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Biology and Biochemistry

D-Index
53
Citations
8975
World Ranking
16282
National Ranking
6742

Overview

William R. Skach is affiliated with the Cystic Fibrosis Foundation in the United States. Their research focuses primarily on cystic fibrosis and related molecular mechanisms within pulmonary and respiratory medicine, molecular biology, and genetics. Skach's work spans fields of biochemistry, genetics, molecular biology, and medicine.

The main topics addressed in Skach's body of research include:

  • Cystic Fibrosis Research Advances
  • Endoplasmic Reticulum Stress and Disease
  • RNA and protein synthesis mechanisms
  • Neonatal Respiratory Health Research
  • Congenital Ear and Nasal Anomalies
  • Legume Nitrogen Fixing Symbiosis
  • Advanced biosensing and bioanalysis techniques

Skach has contributed to multiple research articles published in notable scientific venues. Frequent publication venues include:

  • Journal of Cystic Fibrosis
  • Cell Reports
  • Scientific Reports
  • UNC Libraries
  • Nature Communications

Some of Skach's recent papers include:

  • In vitro modulator responsiveness of 655 CFTR variants found in people with cystic fibrosis, 2024, Journal of Cystic Fibrosis
  • CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates, 2020, Nature Communications
  • Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR, 2020, Journal of Cystic Fibrosis
  • A role for the ribosome-associated complex in activation of the IRE1 branch of UPR, 2021, Cell Reports
  • In Vitro Modulator Responsiveness of 655 CFTR Variants Found in People With CF, 2023, bioRxiv (Cold Spring Harbor Laboratory)

Skach frequently collaborates with several coauthors, including:

  • Jae Seok Yoon
  • Philip Thomas
  • Hideki Shishido
  • Garry R. Cutting
  • Martin Mense

The scientist's research covers an integration of cellular and molecular processes related to cystic fibrosis, such as folding and function of CFTR protein variants, cotranslational protein folding, and cellular stress responses associated with endoplasmic reticulum function.

Best Publications

  • Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.

    Hajime Hasegawa;Tonghui Ma;William Skach;Michael A. Matthay

  • From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

    Gudio Veit;Radu G. Avramescu;Annette N. Chiang;Scott A. Houck

  • Water transport across mammalian cell membranes.

    A. S. Verkman;A. N. van Hoek;T. Ma;A. Frigeri

  • Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

    Jeffrey L Brodsky;William R Skach

  • Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

    Darren M Hutt;David Herman;Ana P C Rodrigues;Sabrina Noel

  • “CFTR Modulator Theratyping: Current Status, Gaps and Future Directions”

    John Paul Clancy;Calvin U. Cotton;Scott H. Donaldson;George M. Solomon

  • Translational tuning optimizes nascent protein folding in cells

    Soo Jung Kim;Jae Seok Yoon;Hideki Shishido;Zhongying Yang

  • Sequential triage of transmembrane segments by Sec61α during biogenesis of a native multispanning membrane protein

    Heather Sadlish;David Pitonzo;Arthur E Johnson;Arthur E Johnson;William R Skach

  • Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System

    Judit Wahlman;George N. DeMartino;William R. Skach;Neil J. Bulleid

  • Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

    W R Skach;M C Calayag;V R Lingappa

  • Identification of a Human cDNA Clone for Lysosomal Type Ca2+-independent Phospholipase A2 and Properties of the Expressed Protein *

    Tae Suk Kim;Chennarayapatna S. Sundaresh;Sheldon I. Feinstein;Chandra Dodia

  • A multifunctional aqueous channel formed by CFTR.

    H Hasegawa;W Skach;O Baker;MC Calayag

  • CO- AND POSTTRANSLATIONAL TRANSLOCATION MECHANISMS DIRECT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR N TERMINUS TRANSMEMBRANE ASSEMBLY

    Yun Lu;Ximing Xiong;Andrew Helm;Kabuiya Kimani

  • Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the ER membrane.

    Ximing Xiong;Elaine Chong;William R. Skach

  • Cellular mechanisms of membrane protein folding

    William R. Skach

  • Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.

    Toru Shibatani;Larry L. David;Ashley L. McCormack;Klaus Frueh

  • Cystic Fibrosis Transmembrane Conductance Regulator–associated ATP Release Is Controlled by a Chloride Sensor

    Qinshi Jiang;Daniel Mak;Sreenivas Devidas;Erik M. Schwiebert

  • Reorientation of Aquaporin-1 Topology during Maturation in the Endoplasmic Reticulum

    Yun Lu;Isaiah R. Turnbull;Alvina Bragin;Kristin Carveth

  • Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers

    Lan Bo Shi;William R. Skach;A. S. Verkman

  • Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28.

    Rubin Zhang;W. Skach;H. Hasegawa;A. N. Van Hoek

Frequent Co-Authors

Alan S. Verkman
Alan S. Verkman University of California, San Francisco
Arthur E. Johnson
Arthur E. Johnson Texas A&M University
Tonghui Ma
Tonghui Ma Dalian Medical University
Antonio Frigeri
Antonio Frigeri University of Bari Aldo Moro
Eric J. Sorscher
Eric J. Sorscher Emory University
William B. Guggino
William B. Guggino Johns Hopkins University
William E. Balch
William E. Balch Scripps Health
Raymond A. Frizzell
Raymond A. Frizzell University of Pittsburgh
Philip J. Thomas
Philip J. Thomas The University of Texas Southwestern Medical Center
Carol Deutsch
Carol Deutsch University of Pennsylvania

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