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Chemistry

D-Index
45
Citations
5908
World Ranking
16604
National Ranking
4121

Overview

Jeffrey P. Jones is affiliated with Washington State University in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with specific contributions covering Molecular Biology, Pharmacology, Ophthalmology, Pathology and Forensic Medicine, and Neurology. The scientist's work spans several main topics, including Retinoids in leukemia and cellular processes, Peroxisome Proliferator-Activated Receptors, Retinal Diseases and Treatments, Alcohol Consumption and Health Effects, Microbial metabolism and enzyme function, Neurological diseases and metabolism, and Pharmacogenetics and Drug Metabolism.

The scientist has authored several papers in various research venues. Among recent publications are:

  • Aldehyde Oxidase Contributes to All-Trans-Retinoic Acid Biosynthesis in Human Liver (2020, Drug Metabolism and Disposition)
  • Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey (2020, Drug Metabolism and Disposition)
  • A9 - Aldehyde oxidase contributes to all-trans-retinoic acid biosynthesis in human liver (2020, Drug Metabolism and Pharmacokinetics)
  • 3D Kinetic Analysis: A Rapid, Model Independent, Method for Enzyme Kinetics (2021, Research Square (Research Square))

Jeffrey P. Jones often collaborates with several frequent co-authors, including Erickson M. Paragas, Ethan Thompson, Guo Zhong, Chris J. Seaman, and Huaqing Xi. These partnerships have contributed to multiple research outputs.

The scientist's publications are predominantly found in journals such as:

  • Drug Metabolism and Disposition
  • Drug Metabolism and Pharmacokinetics
  • Research Square (Research Square)

In addition to journal articles, Jeffrey P. Jones has contributed to the book publication "Satire TV" released by New York University Press eBooks in 2020.

Best Publications

  • Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions

    Jeanette Beers;Daniel R Gulbranson;Daniel R Gulbranson;Nicole George;Lauren I Siniscalchi

  • CLINICAL AND TOXICOLOGICAL RELEVANCE OF CYP2C9: Drug-Drug Interactions and Pharmacogenetics

    Allan E. Rettie;Jeffrey P. Jones

  • Pharmacophore and three-dimensional quantitative structure activity relationship methods for modeling cytochrome p450 active sites.

    Sean Ekins;Marcel J. de Groot;Jeffrey P. Jones

  • An in Vivo Pilot Study Characterizing the New CYP2A6*7, *8, and *10 Alleles

    C. Xu;Y.S. Rao;Y.S. Rao;B. Xu;B. Xu;E. Hoffmann;E. Hoffmann

  • Mechanism of Oxidative Amine Dealkylation of Substituted N,N-Dimethylanilines by Cytochrome P-450: Application of Isotope Effect Profiles

    S. B. Karki;J. P. Dinnocenzo;J. P. Jones;K. R. Korzekwa

  • Alternative splicing determines the function of CYP4F3 by switching substrate specificity.

    Peter Christmas;Jeffrey P. Jones;Christopher J. Patten;Dan A. Rock

  • Generation of serotonin neurons from human pluripotent stem cells

    Jianfeng Lu;Xuefei Zhong;Huisheng Liu;Ling Hao

  • A New Mechanistic Probe for Cytochrome P450: An Application of Isotope Effect Profiles

    John I. Manchester;Joseph P. Dinnocenzo;LeeAnn Higgins;Jeffrey P. Jones

  • Computational models for cytochrome P450: a predictive electronic model for aromatic oxidation and hydrogen atom abstraction.

    Jeffrey P. Jones;Michael Mysinger;Kenneth Ray Korzekwa

  • Three-dimensional quantitative structure-activity relationship for inhibitors of cytochrome P4502C9.

    Jeffrey P. Jones;Minxia He;William F. Trager;Allan E. Rettie

  • A Refined 3-Dimensional QSAR of Cytochrome P450 2C9: Computational Predictions of Drug Interactions

    Sreedhara Rao;Ron Aoyama;Michael Schrag;William F. Trager

  • Flavone antagonists bind competitively with 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) to the aryl hydrocarbon receptor but inhibit nuclear uptake and transformation.

