Mohamed Benharouga;Delphine Lechardeur;Norbert Kartner

  284
  Citations

• Conformational and Temperature-sensitive Stability Defects of the ΔF508 Cystic Fibrosis Transmembrane Conductance Regulator in Post-endoplasmic Reticulum Compartments

  Manu Sharma;Mohamed Benharouga;Wei Hu;Gergely L. Lukacs

  272
  Citations