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D-Index & Metrics

Biology and Biochemistry

D-Index
83
Citations
24282
World Ranking
3508
National Ranking
1761

Overview

Raymond A. Frizzell is affiliated with the University of Pittsburgh in the United States and focuses primarily on research in the field of Medicine, with significant contributions to Pulmonary and Respiratory Medicine. Their work spans multiple subfields including Molecular Biology, Oncology, Immunology, and Genetics.

Their research topics cover a wide range of areas, notably:

  • Cystic Fibrosis Research Advances
  • Neonatal Respiratory Health Research
  • Drug Transport and Resistance Mechanisms
  • Advanced biosensing and bioanalysis techniques
  • Immunodeficiency and Autoimmune Disorders
  • RNA Interference and Gene Delivery
  • Antimicrobial Peptides and Activities

Frizzell's recent publications illustrate a focus on cystic fibrosis and related respiratory diseases. Selected notable papers include:

  • Co-Translational Folding of the First Transmembrane Domain of ABC-Transporter CFTR is Supported by Assembly with the First Cytosolic Domain (2021, Journal of Molecular Biology)
  • Phenotypes of CF rabbits generated by CRISPR/Cas9-mediated disruption of the CFTR gene (2020, JCI Insight)
  • Separating the contributions of SLC26A9 and CFTR to anion secretion in primary human bronchial epithelia (2021, American Journal of Physiology-Lung Cellular and Molecular Physiology)
  • Improved correction of F508del-CFTR biogenesis with a folding facilitator and an inhibitor of protein ubiquitination (2021, Bioorganic & Medicinal Chemistry Letters)
  • Global assessment of the integrated stress response in CF patient-derived airway and intestinal tissues (2020, Journal of Cystic Fibrosis)

Their frequent coauthors demonstrate collaboration primarily with researchers active in cystic fibrosis and respiratory medicine, including:

  • Mads Larsen
  • Kathryn W. Peters
  • Martina Gentzsch
  • Eric J. Sorscher
  • Bertrand Kleizen

Frizzell publishes regularly in established venues with several articles appearing in UNC Libraries, Journal of Molecular Biology, JCI Insight, Bioorganic & Medicinal Chemistry Letters, and the American Journal of Physiology-Lung Cellular and Molecular Physiology.

Best Publications

  • Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

    Fredrick Van Goor;Sabine Hadida;Peter D. J. Grootenhuis;Bill Burton

  • Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

    Fredrick Van Goor;Sabine Hadida;Peter D. J. Grootenhuis;Bill Burton

  • Correction of the cystic fibrosis defect in vitro by retrovirus-mediated gene transfer.

    Mitchell L. Drumm;Heidi A. Pope;William H. Cliff;Johanna M. Rommens

  • Quantitative Analysis of the Packaging Capacity of Recombinant Adeno-Associated Virus

    Jian-Yun Dong;Pei-Dong Fan;Raymond A. Frizzell

  • Sodium-coupled chloride transport by epithelial tissues

    R. A. Frizzell;M. Field;S. G. Schultz

  • Role of CFTR in airway disease

    Joseph M. Pilewski;Raymond A. Frizzell

  • Aminoglycoside antibiotics restore CFTR function by overcoming premature stop mutations

    Marybeth Howard;Raymond A. Frizzell;Raymond A. Frizzell;David M. Bedwell

  • Ionic Conductances of Extracellular Shunt Pathway in Rabbit Ileum : Influence of shunt on transmural sodium transport and electrical potential differences

    Raymond A. Frizzell;Stanley G. Schultz

  • From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

    Gudio Veit;Radu G. Avramescu;Annette N. Chiang;Scott A. Houck

  • Separate Cl- conductances activated by cAMP and Ca2+ in Cl(-)-secreting epithelial cells.

    William H. Cliff;Raymond A. Frizzell

  • Ion transport by rabbit colon. I. Active and passive components.

    Raymond A. Frizzell;Marilyn J. Koch;Stanley G. Schultz

  • Crypts are the site of intestinal fluid and electrolyte secretion

    Michael J. Welsh;Philip L. Smith;Michael Fromm;Raymond A. Frizzell

  • Bicarbonate and chloride secretion in Calu-3 human airway epithelial cells.

    Daniel C. Devor;Ashvani K. Singh;Linda C. Lambert;Arthur DeLuca

  • Modulation of Cl- secretion by benzimidazolones. I. Direct activation of a Ca(2+)-dependent K+ channel

    D. C. Devor;A. K. Singh;R. A. Frizzell;R. J. Bridges

  • Na+-K+-Cl- co-transport in the intestine of a marine teleost.

    Mark W. Musch;Stephanie A. Orellana;Leigh S. Kimberg;Michael Field

  • Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

    Darren M Hutt;David Herman;Ana P C Rodrigues;Sabrina Noel

  • The role of regulated CFTR trafficking in epithelial secretion

    Carol A. Bertrand;Raymond A. Frizzell

  • E3KARP mediates the association of ezrin and protein kinase A with the cystic fibrosis transmembrane conductance regulator in airway cells.

    Fei Sun;Martin J. Hug;Christopher M. Lewarchik;C.-H. Chris Yun

  • Physiology of Epithelial Chloride and Fluid Secretion

    Raymond A. Frizzell;John W. Hanrahan

  • Bicarbonate and Chloride Secretion in Calu-3 Human Airway

    Daniel C. Devor;Ashvani K. Singh;Linda C. Lambert;Arthur DeLuca

Frequent Co-Authors

Joseph M. Pilewski
Joseph M. Pilewski University of Pittsburgh
Simon C. Watkins
Simon C. Watkins University of Pittsburgh
Gergely L. Lukacs
Gergely L. Lukacs McGill University
Eric J. Sorscher
Eric J. Sorscher Emory University
Paul D. Robbins
Paul D. Robbins University of Minnesota
Harvey B. Pollard
Harvey B. Pollard Uniformed Services University of the Health Sciences
Jeffrey L. Brodsky
Jeffrey L. Brodsky University of Pittsburgh
William E. Balch
William E. Balch Scripps Health
William R. Skach
William R. Skach Cystic Fibrosis Foundation
Ineke Braakman
Ineke Braakman Utrecht University

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