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Biology and Biochemistry

D-Index
66
Citations
16060
World Ranking
8646
National Ranking
3879

Overview

Pamela L. Zeitlin is affiliated with National Jewish Health in the United States. Their research primarily focuses on medicine, with a significant emphasis on pulmonary and respiratory medicine. Their work extends into related subfields, including physiology, immunology, plant science, and surgery.

The scientist's main topics of study include cystic fibrosis research advances, neonatal respiratory health research, asthma and respiratory diseases, tracheal and airway disorders, eosinophilic esophagitis, IL-33, ST2, and ILC pathways, and legume nitrogen-fixing symbiosis.

Pamela L. Zeitlin has contributed multiple papers that cover important aspects of respiratory function and diseases. Notable recent publications include:

  • Elexacaftor is a CFTR potentiator and acts synergistically with ivacaftor during acute and chronic treatment (2021, Scientific Reports)
  • IL-13-programmed airway tuft cells produce PGE2, which promotes CFTR-dependent mucociliary function (2022, JCI Insight)
  • A common polymorphism in the Intelectin-1 gene influences mucus plugging in severe asthma (2024, Nature Communications)
  • Effect of apical chloride concentration on the measurement of responses to CFTR modulation in airway epithelia cultured from nasal brushings (2020, Physiological Reports)
  • Receptor-mediated activation of CFTR via prostaglandin signaling pathways in the airway (2022, American Journal of Physiology-Lung Cellular and Molecular Physiology)

The frequent coauthors collaborating with Pamela L. Zeitlin include Preston E. Bratcher, Ciarán A. Shaughnessy, Sangya Yadav, Camille M. Moore, and Michael T. Montgomery. These collaborations have contributed to the scientist's research outputs, particularly in pulmonary and respiratory medicine.

Publication venues where Pamela L. Zeitlin has frequently contributed include:

  • Scientific Reports
  • Journal of Cystic Fibrosis
  • JCI Insight
  • Nature Communications
  • Physiological Reports

Their research topics span advanced studies on cystic fibrosis, respiratory health conditions from neonatal stages to asthma and airway disorders, and molecular pathways influencing respiratory epithelial function. The integration of these topics reflects a comprehensive engagement with medical and physiological aspects of respiratory disease mechanisms and therapies.

Best Publications

  • Stable in vivo expression of the cystic fibrosis transmembrane conductance regulator with an adeno-associated virus vector.

    Terence R. Flotte;Sandra A. Afione;Carol Conrad;Sharon A. McGrath

  • Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.

    Benjamin C. Tang;Michelle Dawson;Michelle Dawson;Samuel K. Lai;Ying Ying Wang

  • Defective regulation of outwardly rectifying Cl− channels by protein kinase A corrected by insertion of CFTR

    Marie Egan;Terence Flotte;Terence Flotte;Sandra Afione;Rikki Solow

  • Immunocytochemical localization of the cystic fibrosis gene product CFTR.

    Isabelle Crawford;Peter C. Maloney;Pamela L. Zeitlin;William B. Guggino

  • A pilot clinical trial of oral sodium 4-phenylbutyrate (Buphenyl) in deltaF508-homozygous cystic fibrosis patients: partial restoration of nasal epithelial CFTR function.

    Ronald C. Rubenstein;Pamela L. Zeitlin

  • In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing delta F508-CFTR.

    Ronald C. Rubenstein;Marie E. Egan;Pamela L. Zeitlin

  • Expression of the cystic fibrosis transmembrane conductance regulator from a novel adeno-associated virus promoter

    Terence R. Flotte;Sandra A. Afione;Rikki Solow;Mitchell L. Drumm

  • A Cystic Fibrosis Bronchial Epithelial Cell Line: Immortalization by Adeno-12-SV40 Infection

    P. L. Zeitlin;L. Lu;J. Rhim;G. Cutting

  • Significant microbiological effect of inhaled tobramycin in young children with cystic fibrosis.

    Ronald L. Gibson;Julia Emerson;Sharon McNamara;Jane L. Burns

  • The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non-adhesive polymer nanoparticles.

    Jung Soo Suk;Samuel K. Lai;Ying Ying Wang;Laura M. Ensign

  • Sodium 4-phenylbutyrate downregulates Hsc70: implications for intracellular trafficking of ΔF508-CFTR

    Ronald C. Rubenstein;Pamela L. Zeitlin

  • Repeated adeno-associated virus serotype 2 aerosol-mediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial.

    Richard B. Moss;David Rodman;L. Terry Spencer;Moira L. Aitken

  • Ataluren for the treatment of nonsense-mutation cystic fibrosis: a randomised, double-blind, placebo-controlled phase 3 trial

    Eitan Kerem;Michael W Konstan;Kris De Boeck;Frank J Accurso

  • Phase I Trial of Intranasal and Endobronchial Administration of a Recombinant Adeno-Associated Virus Serotype 2 (rAAV2)-CFTR Vector in Adult Cystic Fibrosis Patients: A Two-Part Clinical Study

    Terence R. Flotte;Pamela L. Zeitlin;Thomas C. Reynolds;Alison E. Heald

  • Gene Expression from Adeno-associated Virus Vectors in Airway Epithelial Cells

    Terence R. Flotte;Rikki Solow;Roland A. Owens;Sandra Afione

  • Mutation in the gene responsible for cystic fibrosis and predisposition to chronic rhinosinusitis in the general population

    Xin Jing Wang;Birgitta Moylan;Donald A. Leopold;Jean Kim

  • Adeno-associated virus vector gene expression occurs in nondividing cells in the absence of vector DNA integration.

    Terence R. Flotte;Sandra A. Afione;Pamela L. Zeitlin

  • Repeated aerosolized AAV-CFTR for treatment of cystic fibrosis: a randomized placebo-controlled phase 2B trial.

    Richard B Moss;Carlos Milla;John Colombo;Frank Accurso

  • Cl- channels in CF: lack of activation by protein kinase C and cAMP-dependent protein kinase

    Tzyh Chang Hwang;Luo Lu;Pamela L. Zeitlin;Dieter C. Gruenert

  • Evidence of CFTR Function in Cystic Fibrosis after Systemic Administration of 4-Phenylbutyrate

    Pamela L. Zeitlin;Marie Diener-West;Ronald C. Rubenstein;Michael P. Boyle

Frequent Co-Authors

William B. Guggino
William B. Guggino Johns Hopkins University
Garry R. Cutting
Garry R. Cutting Johns Hopkins University School of Medicine
Terence R. Flotte
Terence R. Flotte University of Massachusetts Chan Medical School
Bonnie W. Ramsey
Bonnie W. Ramsey University of Washington
Harvey B. Pollard
Harvey B. Pollard Uniformed Services University of the Health Sciences
Richard B. Moss
Richard B. Moss Stanford University
Barrie J. Carter
Barrie J. Carter National Institutes of Health
Marie Diener-West
Marie Diener-West Johns Hopkins University
David M. Jacobowitz
David M. Jacobowitz National Institutes of Health
John P. Clancy
John P. Clancy Cystic Fibrosis Foundation

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