World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
85
Citations
33041
World Ranking
1303
National Ranking
49

Medicine

D-Index
85
Citations
33207
World Ranking
14445
National Ranking
478

Overview

Paul J. Hertzog is affiliated with the Hudson Institute of Medical Research in Australia. Their body of work primarily spans the fields of Immunology and Microbiology as well as Medicine, with a focus on several subfields including Immunology, Oncology, Pulmonary and Respiratory Medicine, Infectious Diseases, and Molecular Biology.

The research topics covered by Paul J. Hertzog include:

  • Immune Cell Function and Interaction
  • Interferon and Immune Responses
  • T-cell and B-cell Immunology
  • Cytokine Signaling Pathways and Interactions
  • Immunotherapy and Immune Responses
  • Immune Cells in Cancer
  • Immune Response and Inflammation

Their recent published papers demonstrate a wide scope of study within these domains. Notable publications include:

  • "Mitochondrial arginase-2 is essential for IL-10 metabolic reprogramming of inflammatory macrophages," 2021, Nature Communications
  • "Prostate cancer cell-intrinsic interferon signaling regulates dormancy and metastatic outgrowth in bone," 2020, EMBO Reports
  • "Interferon-ε is a tumour suppressor and restricts ovarian cancer," 2023, Nature
  • "Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses," 2021, Journal of Extracellular Vesicles
  • "Increased SARS-CoV-2 Infection, Protease, and Inflammatory Responses in Chronic Obstructive Pulmonary Disease Primary Bronchial Epithelial Cells Defined with Single-Cell RNA Sequencing," 2022, American Journal of Respiratory and Critical Care Medicine

Paul J. Hertzog has collaborated frequently with several co-authors, with the most frequent including:

  • Linden J. Gearing
  • Nicole A. de Weerd
  • Antony Y. Matthews
  • Michelle D. Tate
  • San Sui Lim

Their work has appeared in multiple venues, most commonly:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • PLoS Pathogens
  • SSRN Electronic Journal
  • Cell Reports

Best Publications

  • Interferon-γ: an overview of signals, mechanisms and functions

    Kate Schroder;Paul John Hertzog;Timothy Ravasi;David A Hume

  • INTERFEROME v2.0: an updated database of annotated interferon-regulated genes

    Irina Rusinova;Samuel Forster;Simon Xiaoming Yu;Anitha Kannan

  • SOCS1 Is a Critical Inhibitor of Interferon γ Signaling and Prevents the Potentially Fatal Neonatal Actions of this Cytokine

    Warren S Alexander;Robyn Starr;Robyn Starr;Jennifer E Fenner;Clare L Scott;Clare L Scott

  • Antitumour actions of interferons: implications for cancer therapy

    Belinda S. Parker;Jai Rautela;Jai Rautela;Jai Rautela;Paul J. Hertzog

  • Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells

    Thomas Luft;Ken C Pang;Elisabeth Thomas;Paul J Hertzog

  • Differential production of IL-12, IFN-alpha, and IFN-gamma by mouse dendritic cell subsets.

    Hubertus Hochrein;Ken Shortman;David Vremec;Bernadette M Scott

  • Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

    Ashley Scott Mansell;Rosealee Anne Smith;Sarah L Doyle;Pearl Gray

  • Mice with a Homozygous Null Mutation for the Most Abundant Glutathione Peroxidase, Gpx1, Show Increased Susceptibility to the Oxidative Stress-inducing Agents Paraquat and Hydrogen Peroxide

    Judy Bettina De Haan;Cecile Bladier;Peter Griffiths;Michael J Kelner

  • Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization.

    Maxine Gowen;Francesca Lazner;Robert Dodds;Rasesh Kapadia

  • The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

    Elizabeth C. Carroll;Lei Jin;Andres Mori;Natalia Muñoz-Wolf

  • Mouse Plasmacytoid Cells Long-lived Cells, Heterogeneous in Surface Phenotype and Function, that Differentiate Into CD8+ Dendritic Cells Only after Microbial Stimulus

    Meredith O’Keeffe;Hubertus Hochrein;David Vremec;Irina Caminschi

  • A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses

    Seung Y. Hwang;Paul J. Hertzog;Kerry A. Holland;Sony H. Sumarsono

  • Type I Interferon Receptors: Biochemistry and Biological Functions

    Nicole Anne De Weerd;Shamith Samarajiwa;Paul John Hertzog

  • Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape

    Bradley N Bidwell;Bradley N Bidwell;Clare Y Slaney;Clare Y Slaney;Nimali P Withana;Nimali P Withana;Sam Forster

  • Analysis of microRNA turnover in mammalian cells following Dicer1 ablation

    Michael P. Gantier;Claire E. McCoy;Irina Rusinova;Damien Saulep

  • Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells

    Maria Kaparakis;Lynne Turnbull;Leticia Carneiro;Stephen Firth

  • STAT3 and STAT1 mediate IL-11–dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

    Matthias Ernst;Meri Najdovska;Dianne Grail;Therese Lundgren-May

  • Type I IFN contributes to NK cell homeostasis, activation, and antitumor function.

    Jeremy B Swann;Yashihiro Hayakawa;Nadeen Zerafa;Kathleen Cf Sheehan

  • IFNβ-dependent increases in STAT1, STAT2, and IRF9 mediate resistance to viruses and DNA damage.

    HyeonJoo Cheon;Elise Holvey-Bates;John W Schoggins;Samuel Forster

  • GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

    Andrew J Fleetwood;Andrew J Fleetwood;Hang Dinh;Hang Dinh;Andrew D Cook;Andrew D Cook;Paul John Hertzog;Paul John Hertzog

  • Suppressor of cytokine signaling 1 regulates the immune response to infection by a unique inhibition of type I interferon activity

    Jennifer Eve Fenner;Robyn J Starr;Ann L Cornish;Ann L Cornish;Jian-Guo Zhang

Frequent Co-Authors

Ismail Kola
Ismail Kola MSD (United States)
Ashley Mansell
Ashley Mansell Hudson Institute of Medical Research
Anthony W. Linnane
Anthony W. Linnane Monash University
Jamie Rossjohn
Jamie Rossjohn Monash University
John A. Hamilton
John A. Hamilton University of Melbourne
Brendan J. Jenkins
Brendan J. Jenkins Hudson Institute of Medical Research
Ernst J. Wolvetang
Ernst J. Wolvetang University of Queensland
Robin L. Anderson
Robin L. Anderson La Trobe University
Johnson Mak
Johnson Mak Griffith University
Meredith O'Keeffe
Meredith O'Keeffe Monash University

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