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Neuroscience

D-Index
58
Citations
15327
World Ranking
4121
National Ranking
114

Overview

Paul A. Adlard is affiliated with the Florey Institute of Neuroscience and Mental Health in Australia. Their research primarily focuses on the broad field of medicine, with a significant emphasis on trace elements in health, neurological diseases, and neurodegenerative conditions.

The main topics covered in their work include:

  • Trace Elements in Health
  • Alzheimer's Disease Research and Treatments
  • Heavy Metal Exposure and Toxicity
  • Traumatic Brain Injury Research
  • Traumatic Brain Injury and Neurovascular Disturbances
  • Parkinson's Disease Mechanisms and Treatments
  • Neurological Diseases and Metabolism

Adlard's research spans subfields such as nutrition and dietetics, neurology, physiology, molecular biology, and health, toxicology, and mutagenesis. These areas illustrate their multidisciplinary approach towards understanding disease mechanisms and potential therapeutic avenues.

Their recent publications include:

  • "Fibrillar α-synuclein toxicity depends on functional lysosomes," 2020, Journal of Biological Chemistry
  • "The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy," 2020, Journal of Alzheimer s Disease
  • "RETRACTED: The Iron Chelator Deferiprone Improves the Phenotype in a Mouse Model of Tauopathy1," 2020, Journal of Alzheimer s Disease
  • "The Long Isoform of Intersectin-1 Has a Role in Learning and Memory," 2020, Frontiers in Behavioral Neuroscience
  • "Alzheimer risk factors age and female sex induce cortical Aβ aggregation by raising extracellular zinc," 2020, Molecular Psychiatry

Frequent co-authors collaborating with Paul A. Adlard are:

  • Ashley I. Bush
  • David I. Finkelstein
  • Shalini S. Rao
  • Larissa Lago
  • Sydney M. A. Juan

The majority of Adlard's publications appear in journals such as:

  • Journal of Alzheimer s Disease
  • Neurotherapeutics
  • Journal of Biological Chemistry
  • Metallomics
  • Acta Neuropathologica Communications

The research contributions by Paul A. Adlard address significant topics in neurodegeneration, particularly focusing on how trace metals affect Alzheimer's and Parkinson's disease progression, along with exploring heavy metal toxicity and the biochemical pathways involved in brain injury and recovery.

Best Publications

  • Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease

    Paul A. Adlard;Victoria M. Perreau;Viorela Pop;Carl W. Cotman

  • Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

    Paul A. Adlard;Robert A. Cherny;Robert A. Cherny;David I. Finkelstein;David I. Finkelstein;Elisabeth Gautier

  • Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

    Tuo Qz;Tuo Qz;Tuo Qz;Lei P;Lei P;Jackman Ka;Li Xl

  • Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

    Peng Lei;Scott Ayton;David I Finkelstein;Loredana Spoerri

  • Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

    Paul A Adlard;Jacqui M Parncutt;David I Finkelstein;Ashley I Bush

  • Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus.

    Nicole C. Berchtold;J. Patrick Kesslak;Christian J. Pike;Paul A. Adlard

  • Mitochondrial oxidative stress causes hyperphosphorylation of tau.

    Simon Melov;Paul A. Adlard;Karl Morten;Felicity Johnson

  • Metals and Alzheimer's disease.

    Paul A Adlard;Ashley I Bush

  • 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer’s disease

    Michelle T Fodero-Tavoletti;Nobuyuki Okamura;Shozo Furumoto;Rachel S Mulligan

  • Voluntary exercise protects against stress-induced decreases in brain-derived neurotrophic factor protein expression.

    P.A. Adlard;C.W. Cotman

  • The exercise-induced expression of BDNF within the hippocampus varies across life-span

    Paul A. Adlard;Victoria M. Perreau;Carl W. Cotman

  • Ferroptosis and cell death mechanisms in Parkinson's disease.

    Stephanie J. Guiney;Paul A. Adlard;Ashley I. Bush;David I. Finkelstein

  • Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.

    Shashank Masaldan;Sharnel A.S. Clatworthy;Cristina Gamell;Peter M. Meggyesy

  • Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation

    Peter J. Crouch;Lin Wai Hung;Paul A. Adlard;Mikhalina Cortes

  • The cause of neuronal degeneration in Alzheimer's disease.

    James C. Vickers;Tracey C. Dickson;Paul A. Adlard;Helen L. Saunders

  • Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.

    Scott Ayton;Peng Lei;James A. Duce;Bruce X. W. Wong

  • The timecourse of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise

    Paul A. Adlard;Victoria M. Perreau;Christie Engesser-Cesar;Carl W. Cotman

  • Tau protein: Relevance to Parkinson's disease

    Peng Lei;Scott Ayton;Scott Ayton;David I Finkelstein;David I Finkelstein;Paul A Adlard;Paul A Adlard

  • The Alzheimer's therapeutic PBT2 promotes amyloid-β degradation and GSK3 phosphorylation via a metal chaperone activity

    Peter J Crouch;Maria S Savva;Lin W Hung;Lin W Hung;Paul S Donnelly

  • Zinc and Copper Modulate Alzheimer Aβ Levels in Human Cerebrospinal Fluid

    Dorothea Strozyk;Lenore J. Launer;Paul A. Adlard;Robert A. Cherny

  • GSK-3 in Neurodegenerative Diseases

    Peng Lei;Peng Lei;Scott Ayton;Scott Ayton;Ashley I. Bush;Ashley I. Bush;Paul A. Adlard;Paul A. Adlard

  • Elevated labile Cu is associated with oxidative pathology in Alzheimer disease.

    Simon A. James;Irene Volitakis;Paul A. Adlard;James A. Duce

Frequent Co-Authors

Colin L. Masters
Colin L. Masters University of Melbourne
Scott Ayton
Scott Ayton Florey Institute of Neuroscience and Mental Health
James C. Vickers
James C. Vickers University of Tasmania
Tracey C. Dickson
Tracey C. Dickson University of Tasmania
Adrian K. West
Adrian K. West University of Tasmania
Carl W. Cotman
Carl W. Cotman University of California, Irvine
Anthony J. Hannan
Anthony J. Hannan Florey Institute of Neuroscience and Mental Health
Roger S. Chung
Roger S. Chung Macquarie University
Nobuyuki Okamura
Nobuyuki Okamura Tohoku Medical and Pharmaceutical University
Kazuhiko Yanai
Kazuhiko Yanai Tohoku University

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