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Biology and Biochemistry

D-Index
69
Citations
25156
World Ranking
7259
National Ranking
3333

Overview

Constantinos Koumenis is affiliated with the University of Pennsylvania in the United States. Their research spans multiple interconnected fields primarily within medicine, focusing on oncological and molecular biological applications. Their work addresses specific domains such as oncology, pulmonary and respiratory medicine, molecular biology, radiology, nuclear medicine, imaging, and radiation therapy.

The scientist's research interests concentrate on advanced topics including radiation therapy and dosimetry, advanced radiotherapy techniques, CAR-T cell therapy research, effects of radiation exposure, radiomics and machine learning in medical imaging, cancer immunotherapy and biomarkers, and glioma diagnosis and treatment.

Constantinos Koumenis has contributed to various reputable scientific journals. They have published extensively in venues including Cancer Research, International Journal of Radiation Oncology*Biology*Physics, Physica Medica, Radiotherapy and Oncology, and bioRxiv (Cold Spring Harbor Laboratory).

Frequent collaborators in their research include Ioannis I. Verginadis, Eric S. Diffenderfer, Michele M. Kim, Keith A. Cengel, and Amit Maity. These partnerships have contributed to a range of studies in radiation therapy and cancer biology.

Notable publications by Constantinos Koumenis include:

  • Design, Implementation, and in Vivo Validation of a Novel Proton FLASH Radiation Therapy System, 2020, International Journal of Radiation Oncology*Biology*Physics
  • FLASH Proton Radiotherapy Spares Normal Epithelial and Mesenchymal Tissues While Preserving Sarcoma Response, 2021, Cancer Research
  • A stromal Integrated Stress Response activates perivascular cancer-associated fibroblasts to drive angiogenesis and tumour progression, 2022, Nature Cell Biology
  • Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma, 2020, Science Translational Medicine
  • Comparison of FLASH Proton Entrance and the Spread-Out Bragg Peak Dose Regions in the Sparing of Mouse Intestinal Crypts and in a Pancreatic Tumor Model, 2021, Cancers

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

    Meixia Bi;Christine Naczki;Marianne Koritzinsky;Diane Fels

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • REGULATION OF PROTEIN SYNTHESIS BY HYPOXIA VIA ACTIVATION OF THE ENDOPLASMIC RETICULUM KINASE PERK AND PHOSPHORYLATION OF THE TRANSLATION INITIATION FACTOR EIF2ALPHA

    Constantinos Koumenis;Christine Naczki;Marianne Koritzinsky;Sally Rastani

  • The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

    Jiangbin Ye;Monika Kumanova;Lori S Hart;Kelly Sloane

  • The PERK/eIF2alpha/ATF4 module of the UPR in hypoxia resistance and tumor growth.

    Diane R. Fels;Constantinos Koumenis

  • Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

    Constantinos Koumenis;Rodolfo Alarcon;Ester Hammond;Patrick Sutphin

  • Targeting ER stress–induced autophagy overcomes BRAF inhibitor resistance in melanoma

    Xiao Hong Ma;Sheng Fu Piao;Souvik Dey;Quentin McAfee

  • ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

    Lori S. Hart;John T. Cunningham;Tatini Datta;Souvik Dey

  • Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control

    Marianne Koritzinsky;Michaël G Magagnin;Twan van den Beucken;Renaud Seigneuric

  • PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

    E Bobrovnikova-Marjon;C Grigoriadou;D Pytel;F Zhang

  • ER Stress, Hypoxia Tolerance and Tumor Progression

    Constantinos Koumenis

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • “Translating” Tumor Hypoxia: Unfolded Protein Response (UPR)–Dependent and UPR-Independent Pathways

    Constantinos Koumenis;Bradly G. Wouters

  • ATF4-dependent induction of heme oxygenase 1 prevents anoikis and promotes metastasis

    Souvik Dey;Carly M. Sayers;Ioannis I. Verginadis;Stacey L. Lehman

  • GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2

    Jiangbin Ye;Wilhelm Palm;Min Peng;Bryan King

  • Effects of Radiation Quality and Oxygen on Clustered DNA Lesions and Cell Death

    Robert D. Stewart;Victor K. Yu;Alexandros G. Georgakilas;Constantinos Koumenis

  • Inactivation of Interferon Receptor Promotes the Establishment of Immune Privileged Tumor Microenvironment

    Kanstantsin V. Katlinski;Jun Gui;Yuliya V. Katlinskaya;Angelíca Ortiz

  • Gut microbiota modulate dendritic cell antigen presentation and radiotherapy-induced antitumor immune response

    Mireia Uribe-Herranz;Stavros Rafail;Silvia Beghi;Luis Gil-de-Gómez

  • miR-211 Is a Prosurvival MicroRNA that Regulates chop Expression in a PERK-Dependent Manner

    Nilesh S. Chitnis;Dariusz Pytel;Ekaterina Bobrovnikova-Marjon;Dhruv Pant

Frequent Co-Authors

Serge Y. Fuchs
Serge Y. Fuchs University of Pennsylvania
J. Alan Diehl
J. Alan Diehl Case Western Reserve University
Amato J. Giaccia
Amato J. Giaccia Stanford University
Albert C. Koong
Albert C. Koong The University of Texas MD Anderson Cancer Center
Davide Ruggero
Davide Ruggero University of California, San Francisco
Ian G. Mills
Ian G. Mills University of Oxford
Bradly G. Wouters
Bradly G. Wouters Princess Margaret Cancer Centre
Evelina Gatti
Evelina Gatti Aix-Marseille University
Lin Zhang
Lin Zhang University of Pennsylvania
Ester M. Hammond
Ester M. Hammond University of Oxford

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