Jon Clardy

Research.com Recognitions

• 2026 - Research.com Chemistry in United States Leader Award
• 2025 - Research.com Chemistry in United States Leader Award

Overview

Best Publications

• Molecular biological access to the chemistry of unknown soil microbes: a new frontier for natural products

  Jo Handelsman;Michelle R. Rondon;Sean F. Brady;Jon Clardy

  2800
  Citations

• Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature

  Paul G. Arnison;Mervyn J. Bibb;Gabriele Bierbaum;Albert Alexander Bowers

  2194
  Citations

• Cloning the soil metagenome: a strategy for accessing the genetic and functional diversity of uncultured microorganisms.

  Michelle R. Rondon;Paul R. August;Alan D. Bettermann;Sean F. Brady

  1736
  Citations

• Lessons from natural molecules

  Jon Clardy;Christopher Walsh

  1625
  Citations

• Atomic Structures of the Human Immunophilin FKBP-12 Complexes with FK506 and Rapamycin

  Gregory D. Van Duyne;Robert F. Standaert;P.Andrew Karplus;Stuart L. Schreiber

  1461
  Citations

• Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP.

  Jungwon Choi;Jie Chen;Stuart L. Schreiber;Jon Clardy

  1147
  Citations

• Target identification using drug affinity responsive target stability (DARTS)

  Brett Lomenick;Rui Hao;Nao Jonai;Randall M. Chin

  1119
  Citations

• GABA-modulating bacteria of the human gut microbiota

  Philip Strandwitz;Ki Hyun Kim;Darya Terekhova;Joanne K. Liu

  1101
  Citations

• D-amino acids trigger biofilm disassembly.

  Illana Kolodkin-Gal;Diego Romero;Shugeng Cao;Jon Clardy

  1055
  Citations

• Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

  Kazuo Tachibana;Paul J. Scheuer;Yasumasa Tsukitani;Hiroyuki Kikuchi

  1042
  Citations

• Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters.

  Peter Cimermancic;Marnix H. Medema;Jan Claesen;Kenji Kurita

  1042
  Citations

• ISOLATION AND STRUCTURE OF BRYOSTATIN 1

  George R. Pettit;Cherry L. Herald;Dennis L. Doubek;Delbert L. Herald

  947
  Citations

• Minimum Information about a Biosynthetic Gene cluster.

  Marnix H. Medema;Marnix H. Medema;Renzo Kottmann;Pelin Yilmaz;Matthew Cummings

  925
  Citations

• Diarrhetic shellfish toxins

  T. Yasumoto;M. Murata;Y. Oshima;M. Sano

  875
  Citations

• Ruminococcus gnavus , a member of the human gut microbiome associated with Crohn's disease, produces an inflammatory polysaccharide.

  Matthew T. Henke;Douglas J. Kenny;Chelsi D. Cassilly;Hera Vlamakis

  826
  Citations

• Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex

  GD Van Duyne;RF Standaert;PA Karplus;SL Schreiber

  805
  Citations

• New antibiotics from bacterial natural products.

  Jon Clardy;Michael A Fischbach;Christopher T Walsh

  789
  Citations

• A systematic analysis of biosynthetic gene clusters in the human microbiome reveals a common family of antibiotics

  Mohamed S. Donia;Peter Cimermancic;Christopher J. Schulze;Laura C. Wieland Brown

  735
  Citations

• Isolation and structure of brevetoxin B from the "red tide" dinoflagellate Ptychodiscus brevis (Gymnodinium breve)

  Yong-Yeng Lin;Martin Risk;Sammy M. Ray;Donna Van Engen

  718
  Citations

• Gene expression signature-based chemical genomic prediction identifies a novel class of HSP90 pathway modulators

  Haley Hieronymus;Justin Lamb;Kenneth N. Ross;Xiao P. Peng;Xiao P. Peng

  708
  Citations

• Isolation of antibiotics turbomycin a and B from a metagenomic library of soil microbial DNA.

  Doreen E. Gillespie;Sean F. Brady;Alan D. Bettermann;Nicholas P. Cianciotto

  689
  Citations