    Ellen C. Henry;Andrew S. Kende;George Rucci;Michael J. Totleben

  • Electron Spin Resonance Studies of Doped Synthetic Kaolinite. I

    B. R. Angel;J. P. E. Jones;Peter L. Hall

  • The Impact of Single Nucleotide Polymorphisms on Human Aldehyde Oxidase

    Tobias Hartmann;Mineko Terao;Enrico Garattini;Christian Teutloff

  • Enzymatic Determinants of the Substrate Specificity of CYP2C9: Role of B‘−C Loop Residues in Providing the π-Stacking Anchor Site for Warfarin Binding†

    Robert L. Haining;Jeffrey P. Jones;Kirk R. Henne;Michael B. Fisher

  • On isotope effects for the cytochrome P-450 oxidation of substituted N,N-dimethylanilines

    J. P. Dinnocenzo;S. B. Karki;J. P. Jones

  • Structural forms of phenprocoumon and warfarin that are metabolized at the active site of CYP2C9.

    Minxia He;Kenneth R. Korzekwa;Jeffrey P. Jones;Allan E. Rettie

  • Evidence for two different active oxygen species in cytochrome P450 BM3 mediated sulfoxidation and N-dealkylation reactions.

    Trent J. Volz;Denise A. Rock;Jeffrey P. Jones

  • Identification of novel substrates for human cytochrome P450 2J2.

    Caroline A. Lee;David Neul;Andrea Clouser-Roche;Deepak Dalvie

  • Identifying a Selective Substrate and Inhibitor Pair for the Evaluation of CYP2J2 Activity

    Caroline A. Lee;J. P. Jones;Jonathan Katayama;Rüdiger Kaspera

  • Isotopically sensitive branching and its effect on the observed intramolecular isotope effects in cytochrome P-450 catalyzed reactions: a new method for the estimation of intrinsic isotope effects

    Jeffrey P. Jones;Kenneth R. Korzekwa;Allan E. Rettie;William F. Trager

  • Mechanisms of N-Demethylations Catalyzed by High-Valent Species of Heme Enzymes: Novel Use of Isotope Effects and Direct Observation of Intermediates

    Yoshio Goto;Yoshihito Watanabe;Shunichi Fukuzumi;Jeffrey P. Jones

  • Studies on the mechanism of aldehyde oxidase and xanthine oxidase.

    Joshua F. Alfaro;Jeffrey P. Jones

  • Designing safer chemicals: Predicting the rates of metabolism of halogenated alkanes

    Hequn Yin;M. W. Anders;Kenneth R. Korzekwa;Lee Ann Higgins

  • Use of Density Functional Calculations To Predict the Regioselectivity of Drugs and Molecules Metabolized by Aldehyde Oxidase

    Rhonda A. Torres;Kenneth R. Korzekwa;Daniel R. McMasters;Christine M. Fandozzi

  • Kinetic isotope effects implicate the iron-oxene as the sole oxidant in P450-catalyzed N-dealkylation.

    Tamara S. Dowers;Dan A. Rock;Denise A. Rock;Jeffrey P. Jones

Frequent Co-Authors

William F. Trager
William F. Trager University of Washington
Allan E. Rettie
Allan E. Rettie University of Washington
M. W. Anders
M. W. Anders University of Rochester Medical Center
Gerald Schatten
Gerald Schatten University of Pittsburgh
Silke Leimkühler
Silke Leimkühler University of Potsdam
Kenneth E. Thummel
Kenneth E. Thummel University of Washington
James A. Thomson
James A. Thomson University of California, Santa Barbara
Enrico Garattini
Enrico Garattini Mario Negri Institute for Pharmacological Research
Scott E. Sattler
Scott E. Sattler Agricultural Research Service
Michal Otyepka
Michal Otyepka Palacký University, Olomouc

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