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2025
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Neuroscience
USA
2026

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Best Scientists

D-Index
247
Citations
220130
World Ranking
53
National Ranking
36

Neuroscience

D-Index
251
Citations
229974
World Ranking
7
National Ranking
5

Research.com Recognitions

  • 2026 - Research.com Neuroscience in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Neuroscience in United States Leader Award
  • 2023 - Research.com Medicine in United States Leader Award
  • 2010 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Mark P. Mattson is affiliated with Johns Hopkins University School of Medicine in the United States. Their research spans multiple disciplines, with primary fields of study including Medicine and Biochemistry, Genetics and Molecular Biology. Within these areas, Mattson's work contributes notably to subfields such as Physiology, Molecular Biology, Neurology, Endocrine and Autonomic Systems, and Immunology.

Their research topics cover a range of scientific inquiries with a particular focus on:

  • Dietary Effects on Health
  • Diet and metabolism studies
  • Alzheimer's disease research and treatments
  • Adipose Tissue and Metabolism
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Mitochondrial Function and Pathology
  • Circadian rhythm and melatonin

Among their recent publications are several influential papers, including:

  • Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing, 2020, Nature Reviews Drug Discovery
  • NAD + supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING, 2021, Proceedings of the National Academy of Sciences
  • Intermittent and periodic fasting, longevity and disease, 2021, Nature Aging
  • Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease, 2020, Neurobiology of Disease
  • Glucose metabolic crosstalk and regulation in brain function and diseases, 2021, Progress in Neurobiology

Frequent collaborators in Mattson's research include Dong-Gyu Jo, Thiruma V. Arumugam, Christopher G. Sobey, Jayantha Gunaratne, and Ross A. McDevitt.

Mark P. Mattson's work has been published repeatedly in several scientific venues, with significant contributions appearing in:

  • Trends in Neurosciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Cell Metabolism
  • International review of neurobiology
  • Cells

In addition to journal publications, Mattson has authored books published by The MIT Press, including The Intermittent Fasting Revolution (2022) and Sculptor and Destroyer (2023).

Recognition of their scientific contributions includes being named a Fellow of the American Association for the Advancement of Science (AAAS) in 2010.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles: Intracellular Aβ and Synaptic Dysfunction

    Salvatore Oddo;Antonella Caccamo;Jason D. Shepherd;M. Paul Murphy

  • Pathways towards and away from Alzheimer's disease

    Mark P. Mattson

  • beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

    Mark P. Mattson;Bin Cheng;Dave Davis;Karin Bryant

  • Apoptosis in neurodegenerative disorders

    Mark P. Mattson

  • Self-Propagating, Molecular-Level Polymorphism in Alzheimer's ß-Amyloid Fibrils

    Aneta T. Petkova;Richard D. Leapman;Zhihong Guo;Wai Ming Yau

  • Fasting: Molecular Mechanisms and Clinical Applications

    Valter D. Longo;Mark P. Mattson;Mark P. Mattson

  • Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

    E F Fang;Y Hou;K Palikaras;B A Adriaanse

  • A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

    K Hensley;J M Carney;M P Mattson;M Aksenova

  • Effects of Intermittent Fasting on Health, Aging, and Disease

    Rafael de Cabo;Mark P Mattson

  • Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

    Mark P. Mattson

  • Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

    Roy G. Cutler;Jeremiah Kelly;Kristin Storie;Ward A. Pedersen

  • Ageing and neuronal vulnerability

    Mark P. Mattson;Tim Magnus

  • Mitochondrial Manganese Superoxide Dismutase Prevents Neural Apoptosis and Reduces Ischemic Brain Injury: Suppression of Peroxynitrite Production, Lipid Peroxidation, and Mitochondrial Dysfunction

    Jeffrey N. Keller;Mark S. Kindy;Fredrick W. Holtsberg;Daret K. St. Clair

  • Impact of intermittent fasting on health and disease processes

    Mark P. Mattson;Valter D. Longo;Michelle Harvie

  • BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

    Mark P. Mattson;Mark P. Mattson;Stuart Maudsley;Bronwen Martin

  • Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

    Annadora J. Bruce;Warren Boling;Mark S. Kindy;Jacques Peschon

  • Mitochondria in Neuroplasticity and Neurological Disorders

    Unknown

  • A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide

    Robert J. Mark;Mark A. Lovell;William R. Markesbery;Koji Uchida

  • Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.

    Mark P. Mattson;Mark P. Mattson;Thiruma V. Arumugam

  • NF-κB in neuronal plasticity and neurodegenerative disorders

    Mark P. Mattson;Simonetta Camandola

  • Folate and homocysteine metabolism in neural plasticity and neurodegenerative disorders.

    Mark P Mattson;Thomas B Shea

Frequent Co-Authors

Thiruma V. Arumugam
Thiruma V. Arumugam La Trobe University
Sic L. Chan
Sic L. Chan University of Central Florida
Mahendra S. Rao
Mahendra S. Rao National Institutes of Health
Vilhelm A. Bohr
Vilhelm A. Bohr University of Copenhagen
Dong-Gyu Jo
Dong-Gyu Jo Sungkyunkwan University
Nigel H. Greig
Nigel H. Greig National Institutes of Health
Jaewon Lee
Jaewon Lee Pusan National University
Norman J. Haughey
Norman J. Haughey Tulane University
Jeffrey N. Keller
Jeffrey N. Keller Pennington Biomedical Research Center
Alexis M. Stranahan
Alexis M. Stranahan Augusta University

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