World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Immunology
USA
2026

D-Index & Metrics

Best Scientists

D-Index
193
Citations
160425
World Ranking
375
National Ranking
249

Immunology

D-Index
196
Citations
170039
World Ranking
13
National Ranking
8

Medicine

D-Index
197
Citations
170176
World Ranking
203
National Ranking
136

Research.com Recognitions

  • 2026 - Research.com Immunology in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Immunology in United States Leader Award
  • 2020 - Member of the National Academy of Sciences
  • 2020 - Distinguished Fellows of the American Association of Immunologists (AAI)
  • 2018 - Albany Medical Center Prize in Medicine and Biomedical Research
  • 2015 - Paul Ehrlich and Ludwig Darmstaedter Prize
  • 2014 - Fellow of the American Academy of Arts and Sciences
  • 2014 - Karl Landsteiner Memorial Award, American Association of Blood Banks (AABB)
  • 2014 - AAI-Steinman Award for Human Immunology Research, American Association of Immunologists
  • 2012 - Distinguished Service Award, Clinical Immunology Society
  • 2012 - Member of the National Academy of Medicine (NAM)
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

Carl H. June is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with a significant focus on oncology, immunology, molecular biology, genetics, and biomedical engineering as subfields of study.

The main topics covered in their work include CAR-T cell therapy research, immune cell function and interaction, virus-based gene therapy research, viral infectious diseases and gene expression in insects, immunotherapy and immune responses, CRISPR and genetic engineering, and nanowire synthesis and applications.

Frequent co-authors collaborating with Carl H. June include:

  • Joseph A. Fraietta
  • Regina M. Young
  • Simon F. Lacey
  • John Scholler
  • Bruce L. Levine

They have published regularly in several venues, including:

  • Blood
  • Regular and Young Investigator Award Abstracts
  • Nature Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cytotherapy

Some of their recent notable papers are:

  • "Cytokine Storm," 2020, New England Journal of Medicine
  • "Cytokine release syndrome in severe COVID-19," 2020, Science
  • "CRISPR-engineered T cells in patients with refractory cancer," 2020, Science
  • "Human chimeric antigen receptor macrophages for cancer immunotherapy," 2020, Nature Biotechnology
  • "Decade-long leukaemia remissions with persistence of CD4+ CAR T cells," 2022, Nature

Throughout their career, Carl H. June has received multiple awards, including:

  • Distinguished Fellows of the American Association of Immunologists (AAI), 2020
  • Member of the National Academy of Sciences, 2020
  • Albany Medical Center Prize in Medicine and Biomedical Research, 2018
  • Paul Ehrlich and Ludwig Darmstaedter Prize, 2015
  • AAI-Steinman Award for Human Immunology Research, American Association of Immunologists, 2014
  • Fellow of the American Academy of Arts and Sciences, 2014
  • Karl Landsteiner Memorial Award, American Association of Blood Banks (AABB), 2014
  • Distinguished Service Award, Clinical Immunology Society, 2012
  • Member of the National Academy of Medicine (NAM), 2012
  • Member of the Association of American Physicians

Best Publications

  • Chimeric antigen receptor T cells for sustained remissions in leukemia.

    Shannon L. Maude;Noelle Frey;Pamela A. Shaw;Richard Aplenc

  • Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

    S. L. Maude;Theodore W Laetsch;J. Buechner;S. Rives

  • Chimeric Antigen Receptor–Modified T Cells in Chronic Lymphoid Leukemia

    David L. Porter;Bruce L. Levine;Michael Kalos;Adam Bagg

  • Chimeric antigen receptor-modified T cells for acute lymphoid leukemia.

    Stephan A. Grupp;Michael Kalos;David Barrett;Richard Aplenc

  • T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia

    Michael Kalos;Bruce L. Levine;David L. Porter;Sharyn Katz

  • CAR T cell immunotherapy for human cancer

    Carl H. June;Roddy S. O’Connor;Omkar U. Kawalekar;Saba Ghassemi

  • Cytokine Storm.

    David C Fajgenbaum;Carl H June

  • Chimeric Antigen Receptor Therapy.

    Carl H. June;Michel Sadelain

  • Delivery technologies for cancer immunotherapy

    Rachel S. Riley;Carl H. June;Robert Langer;Michael J. Mitchell

  • A human memory T cell subset with stem cell-like properties

    Luca Gattinoni;Enrico Lugli;Yun Ji;Zoltan Pos

  • Cytokine release syndrome in severe COVID-19.

    John B. Moore;Carl H. June

  • Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

    Stephen J. Schuster;Jakub Svoboda;Elise A. Chong;Sunita D. Nasta

  • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

    David L. Porter;Wei-Ting Hwang;Noelle V. Frey;Simon F. Lacey

  • The B7 and CD28 receptor families

    Carl H. June;Jeffrey A. Bluestone;Lee M. Nadler;Craig B. Thompson

  • A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

    Donald M. O’Rourke;MacLean P. Nasrallah;Arati Desai;Jan J. Melenhorst

  • Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

    Joseph A. Fraietta;Simon F. Lacey;Elena J. Orlando;Iulian Pruteanu-Malinici

  • Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV.

    Pablo Tebas;David Stein;Winson W. Tang;Ian Frank

  • CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

    Lawrence H. Boise;Andy J. Minn;Patricia J. Noel;Carl H. June

  • The CD28 signaling pathway regulates glucose metabolism.

    Kenneth A Frauwirth;James L Riley;Marian H Harris;Richard V Parry

  • Regulatory CD4+CD25+ T Cells in Tumors from Patients with Early-Stage Non-Small Cell Lung Cancer and Late-Stage Ovarian Cancer

    Edward Y. Woo;Christina S. Chu;Theresa J. Goletz;Katia Schlienger

  • Cytokine Release Syndrome in Severe COVID 19: Lessons From Arthritis and Cell Therapy in Cancer Patients Point to Therapy for Severe Disease

    John B. Moore;Carl H. June

Frequent Co-Authors

Bruce L. Levine
Bruce L. Levine University of Pennsylvania
David L. Porter
David L. Porter University of Pennsylvania
Stephan A. Grupp
Stephan A. Grupp Children's Hospital of Philadelphia
Simon F. Lacey
Simon F. Lacey University of Pennsylvania
Michael Kalos
Michael Kalos Next Pillar Consulting
James L. Riley
James L. Riley University of Pennsylvania
J. Joseph Melenhorst
J. Joseph Melenhorst University of Pennsylvania
Michael C. Milone
Michael C. Milone University of Pennsylvania
Edward A. Stadtmauer
Edward A. Stadtmauer University of Pennsylvania
David M. Barrett
David M. Barrett Children's Hospital of Philadelphia

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