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William R. Skach

D-Index & Metrics

Biology and Biochemistry

D-Index
53
Citations
8975
World Ranking
16282
National Ranking
6742

William R. Skach publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where William R. Skach sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 106 publications — 7th percentile

7% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

William R. Skach D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where William R. Skach sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 53 D-Index — 19th percentile

19% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

William R. Skach is affiliated with the Cystic Fibrosis Foundation in the United States. Their research focuses primarily on cystic fibrosis and related molecular mechanisms within pulmonary and respiratory medicine, molecular biology, and genetics. Skach's work spans fields of biochemistry, genetics, molecular biology, and medicine.

The main topics addressed in Skach's body of research include:

  • Cystic Fibrosis Research Advances
  • Endoplasmic Reticulum Stress and Disease
  • RNA and protein synthesis mechanisms
  • Neonatal Respiratory Health Research
  • Congenital Ear and Nasal Anomalies
  • Legume Nitrogen Fixing Symbiosis
  • Advanced biosensing and bioanalysis techniques

Skach has contributed to multiple research articles published in notable scientific venues. Frequent publication venues include:

  • Journal of Cystic Fibrosis
  • Cell Reports
  • Scientific Reports
  • UNC Libraries
  • Nature Communications

Some of Skach's recent papers include:

  • In vitro modulator responsiveness of 655 CFTR variants found in people with cystic fibrosis, 2024, Journal of Cystic Fibrosis
  • CFTR trafficking mutations disrupt cotranslational protein folding by targeting biosynthetic intermediates, 2020, Nature Communications
  • Towards next generation therapies for cystic fibrosis: Folding, function and pharmacology of CFTR, 2020, Journal of Cystic Fibrosis
  • A role for the ribosome-associated complex in activation of the IRE1 branch of UPR, 2021, Cell Reports
  • In Vitro Modulator Responsiveness of 655 CFTR Variants Found in People With CF, 2023, bioRxiv (Cold Spring Harbor Laboratory)

Skach frequently collaborates with several coauthors, including:

  • Jae Seok Yoon
  • Philip Thomas
  • Hideki Shishido
  • Garry R. Cutting
  • Martin Mense

The scientist's research covers an integration of cellular and molecular processes related to cystic fibrosis, such as folding and function of CFTR protein variants, cotranslational protein folding, and cellular stress responses associated with endoplasmic reticulum function.

Best Publications

  • Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues.

    Hajime Hasegawa;Tonghui Ma;William Skach;Michael A. Matthay

  • From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations.

    Gudio Veit;Radu G. Avramescu;Annette N. Chiang;Scott A. Houck

  • Water transport across mammalian cell membranes.

    A. S. Verkman;A. N. van Hoek;T. Ma;A. Frigeri

  • Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

    Jeffrey L Brodsky;William R Skach

  • Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis

    Darren M Hutt;David Herman;Ana P C Rodrigues;Sabrina Noel

  • “CFTR Modulator Theratyping: Current Status, Gaps and Future Directions”

    John Paul Clancy;Calvin U. Cotton;Scott H. Donaldson;George M. Solomon

  • Translational tuning optimizes nascent protein folding in cells

    Soo Jung Kim;Jae Seok Yoon;Hideki Shishido;Zhongying Yang

  • Sequential triage of transmembrane segments by Sec61α during biogenesis of a native multispanning membrane protein

    Heather Sadlish;David Pitonzo;Arthur E Johnson;Arthur E Johnson;William R Skach

  • Real-Time Fluorescence Detection of ERAD Substrate Retrotranslocation in a Mammalian In Vitro System

    Judit Wahlman;George N. DeMartino;William R. Skach;Neil J. Bulleid

  • Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

    W R Skach;M C Calayag;V R Lingappa

  • Identification of a Human cDNA Clone for Lysosomal Type Ca2+-independent Phospholipase A2 and Properties of the Expressed Protein *

    Tae Suk Kim;Chennarayapatna S. Sundaresh;Sheldon I. Feinstein;Chandra Dodia

  • A multifunctional aqueous channel formed by CFTR.

    H Hasegawa;W Skach;O Baker;MC Calayag

  • CO- AND POSTTRANSLATIONAL TRANSLOCATION MECHANISMS DIRECT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR N TERMINUS TRANSMEMBRANE ASSEMBLY

    Yun Lu;Ximing Xiong;Andrew Helm;Kabuiya Kimani

  • Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the ER membrane.

    Ximing Xiong;Elaine Chong;William R. Skach

  • Cellular mechanisms of membrane protein folding

    William R. Skach

  • Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits.

    Toru Shibatani;Larry L. David;Ashley L. McCormack;Klaus Frueh

  • Cystic Fibrosis Transmembrane Conductance Regulator–associated ATP Release Is Controlled by a Chloride Sensor

    Qinshi Jiang;Daniel Mak;Sreenivas Devidas;Erik M. Schwiebert

  • Reorientation of Aquaporin-1 Topology during Maturation in the Endoplasmic Reticulum

    Yun Lu;Isaiah R. Turnbull;Alvina Bragin;Kristin Carveth

  • Functional independence of monomeric CHIP28 water channels revealed by expression of wild-type mutant heterodimers

    Lan Bo Shi;William R. Skach;A. S. Verkman

  • Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28.

    Rubin Zhang;W. Skach;H. Hasegawa;A. N. Van Hoek

Frequent Co-Authors

Alan S. Verkman
Alan S. Verkman University of California, San Francisco
Arthur E. Johnson
Arthur E. Johnson Texas A&M University
Tonghui Ma
Tonghui Ma Dalian Medical University
Antonio Frigeri
Antonio Frigeri University of Bari Aldo Moro
Eric J. Sorscher
Eric J. Sorscher Emory University
William B. Guggino
William B. Guggino Johns Hopkins University
William E. Balch
William E. Balch Scripps Health
Raymond A. Frizzell
Raymond A. Frizzell University of Pittsburgh
Philip J. Thomas
Philip J. Thomas The University of Texas Southwestern Medical Center
Carol Deutsch
Carol Deutsch University of Pennsylvania

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Exploring these diverse online degree options can help you tailor your education to specific career goals in the dynamic fields of biology, healthcare, and science.

Best Scientists Citing William R. Skach

Alan S. Verkman

Alan S. Verkman

University of California, San Francisco

Publications: 107

Gunnar von Heijne

Gunnar von Heijne

Stockholm University

Publications: 60

Søren Nielsen

Søren Nielsen

Aalborg University

Publications: 53

Peter Agre

Peter Agre

Johns Hopkins University

Publications: 49

Jeffrey L. Brodsky

Jeffrey L. Brodsky

University of Pittsburgh

Publications: 39

William E. Balch

William E. Balch

Scripps Health

Publications: 30

Antonio Frigeri

Antonio Frigeri

University of Bari Aldo Moro

Publications: 27

Gergely L. Lukacs

Gergely L. Lukacs

McGill University

Publications: 27

Tonghui Ma

Tonghui Ma

Dalian Medical University

Publications: 26

Aron B. Fisher

Aron B. Fisher

University of Pennsylvania

Publications: 24

Arthur E. Johnson

Arthur E. Johnson

Texas A&M University

Publications: 23

Richard Zimmermann

Richard Zimmermann

Saarland University

Publications: 23

Margarida D. Amaral

Margarida D. Amaral

University of Lisbon

Publications: 23

Baoxue Yang

Baoxue Yang

Peking University

Publications: 23

Maria Svelto

Maria Svelto

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Publications: 23

Ramanujan S. Hegde

Ramanujan S. Hegde

MRC Laboratory of Molecular Biology

Publications: 19

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