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Immunology

D-Index
83
Citations
41665
World Ranking
1413
National Ranking
720

Overview

Simon F. Lacey is affiliated with the University of Pennsylvania in the United States. Their research primarily spans the field of Medicine, with a focus on Oncology, Immunology, Molecular Biology, Genetics, and Biomedical Engineering. The research output reflects a strong emphasis on cellular and molecular aspects of cancer and immune system mechanisms.

The main topics covered in their work include:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Nanowire Synthesis and Applications
  • CRISPR and Genetic Engineering
  • Viral Infectious Diseases and Gene Expression in Insects
  • Cancer Immunotherapy and Biomarkers

Among the frequent publication venues where Simon F. Lacey has contributed are:

  • Blood
  • Journal of Clinical Oncology
  • Molecular Therapy
  • Nature Medicine
  • Blood Advances

Frequent collaborators in their research include the following scientists:

  • Carl H. June
  • J. Joseph Melenhorst
  • Bruce L. Levine
  • Joseph A. Fraietta
  • Megan M. Davis

Representative recent publications by Simon F. Lacey demonstrate an ongoing engagement with cutting-edge immunotherapy and cancer research:

  • "Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications," 2020, Science
  • "CRISPR-engineered T cells in patients with refractory cancer," 2020, Science
  • "Decade-long leukaemia remissions with persistence of CD4+ CAR T cells," 2022, Nature
  • "PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial," 2022, Nature Medicine
  • "An NK-like CAR T cell transition in CAR T cell dysfunction," 2021, Cell

Best Publications

  • Chimeric antigen receptor T cells for sustained remissions in leukemia.

    Shannon L. Maude;Noelle Frey;Pamela A. Shaw;Richard Aplenc

  • Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

    Stephen J. Schuster;Jakub Svoboda;Elise A. Chong;Sunita D. Nasta

  • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

    David L. Porter;Wei-Ting Hwang;Noelle V. Frey;Simon F. Lacey

  • A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

    Donald M. O’Rourke;MacLean P. Nasrallah;Arati Desai;Jan J. Melenhorst

  • Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

    Joseph A. Fraietta;Simon F. Lacey;Elena J. Orlando;Iulian Pruteanu-Malinici

  • Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications

    Divij Mathew;Josephine R. Giles;Amy E. Baxter;Derek A. Oldridge

  • CRISPR-engineered T cells in patients with refractory cancer

    Edward A. Stadtmauer;Joseph A. Fraietta;Megan M. Davis;Adam D. Cohen

  • Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

    Elena Sotillo;David M. Barrett;Kathryn L. Black;Asen Bagashev

  • Decade-long leukaemia remissions with persistence of CD4+ CAR T cells

    Unknown

  • Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia

    David T. Teachey;David T. Teachey;Simon F. Lacey;Pamela A. Shaw;J. Joseph Melenhorst

  • NY-ESO-1–specific TCR–engineered T cells mediate sustained antigen-specific antitumor effects in myeloma

    Aaron P Rapoport;Edward A Stadtmauer;Gwendolyn K Binder-Scholl;Olga Goloubeva

  • Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

    Joseph A. Fraietta;Christopher L. Nobles;Morgan A. Sammons;Morgan A. Sammons;Stefan Lundh

  • B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

    Adam D. Cohen;Alfred L. Garfall;Edward A. Stadtmauer;J. Joseph Melenhorst

  • Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma

    Alfred L. Garfall;Marcela V. Maus;Wei-Ting Hwang;Simon F. Lacey

  • Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

    Marco Ruella;Jun Xu;David M. Barrett;Joseph A. Fraietta

  • PSMA-targeting TGFβ-insensitive armored CAR T cells in metastatic castration-resistant prostate cancer: a phase 1 trial

    Unknown

  • Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

    Christopher C. Kloss;Jihyun Lee;Aaron Zhang;Fang Chen

  • Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.

    Sonia Guedan;Avery D. Posey;Carolyn Shaw;Anna Wing

  • Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

    Marco Ruella;David M. Barrett;Saad S. Kenderian;Olga Shestova

  • PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR.

    Elise A. Chong;J. Joseph Melenhorst;Simon F. Lacey;David E. Ambrose

  • RNA-Based Gene Therapy for HIV with Lentiviral Vector–Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

    David L. DiGiusto;Amrita Krishnan;Lijing Li;Haitang Li

  • Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

    Joseph A. Fraietta;Kyle A. Beckwith;Prachi R. Patel;Marco Ruella

Frequent Co-Authors

Carl H. June
Carl H. June University of Pennsylvania
J. Joseph Melenhorst
J. Joseph Melenhorst University of Pennsylvania
Bruce L. Levine
Bruce L. Levine University of Pennsylvania
David L. Porter
David L. Porter University of Pennsylvania
Stephan A. Grupp
Stephan A. Grupp Children's Hospital of Philadelphia
David M. Barrett
David M. Barrett Children's Hospital of Philadelphia
Don J. Diamond
Don J. Diamond City Of Hope National Medical Center
David T. Teachey
David T. Teachey Children's Hospital of Philadelphia
Michael C. Milone
Michael C. Milone University of Pennsylvania
John A. Zaia
John A. Zaia City Of Hope National Medical Center

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