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Immunology

D-Index
66
Citations
18261
World Ranking
2737
National Ranking
1305

Overview

Daniel J. Powell is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Medicine and Immunology and Microbiology, with a significant focus on Immunology and Oncology as key subfields. Molecular Biology, Reproductive Medicine, and Radiology, Nuclear Medicine and Imaging also feature among their research interests.

Their main research topics include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Cancer Immunotherapy and Biomarkers
  • Ovarian cancer diagnosis and treatment
  • Immune cells in cancer
  • Viral Infectious Diseases and Gene Expression in Insects

Powell has contributed extensively to the scientific literature, with notable recent papers including:

  • Randomized Phase II Trial of Nivolumab Versus Nivolumab and Ipilimumab for Recurrent or Persistent Ovarian Cancer: An NRG Oncology Study, 2020, Journal of Clinical Oncology
  • CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape, 2020, Frontiers in Immunology
  • CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy, 2021, Nature Communications
  • Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation, 2021, Cancer Cell
  • NKG2D-CAR-transduced natural killer cells efficiently target multiple myeloma, 2021, Blood Cancer Journal

Their frequent co-authors include:

  • Sarah B. Gitto
  • Mathilde Poussin
  • Monika A. Eiva
  • Alba Rodríguez-García
  • Fiona Simpkins

Powell's work is often published in several leading venues, notably:

  • Cancer Research
  • Regular and Young Investigator Award Abstracts
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cancer Cell
  • Nature Cancer

Best Publications

  • Adoptive immunotherapy for cancer: building on success.

    Luca Gattinoni;Daniel J. Powell;Steven A. Rosenberg;Nicholas P. Restifo

  • Rethinking ovarian cancer II: Reducing mortality from high-grade serous ovarian cancer

    David D. Bowtell;David D. Bowtell;Steffen Böhm;Ahmed A. Ahmed;Paul Joseph Aspuria

  • Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

    Denarda Dangaj;Marine Bruand;Alizée J. Grimm;Catherine Ronet

  • Cutting Edge: Persistence of Transferred Lymphocyte Clonotypes Correlates with Cancer Regression in Patients Receiving Cell Transfer Therapy

    Paul F. Robbins;Mark E. Dudley;John Wunderlich;Mona El-Gamil

  • Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T Cells Expressing a Mesothelin - Specific Chimeric Antibody Receptor

    Edmund K. Moon;Carmine Carpenito;Jing Sun;Liang-Chuan S. Wang

  • Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

    Janos L. Tanyi;Sara Bobisse;Eran Ophir;Sandra Tuyaerts

  • Transition of late-stage effector T cells to CD27+ CD28+ tumor-reactive effector memory T cells in humans after adoptive cell transfer therapy

    Daniel J. Powell;Mark E. Dudley;Paul F. Robbins;Steven A. Rosenberg

  • CD27 costimulation augments the survival and antitumor activity of redirected human T cells in vivo.

    De Gang Song;De Gang Song;Qunrui Ye;Mathilde Poussin;Gretchen M. Harms

  • Gene Transfer of Tumor-Reactive TCR Confers Both High Avidity and Tumor Reactivity to Nonreactive Peripheral Blood Mononuclear Cells and Tumor-Infiltrating Lymphocytes

    Laura A. Johnson;Bianca Heemskerk;Daniel J. Powell;Cyrille J. Cohen

  • Chimeric antigen receptor T Cells with dissociated signaling domains exhibit focused antitumor activity with reduced potential for toxicity in vivo.

    Evripidis Lanitis;Mathilde Poussin;Alex W. Klattenhoff;Degang Song

  • In Vivo Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)

    De Gang Song;Qunrui Ye;Carmine Carpenito;Mathilde Poussin

  • Tumor infiltrating lymphocytes in ovarian cancer

    Phillip P Santoiemma;Daniel J Powell

  • CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

    Andrew J. Rech;Rosemarie Mick;Sunil Martin;Adri Recio

  • A Universal Strategy for Adoptive Immunotherapy of Cancer through Use of a Novel T-cell Antigen Receptor

    Katarzyna Urbanska;Evripidis Lanitis;Mathilde Poussin;Rachel C. Lynn

  • CD137 Accurately Identifies and Enriches for Naturally Occurring Tumor-Reactive T Cells in Tumor

    Qunrui Ye;De-Gang Song;Mathilde Poussin;Tori Yamamoto

  • Randomized Phase II Trial of Nivolumab Versus Nivolumab and Ipilimumab for Recurrent or Persistent Ovarian Cancer: An NRG Oncology Study

    Dmitriy Zamarin;Robert A. Burger;Michael W. Sill;Daniel J. Powell

  • The RET/PTC3 oncogene : Metastatic solid-type papillary carcinomas in murine thyroids

    Daniel J. Powell;John Russell;Ken-ichi Nibu;Guoqi Li

  • CAR-T Cells Hit the Tumor Microenvironment: Strategies to Overcome Tumor Escape.

    Alba Rodriguez-Garcia;Asis Palazon;Estela Noguera-Ortega;Daniel J. Powell

  • CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy.

    Alba Rodriguez-Garcia;Rachel C. Lynn;Mathilde Poussin;Monika A. Eiva

  • A Dendritic Cell Vaccine Pulsed with Autologous Hypochlorous Acid-Oxidized Ovarian Cancer Lysate Primes Effective Broad Antitumor Immunity: From Bench to Bedside

    Cheryl Lai-Lai Chiang;Lana E. Kandalaft;Janos Tanyi;Andrea R. Hagemann

  • Redirected Antitumor Activity of Primary Human Lymphocytes Transduced With a Fully Human Anti-mesothelin Chimeric Receptor

    Evripidis Lanitis;Mathilde Poussin;Ian S Hagemann;George Coukos

Frequent Co-Authors

George Coukos
George Coukos Cornell University
Lana E. Kandalaft
Lana E. Kandalaft Ludwig Cancer Research
Carl H. June
Carl H. June University of Pennsylvania
Steven A. Rosenberg
Steven A. Rosenberg National Institutes of Health
Bruce L. Levine
Bruce L. Levine University of Pennsylvania
Rosemarie Mick
Rosemarie Mick University of Pennsylvania
Michael C. Milone
Michael C. Milone University of Pennsylvania
Nicholas P. Restifo
Nicholas P. Restifo National Institutes of Health
Mark E. Dudley
Mark E. Dudley Novartis (Switzerland)
Philip D. Greenberg
Philip D. Greenberg Fred Hutchinson Cancer Research Center

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