World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
68
Citations
32583
World Ranking
2540
National Ranking
1216

Overview

J. Joseph Melenhorst is affiliated with the University of Pennsylvania in the United States. Their research focuses predominantly on Medicine, with significant contributions to Biochemistry, Genetics, and Molecular Biology. Subfields of particular emphasis include Oncology, Molecular Biology, Genetics, Immunology, and Biomedical Engineering.

The scientist's recent publications demonstrate sustained work in the area of CAR-T cell therapy and related immunological studies. Notable papers include:

  • Decade-long leukaemia remissions with persistence of CD4+ CAR T cells, 2022, Nature
  • CRISPR-engineered T cells in patients with refractory cancer, 2020, Science
  • Long-Term Outcomes From a Randomized Dose Optimization Study of Chimeric Antigen Receptor Modified T Cells in Relapsed Chronic Lymphocytic Leukemia, 2020, Journal of Clinical Oncology
  • Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL, 2022, Science Advances
  • The model of cytokine release syndrome in CAR T-cell treatment for B-cell non-Hodgkin lymphoma, 2020, Signal Transduction and Targeted Therapy

The prominent research topics covered include CAR-T cell therapy research, Viral Infectious Diseases and Gene Expression in Insects, Immune Cell Function and Interaction, CRISPR and Genetic Engineering, Chronic Lymphocytic Leukemia Research, Virus-based gene therapy research, and Nanowire Synthesis and Applications.

J. Joseph Melenhorst has collaborated frequently with several researchers in the field. Frequent co-authors include Bruce L. Levine, Carl H. June, Simon F. Lacey, Joseph A. Fraietta, and Jaap Jan Boelens.

The scientist's research has appeared primarily in journals such as Cytotherapy, Blood, Cancer Research, Journal of Clinical Oncology, and bioRxiv (Cold Spring Harbor Laboratory). These venues reflect the focus on clinical, translational, and molecular research in cancer immunotherapy and related biomedical domains.

Best Publications

  • Chimeric antigen receptor T cells for sustained remissions in leukemia.

    Shannon L. Maude;Noelle Frey;Pamela A. Shaw;Richard Aplenc

  • Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

    Stephen J. Schuster;Jakub Svoboda;Elise A. Chong;Sunita D. Nasta

  • Chimeric antigen receptor T cells persist and induce sustained remissions in relapsed refractory chronic lymphocytic leukemia

    David L. Porter;Wei-Ting Hwang;Noelle V. Frey;Simon F. Lacey

  • A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma.

    Donald M. O’Rourke;MacLean P. Nasrallah;Arati Desai;Jan J. Melenhorst

  • Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

    Joseph A. Fraietta;Simon F. Lacey;Elena J. Orlando;Iulian Pruteanu-Malinici

  • Convergence of Acquired Mutations and Alternative Splicing of CD19 Enables Resistance to CART-19 Immunotherapy

    Elena Sotillo;David M. Barrett;Kathryn L. Black;Asen Bagashev

  • Identification of Predictive Biomarkers for Cytokine Release Syndrome after Chimeric Antigen Receptor T cell Therapy for Acute Lymphoblastic Leukemia

    David T. Teachey;David T. Teachey;Simon F. Lacey;Pamela A. Shaw;J. Joseph Melenhorst

  • Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

    Joseph A. Fraietta;Christopher L. Nobles;Morgan A. Sammons;Morgan A. Sammons;Stefan Lundh

  • B cell maturation antigen–specific CAR T cells are clinically active in multiple myeloma

    Adam D. Cohen;Alfred L. Garfall;Edward A. Stadtmauer;J. Joseph Melenhorst

  • Chimeric Antigen Receptor T Cells against CD19 for Multiple Myeloma

    Alfred L. Garfall;Marcela V. Maus;Wei-Ting Hwang;Simon F. Lacey

  • Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell

    Marco Ruella;Jun Xu;David M. Barrett;Joseph A. Fraietta

  • Dominant-Negative TGF-β Receptor Enhances PSMA-Targeted Human CAR T Cell Proliferation And Augments Prostate Cancer Eradication

    Christopher C. Kloss;Jihyun Lee;Aaron Zhang;Fang Chen

  • Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.

    Sonia Guedan;Avery D. Posey;Carolyn Shaw;Anna Wing

  • Dual CD19 and CD123 targeting prevents antigen-loss relapses after CD19-directed immunotherapies

    Marco Ruella;David M. Barrett;Saad S. Kenderian;Olga Shestova

  • PD-1 blockade modulates chimeric antigen receptor (CAR)-modified T cells: refueling the CAR.

    Elise A. Chong;J. Joseph Melenhorst;Simon F. Lacey;David E. Ambrose

  • Activity of Mesothelin-Specific Chimeric Antigen Receptor T Cells Against Pancreatic Carcinoma Metastases in a Phase 1 Trial

    Gregory L. Beatty;Mark H. O’Hara;Simon F. Lacey;Drew A. Torigian

  • Ibrutinib enhances chimeric antigen receptor T-cell engraftment and efficacy in leukemia

    Joseph A. Fraietta;Kyle A. Beckwith;Prachi R. Patel;Marco Ruella

  • Cytokine Release Syndrome After Chimeric Antigen Receptor T Cell Therapy for Acute Lymphoblastic Leukemia

    Julie C Fitzgerald;Scott L Weiss;Shannon L Maude;David M Barrett

  • Safety and Efficacy of Intratumoral Injections of Chimeric Antigen Receptor (CAR) T Cells in Metastatic Breast Cancer.

    Julia Tchou;Yangbing Zhao;Bruce L Levine;Paul J Zhang

  • Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.

    Andrew R. Haas;Janos L. Tanyi;Mark H. O’Hara;Whitney L. Gladney

  • Functional leukemia-associated antigen-specific memory CD8+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation.

    Katayoun Rezvani;Matthias Grube;Matthias Grube;Jason M. Brenchley;Jason M. Brenchley;Giuseppe Sconocchia;Giuseppe Sconocchia

Frequent Co-Authors

Simon F. Lacey
Simon F. Lacey University of Pennsylvania
Carl H. June
Carl H. June University of Pennsylvania
Bruce L. Levine
Bruce L. Levine University of Pennsylvania
A. John Barrett
A. John Barrett National Institutes of Health
David L. Porter
David L. Porter University of Pennsylvania
Stephan A. Grupp
Stephan A. Grupp Children's Hospital of Philadelphia
David Price
David Price University of Aberdeen
David M. Barrett
David M. Barrett Children's Hospital of Philadelphia
David T. Teachey
David T. Teachey Children's Hospital of Philadelphia
Daniel C. Douek
Daniel C. Douek National Institute of Allergy and Infectious Diseases

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