World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
15900
World Ranking
6410
National Ranking
2994

Overview

Serge Y. Fuchs is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Immunology and Microbiology, Biochemistry, Genetics and Molecular Biology, and Medicine. Within these broad areas, Fuchs focuses on specific subfields including Immunology, Molecular Biology, Oncology, Cancer Research, and Cell Biology.

The main research topics associated with Fuchs include:

  • Immune cells in cancer
  • Interferon and immune responses
  • Immune Cell Function and Interaction
  • CAR-T cell therapy research
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • Ubiquitin and proteasome pathways

Fuchs has contributed to a number of scientific papers published in various respected venues. The most cited recent papers include:

  • A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression (2022, Nature Cell Biology)
  • A small-molecule SUMOylation inhibitor activates antitumor immune responses and potentiates immune therapies in preclinical models (2021, Science Translational Medicine)
  • Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway (2021, Nature Communications)
  • Loss of ELF5-FBXW7 stabilizes IFNGR1 to promote the growth and metastasis of triple-negative breast cancer through interferon-γ signalling (2020, Nature Cell Biology)
  • PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy (2023, Cell Metabolism)

Frequent co-authors who have collaborated extensively with Fuchs include:

  • Constantinos Koumenis
  • J. Alan Diehl
  • Zhen Lu
  • Dmitry I. Gabrilovich
  • Daniel P. Beiting

Common publication venues for Fuchs consist of:

  • Cancer Immunology Research
  • Nature Communications
  • Nature Cell Biology
  • Cell Metabolism
  • Nature Cancer

Fuchs's work extensively involves examining immune interactions within cancer, focusing on the roles of interferon pathways and immune cell modulation. The research addresses mechanisms of cancer progression and resistance, including studies of immune suppressive cells and CAR-T cell therapy resistance. This body of work combines molecular insights with therapeutic implications.

Best Publications

  • Regulation of JNK signaling by GSTp

    Victor Adler;Zhimin Yin;Serge Y. Fuchs;Miriam Benezra

  • UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.

    Oxana A Malakhova;Keun I I Kim;Jiann-Kae Luo;Weiguo Zou

  • Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

    Thomas Buschmann;Olga Potapova;Anat Bar-Shira;Vladimir N. Ivanov

  • The many faces of β -TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer

    Serge Y Fuchs;Vladimir S Spiegelman;K G Suresh Kumar

  • Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex

    Douglas I. Lin;Olena Barbash;K.G. Suresh Kumar;Jason D. Weber

  • ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

    Lori S. Hart;John T. Cunningham;Tatini Datta;Souvik Dey

  • Microbiota-Driven Tonic Interferon Signals in Lung Stromal Cells Protect from Influenza Virus Infection.

    Konrad C. Bradley;Katja Finsterbusch;Daniel Schnepf;Stefania Crotta

  • CRD-BP mediates stabilization of βTrCP1 and c-myc mRNA in response to β-catenin signalling

    Felicite K. Noubissi;Irina Elcheva;Neehar Bhatia;Abbas Shakoori

  • ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

    Souvik Dey;Carly M. Sayers;Ioannis I. Verginadis;Stacey L. Lehman

  • SCFHOS ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-α receptor

    K.G.Suresh Kumar;Weigang Tang;Abhilash K. Ravindranath;William A. Clark

  • DNA damage-induced type I interferon promotes senescence and inhibits stem cell function

    Qiujing Yu;Yuliya V. Katlinskaya;Christopher J. Carbone;Bin Zhao

  • Wnt/β-Catenin Signaling Induces the Expression and Activity of βTrCP Ubiquitin Ligase Receptor

    Vladimir S Spiegelman;Thomas J Slaga;Michele Pagano;Toshinari Minamoto

  • Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment

    Kanstantsin V. Katlinski;Jun Gui;Yuliya V. Katlinskaya;Angelíca Ortiz

  • Associations Among β-TrCP, an E3 Ubiquitin Ligase Receptor, β-Catenin, and NF-κB in Colorectal Cancer

    Andrei Ougolkov;Bin Zhang;Kaname Yamashita;Vladimir Bilim

  • miR-211 Is a Prosurvival MicroRNA that Regulates chop Expression in a PERK-Dependent Manner

    Nilesh S. Chitnis;Dariusz Pytel;Ekaterina Bobrovnikova-Marjon;Dhruv Pant

  • ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.

    Feven Tameire;Ioannis I Verginadis;Nektaria Maria Leli;Christine Polte

  • Elevated expression of Wnt antagonists is a common event in hepatoblastomas.

    Arend Koch;Andreas Waha;Wolfgang Hartmann;Aksana Hrychyk

  • Phosphorylation and specific ubiquitin acceptor sites are required for ubiquitination and degradation of the IFNAR1 subunit of type I interferon receptor.

    K. G. Suresh Kumar;John J. Krolewski;Serge Y. Fuchs

  • Conformation-dependent phosphorylation of p53

    Victor Adler;Matthew R. Pincus;Toshinari Minamoto;Serge Y. Fuchs

  • Virus-Induced Unfolded Protein Response Attenuates Antiviral Defenses via Phosphorylation-Dependent Degradation of the Type I Interferon Receptor

    Jianghuai Liu;Wei Chun HuangFu;K. G Suresh Kumar;Juan Qian

Frequent Co-Authors

J. Alan Diehl
J. Alan Diehl Case Western Reserve University
Constantinos Koumenis
Constantinos Koumenis University of Pennsylvania
Hallgeir Rui
Hallgeir Rui Medical College of Wisconsin
Davide Ruggero
Davide Ruggero University of California, San Francisco
Stuart J. Frank
Stuart J. Frank University of Alabama at Birmingham
Ze'ev Ronai
Ze'ev Ronai Cedars-Sinai Medical Center
Anil K. Rustgi
Anil K. Rustgi Columbia University
Sandra Pellegrini
Sandra Pellegrini Institut Pasteur
Narayan G. Avadhani
Narayan G. Avadhani University of Pennsylvania

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