World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
71
Citations
38382
World Ranking
6493
National Ranking
3023

Overview

Lin Zhang is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of biochemistry, genetics, and molecular biology, with a significant emphasis on medicine and immunology and microbiology. Over their career, they have contributed extensively to molecular biology and cancer research, focusing on immunology, oncology, and genetics as notable subfields.

The scientist's main research topics include immune cells in cancer, single-cell and spatial transcriptomics, cancer genomics and diagnostics, cancer immunotherapy and biomarkers, immune cell function and interaction, viral infectious diseases and gene expression in insects, and mesenchymal stem cell research.

Lin Zhang has published numerous papers in several scientific venues. Frequent publication platforms include bioRxiv (Cold Spring Harbor Laboratory) with 11 papers, Nature Communications with 6 publications, SSRN Electronic Journal also featuring 6 works, Frontiers in Immunology with 5 papers, and PubMed with 4 contributions.

Some of the recent published works connected to the scientist's area of study include:

  • Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes (2020, Nature Communications)
  • Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells (2020, Cell Metabolism)
  • Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40 (2021, Nature Communications)
  • Wnt-mediated endothelial transformation into mesenchymal stem cell-like cells induces chemoresistance in glioblastoma (2020, Science Translational Medicine)
  • The Cancer Surfaceome Atlas integrates genomic, functional and drug response data to identify actionable targets (2021, Nature Cancer)

The scientist often collaborates with colleagues who have worked extensively alongside them. Frequent co-authors include Zhongyi Hu, Yi Fan, Duo Zhang, Yanqing Gong, and Youyou Zhang, all of whom have multiple joint publications with Lin Zhang.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival.

    Tyler J Curiel;George Coukos;Linhua Zou;Xavier Alvarez

  • Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer.

    Lin Zhang;Jose R. Conejo-Garcia;Dionyssios Katsaros;Phyllis A. Gimotty

  • Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T reg cells

    Andrea Facciabene;Xiaohui Peng;Ian S. Hagemann;Klara Balint

  • microRNAs exhibit high frequency genomic alterations in human cancer

    Lin Zhang;Jia Huang;Nuo Yang;Joel Greshock

  • The microRNAs miR-373 and miR-520c promote tumour invasion and metastasis

    Huang Q;Gumireddy K;Schrier M;le Sage C

  • Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

    Denarda Dangaj;Marine Bruand;Alizée J. Grimm;Catherine Ronet

  • Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer

    Lin Zhang;Stefano Volinia;Tomas Bonome;George Adrian Calin

  • Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers

    Xiaohui Yan;Xiaohui Yan;Zhongyi Hu;Yi Feng;Xiaowen Hu

  • Tumor-infiltrating dendritic cell precursors recruited by a beta-defensin contribute to vasculogenesis under the influence of Vegf-A.

    Jose R. Conejo-Garcia;Fabian Benencia;Maria Cecilia Courreges;Eugene Kang

  • Distinct Expression Levels and Patterns of Stem Cell Marker, Aldehyde Dehydrogenase Isoform 1 (ALDH1), in Human Epithelial Cancers

    Shan Deng;Shan Deng;Xiaojun Yang;Xiaojun Yang;Heini Lassus;Shun-Zhi Liang

  • MicroRNA Microarray Identifies Let-7i as a Novel Biomarker and Therapeutic Target in Human Epithelial Ovarian Cancer

    Nuo Yang;Sippy Kaur;Stefano Volinia;Joel Greshock

  • miR-210 Links Hypoxia with Cell Cycle Regulation and Is Deleted in Human Epithelial Ovarian Cancer

    Antonis Giannakakis;Raphael Sandaltzopoulos;Joel Greshock;Shun Liang

  • Mechanisms of microRNA deregulation in human cancer.

    Shan Deng;George Adrian Calin;Carlo M. Croce;George Coukos

  • A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer

    Xiaowen Hu;Yi Feng;Dongmei Zhang;Dongmei Zhang;Sihai D. Zhao

  • Tumor-derived Vascular Endothelial Growth Factor Up-Regulates Angiopoietin-2 in Host Endothelium and Destabilizes Host Vasculature, Supporting Angiogenesis in Ovarian Cancer

    Lin Zhang;Nuo Yang;Jin-Wan Park;Dionyssios Katsaros

  • Integrated proteogenomic deep sequencing and analytics accurately identify non-canonical peptides in tumor immunopeptidomes.

    Chloe Chong;Chloe Chong;Markus Müller;HuiSong Pak;HuiSong Pak;Dermot Harnett

  • Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

    Youyou Zhang;Qun He;Zhongyi Hu;Yi Feng

  • Vector-based RNAi, a novel tool for isoform-specific knock-down of VEGF and anti-angiogenesis gene therapy of cancer.

    Lin Zhang;Nuo Yang;Alisha Mohamed-Hadley;Stephen C Rubin

  • Therapeutic MicroRNA Strategies in Human Cancer

    Chunsheng Li;Yi Feng;George Coukos;Lin Zhang

Frequent Co-Authors

George Coukos
George Coukos Cornell University
Dionyssios Katsaros
Dionyssios Katsaros University of Turin
Phyllis A. Gimotty
Phyllis A. Gimotty University of Pennsylvania
Barbara L. Weber
Barbara L. Weber Tango Therapeutics
Jose R. Conejo-Garcia
Jose R. Conejo-Garcia Duke University
Stephen C. Rubin
Stephen C. Rubin University of Pennsylvania
Anil K. Sood
Anil K. Sood The University of Texas MD Anderson Cancer Center
Chi V. Dang
Chi V. Dang University of Pennsylvania
Andrew V. Kossenkov
Andrew V. Kossenkov The Wistar Institute
Xiaowei Xu
Xiaowei Xu University of Pennsylvania

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