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Immunology

D-Index
59
Citations
28343
World Ranking
3373
National Ranking
1557

Overview

Christopher A. Klebanoff is affiliated with Memorial Sloan Kettering Cancer Center in the United States. Their research primarily focuses on the fields of Medicine, Immunology and Microbiology, and Biochemistry, Genetics and Molecular Biology.

The subfields of study within their work include Oncology, Immunology, Molecular Biology, Radiology, Nuclear Medicine and Imaging, and Genetics.

Research topics frequently addressed by Klebanoff encompass CAR-T cell therapy research, Immunotherapy and Immune Responses, Cancer Immunotherapy and Biomarkers, Immune Cell Function and Interaction, Monoclonal and Polyclonal Antibodies Research, T-cell and B-cell Immunology, and Virus-based gene therapy research.

The scientist has authored numerous papers, including:

  • Clinical implications of T cell exhaustion for cancer immunotherapy, 2022, Nature Reviews Clinical Oncology
  • T cell receptor therapeutics: immunological targeting of the intracellular cancer proteome, 2023, Nature Reviews Drug Discovery
  • Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA, 2022, Nature Medicine
  • The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer, 2022, Immunity
  • Immunomodulatory Activity of a Colony-stimulating Factor-1 Receptor Inhibitor in Patients with Advanced Refractory Breast or Prostate Cancer: A Phase I Study, 2020, Clinical Cancer Research

Klebanoff frequently collaborates with several authors including Smita S. Chandran, Iñaki Etxeberría, Michael V. Gormally, Darwin Kwok, and Nicholas Stevers.

The scientist has published extensively in a variety of venues, notably Cancer Research, bioRxiv (Cold Spring Harbor Laboratory), Regular and Young Investigator Award Abstracts, Cancer Immunology Research, and Journal of Clinical Oncology.

Best Publications

  • Tumor mutational load predicts survival after immunotherapy across multiple cancer types.

    Robert M Samstein;Chung-Han Lee;Chung-Han Lee;Alexander N Shoushtari;Alexander N Shoushtari;Matthew D Hellmann;Matthew D Hellmann

  • Removal of homeostatic cytokine sinks by lymphodepletion enhances the efficacy of adoptively transferred tumor-specific CD8+ T cells

    Luca Gattinoni;Steven E. Finkelstein;Christopher A. Klebanoff;Christopher A. Klebanoff;Paul A. Antony

  • Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells

    Christopher A. Klebanoff;Luca Gattinoni;Parizad Torabi-Parizi;Keith Kerstann

  • Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells

    Luca Gattinoni;Christopher A. Klebanoff;Christopher A. Klebanoff;Douglas C. Palmer;Claudia Wrzesinski

  • Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells

    Willem W. Overwijk;Marc R. Theoret;Steven E. Finkelstein;Deborah R. Surman

  • TOX is a critical regulator of tumour-specific T cell differentiation

    Andrew C Scott;Andrew C Scott;Friederike Dündar;Paul Zumbo;Smita S Chandran

  • Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function

    Madhusudhanan Sukumar;Jie Liu;Yun Ji;Murugan Subramanian

  • CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4 T helper cells and hindered by naturally occurring T regulatory cells.

    Paul A. Antony;Ciriaco A. Piccirillo;Akgül Akpinarli;Steven E. Finkelstein

  • Clinical implications of T cell exhaustion for cancer immunotherapy

    Unknown

  • IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells

    Christopher A. Klebanoff;Steven E. Finkelstein;Deborah R. Surman;Michael K. Lichtman;Michael K. Lichtman

  • Ionic immune suppression within the tumour microenvironment limits T cell effector function

    Robert Eil;Suman K. Vodnala;David Clever;Christopher A. Klebanoff;Christopher A. Klebanoff

  • Paths to stemness: building the ultimate antitumour T cell

    Luca Gattinoni;Christopher A. Klebanoff;Nicholas P. Restifo

  • CD8+ T‐cell memory in tumor immunology and immunotherapy

    Christopher A. Klebanoff;Luca Gattinoni;Nicholas P. Restifo

  • Lymphoma Remissions Caused by Anti-CD19 Chimeric Antigen Receptor T Cells Are Associated With High Serum Interleukin-15 Levels

    James N. Kochenderfer;Robert P.T. Somerville;Tangying Lu;Victoria Shi

  • Sinks, suppressors and antigen presenters: how lymphodepletion enhances T cell-mediated tumor immunotherapy

    Christopher A. Klebanoff;Hung T. Khong;Paul A. Antony;Douglas C. Palmer

  • IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy.

    Christian S. Hinrichs;Rosanne Spolski;Chrystal M. Paulos;Luca Gattinoni

  • T cell stemness and dysfunction in tumors are triggered by a common mechanism.

    Suman Kumar Vodnala;Robert Eil;Rigel J. Kishton;Madhusudhanan Sukumar

  • Th17 Cells Are Long Lived and Retain a Stem Cell-like Molecular Signature

    Pawel Muranski;Zachary A. Borman;Sid P. Kerkar;Christopher A. Klebanoff

  • BACH2 represses effector programs to stabilize T reg -mediated immune homeostasis

    Rahul Roychoudhuri;Kiyoshi Hirahara;Kiyoshi Hirahara;Kambiz Mousavi;David Clever

  • Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

    Stephanie L. Goff;Mark E. Dudley;Deborah E. Citrin;Robert P. Somerville

  • Prospects for gene-engineered T cell immunotherapy for solid cancers.

    Christopher A Klebanoff;Steven A Rosenberg;Nicholas P Restifo

Frequent Co-Authors

Nicholas P. Restifo
Nicholas P. Restifo National Institutes of Health
Luca Gattinoni
Luca Gattinoni University of Regensburg
Douglas C. Palmer
Douglas C. Palmer National Institutes of Health
Zhiya Yu
Zhiya Yu National Institutes of Health
Steven A. Rosenberg
Steven A. Rosenberg National Institutes of Health
James Chih-Hsin Yang
James Chih-Hsin Yang National Taiwan University
David A. Scheinberg
David A. Scheinberg Memorial Sloan Kettering Cancer Center
Ena Wang
Ena Wang Toro bio
Paul F. Robbins
Paul F. Robbins National Cancer Institute
Richard M. Siegel
Richard M. Siegel National Institutes of Health

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