H-Index & Metrics Best Publications

H-Index & Metrics

Discipline name H-index Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 90 Citations 32,551 215 World Ranking 1095 National Ranking 659

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Amino acid

Biochemistry, Cell biology, Cystic fibrosis transmembrane conductance regulator, Aquaporin and Chloride channel are his primary areas of study. His Biochemistry study frequently draws connections between related disciplines such as Biophysics. His Cell biology research includes elements of Cell, Autocrine signalling and Membrane protein.

His research integrates issues of Apical membrane, Molecular biology and Intracellular in his study of Cystic fibrosis transmembrane conductance regulator. His Aquaporin research is multidisciplinary, incorporating elements of Integral membrane protein, Xenopus, Membrane, Membrane transport and Molecular cloning. William B. Guggino focuses mostly in the field of Chloride channel, narrowing it down to topics relating to Regulator and, in certain cases, Mutant, Agonist and Purinergic receptor.

His most cited work include:

  • Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein (1660 citations)
  • In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium (1066 citations)
  • Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents (692 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Cell biology, Cystic fibrosis transmembrane conductance regulator, Cystic fibrosis, Molecular biology and Internal medicine. His research on Cell biology also deals with topics like

  • Biochemistry which is related to area like Biophysics,
  • Cell culture which intersects with area such as Secretion. His research in Cystic fibrosis transmembrane conductance regulator intersects with topics in Mutant, Cyclic nucleotide-binding domain, Chloride channel, Transmembrane domain and Apical membrane.

As part of the same scientific family, he usually focuses on Cystic fibrosis, concentrating on Genetic enhancement and intersecting with Adeno-associated virus and Transduction. William B. Guggino has included themes like Gene expression, Immunoprecipitation, Transfection, Green fluorescent protein and Wild type in his Molecular biology study. His Internal medicine study combines topics in areas such as Endocrinology and Signal transduction.

He most often published in these fields:

  • Cell biology (35.91%)
  • Cystic fibrosis transmembrane conductance regulator (29.19%)
  • Cystic fibrosis (24.16%)

What were the highlights of his more recent work (between 2009-2020)?

  • Cystic fibrosis transmembrane conductance regulator (29.19%)
  • Cell biology (35.91%)
  • Cystic fibrosis (24.16%)

In recent papers he was focusing on the following fields of study:

William B. Guggino mainly focuses on Cystic fibrosis transmembrane conductance regulator, Cell biology, Cystic fibrosis, Molecular biology and Mutant. His Cystic fibrosis transmembrane conductance regulator research incorporates themes from Protein structure, Heat shock protein, Protein degradation and ATP-binding cassette transporter. His Cell biology research incorporates elements of HEK 293 cells and Syntaxin.

He combines subjects such as Adeno-associated virus, Genetic enhancement, Transduction, Lung and Rhesus macaque with his study of Cystic fibrosis. His studies in Molecular biology integrate themes in fields like Wild type, Cell membrane, Chinese hamster ovary cell and Immunoprecipitation. His studies deal with areas such as Mutation, Chloride channel, Stargardt disease and ABCA4 as well as Mutant.

Between 2009 and 2020, his most popular works were:

  • From CFTR biology toward combinatorial pharmacotherapy: expanded classification of cystic fibrosis mutations. (233 citations)
  • Drosophila TRPA1 channel mediates chemical avoidance in gustatory receptor neurons (133 citations)
  • Drosophila TRPA1 channel is required to avoid the naturally occurring insect repellent citronellal. (127 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Amino acid

William B. Guggino mostly deals with Cystic fibrosis transmembrane conductance regulator, Cell biology, Molecular biology, ΔF508 and Mutant. His research in Cystic fibrosis transmembrane conductance regulator focuses on subjects like ATP-binding cassette transporter, which are connected to Nucleotide. His Cell biology research integrates issues from Drosophila melanogaster, Drosophila Protein, Biochemistry and Immunoprecipitation.

His Molecular biology research is multidisciplinary, relying on both Reprogramming, PDZ domain and Syntaxin. Within one scientific family, William B. Guggino focuses on topics pertaining to Protein structure under ΔF508, and may sometimes address concerns connected to Transmembrane domain and Endoplasmic reticulum. His Cystic fibrosis course of study focuses on Genetic enhancement and Immunology and Vectors in gene therapy.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Appearance of Water Channels in Xenopus Oocytes Expressing Red Cell CHIP28 Protein

Gregory M. Preston;Tiziana Piazza Carroll;William B. Guggino;Peter Agre.
Science (1992)

2411 Citations

In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium

Melissa A. Rosenfeld;Kunihiko Yoshimura;Bruce C. Trapnell;Koichi Yoneyama.
Cell (1992)

1257 Citations

Aquaporin CHIP: the archetypal molecular water channel

P. Agre;G. M. Preston;B. L. Smith;Jin Sup Jung.
American Journal of Physiology-renal Physiology (1993)

992 Citations

Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents

Kazushige Hanaoka;Feng Qian;Alessandra Boletta;Anil K. Bhunia.
Nature (2000)

845 Citations

Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance

Jin Sup Jung;Ratan V. Bhat;Gregory M. Preston;William B. Guggino.
Proceedings of the National Academy of Sciences of the United States of America (1994)

837 Citations

Molecular structure of the water channel through aquaporin CHIP. The hourglass model.

Jin Sup Jung;G. M. Preston;B. L. Smith;W. B. Guggino.
Journal of Biological Chemistry (1994)

790 Citations

CFTR regulates outwardly rectifying chloride channels through an autocrine mechanism involving ATP.

Erik M. Schwiebert;Marie E. Egan;Tae Ho Hwang;Stephanie B. Fulmer.
Cell (1995)

755 Citations

The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel.

G. M. Preston;Jin Sup Jung;W. B. Guggino;P. Agre.
Journal of Biological Chemistry (1993)

673 Citations

Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector.

Terence R. Flotte;Sandra A. Afione;Carol Conrad;Sharon A. McGrath.
Proceedings of the National Academy of Sciences of the United States of America (1993)

672 Citations

Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout

Owen M. Woodward;Anna Köttgen;Josef Coresh;Eric Boerwinkle.
Proceedings of the National Academy of Sciences of the United States of America (2009)

621 Citations

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